hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg16805/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1998  ( 1366 res)   mbg16805

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   RhoGEF domain                                   67.5    2.8e-16   1
C1_1     Phorbol esters/diacylglycerol binding domain    44.8    1.9e-09   1
PH       PH domain                                       44.0    3.5e-09   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
C1_1       1/1     694   744 ..     1    55 []    44.8  1.9e-09
RhoGEF     1/1     892  1082 ..     1   207 []    67.5  2.8e-16
PH         1/1    1126  1227 ..     1    92 []    44.0  3.5e-09

Alignments of top-scoring domains:
C1_1: domain 1 of 1, from 694 to 744: score 44.8, E = 1.9e-09
                   *->HhFvhrwnfkqptfCdhCgellwgslgkqGlkCswCklnvHkrChek
                      H+Fv++ +f +   C+ C++ l   lgk  l+C++Ck n Hk C   
   mKIAA1998   694    HQFVPG-TFSGVLQCSGCDKTL---LGKESLQCANCKANTHKGCKDA 736  

                   VppeCgcg<-*
                   Vpp+ +     
   mKIAA1998   737 VPPCTKKF    744  

RhoGEF: domain 1 of 1, from 892 to 1082: score 67.5, E = 2.8e-16
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                      v++El++TE   +++L i + v++k ++e+       l++ +++ iF
   mKIAA1998   892    VIFELMQTEVHHIQTLLIMSEVFRKGMKEEL-----QLDHSTVDKIF 933  

                   sNiediyefhreFLkssLearisssqfedlDekkiepsaqr.....lGdl
                   +++ +++e hr+F+  s+++r ++s            s+++   +++Gd+
   mKIAA1998   934 PCLDELLETHRHFFF-SMKERRQES---------CAGSDRNfvinqIGDI 973  

                   Flklkep.....flqvYgeYcsnkpyAqelleklrqaasnpqFaefldev
                   + + +++++ +++  +Yge+cs+++ A+ l +     ++n +F++f++ +
   mKIAA1998   974 LVQQFSEenaskMKRIYGEFCSHHKEAMSLFKE---LQQNKKFQNFIKIR 1020 

                   eassntgAkddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpd
                     + +        +++++  +l   qRi++Yp L+  +L +t+e    ++
   mKIAA1998  1021 NSNLLAR------RRGIPECILLVTQRITKYPVLVERILQYTKE--RTEE 1062 

                   redLkkaldllqdlaksiNe<-*
                   + dL kal+l++d++  ++    
   mKIAA1998  1063 HRDLCKALGLIKDMIAAVDL    1082 

PH: domain 1 of 1, from 1126 to 1227: score 44.0, E = 3.5e-09
                   *->vikeGwLlkkggkkswkkRyfvLfndvLlyykdkk........kkpk
                      + + G ++ k++ +++k+  + L +dvLl+ ++k+++      +++ 
   mKIAA1998  1126    LLHDGLVYWKTATGRFKDILALLLTDVLLFLQEKDqkyifaavDQKP 1172 

                   gsipLsgiqvekvpdnkrkncFeirt.dr..etlllqaeseeerkeWvka
                    +i+L+++  ++v +  ++ +F i+ ++ ++e ++++++s eer+ W++ 
   mKIAA1998  1173 SVISLQKLIAREVANE-ERGMFLISAsSAgpEMYEIHTNSKEERNNWMRR 1221 

                   iqsair<-*
                   iq+a++   
   mKIAA1998  1222 IQQAVE    1227 

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