hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/meh/meh01075/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1995  ( 1005 res)   meh01075

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Pkinase     Protein kinase domain                       230.6    2.3e-65   1
RCC1        Regulator of chromosome condensation (RCC    69.0    9.9e-17   4
Pkinase_Tyr Protein tyrosine kinase                      41.4    1.9e-14   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
Pkinase       1/1      73   329 ..     1   287 []   230.6  2.3e-65
Pkinase_Tyr   1/1      73   329 ..     1   272 []    41.4  1.9e-14
RCC1          1/4     408   462 ..     1    68 []    12.3     0.22
RCC1          2/4     465   516 ..     1    68 []    26.8   0.0005
RCC1          3/4     521   568 ..     1    68 []    23.7   0.0045
RCC1          4/4     636   686 ..     1    68 []    16.3     0.08

Alignments of top-scoring domains:
Pkinase: domain 1 of 1, from 73 to 329: score 230.6, E = 2.3e-65
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      y  +++lG+G+fG+  + ++  +  +V+ K++++ + ++k+++ a++
   mKIAA1995    73    YIPIRVLGRGAFGEATLYRRTEDDSLVVWKEVDLTRLSEKERRDALN 119  

                   rsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdylse
                     Ei il+ L+H+NI+ ++  f+d++ l + lEyc+gG     L+d +  
   mKIAA1995   120 --EIVILALLQHDNIIAYYNHFMDNTTLLIELEYCNGG----NLYDKIL- 162  

                   trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldengv
                    r+k +l f+e+ +  ++ Qi++++  +H+ gi+HRD+K  NI+l + + 
   mKIAA1995   163 -RQKDKL-FEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIFLTKANL 210  

                   vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD
                   +    K++D GlAkkl ++ +s + t+vGTp+Ym+PE+++ g +y  k+D
   mKIAA1995   211 I----KLGDYGLAKKL-NsEYSmAETLVGTPYYMSPELCQ-GVKYNFKSD 254  

                   vWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewds
                   +W++G++++ellt k  F+     ++l+  ++i++  +   e ds + + 
   mKIAA1995   255 IWAVGCVIFELLTLKRTFDAT---NpLNLCVKIVQGIR-AMEVDSSQYS- 299  

                   isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-*
                                 e+++L+  cL++DP++R+ a+ +l  P +   
   mKIAA1995   300 -------------LELIQLVHACLDQDPEQRPAADALLDLPLL    329  

Pkinase_Tyr: domain 1 of 1, from 73 to 329: score 41.4, E = 1.9e-14
                   *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtL.keigasseei
                       + +++LG+GaFGe   +tl+    +++  V  K ++     s++e 
   mKIAA1995    73    YIPIRVLGRGAFGE---ATLY-RRTEDDSLVVWKEVdLT-RLSEKE- 113  

                   eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd
                    r+d l+E+ i+  l +H+Ni+ ++   ++        l+i +Ey+ gG+
   mKIAA1995   114 -RRDALNEIVILALL-QHDNIIAYYNHFMD-NTT----LLIELEYCNGGN 156  

                   Lld.fLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL
                   L+d+ Lr++  ++ +  ++ + + +Qi ++ +  +  ++ HRD+ + N+ 
   mKIAA1995   157 LYDkILRQK--DKLFEEEMVVWYLFQIVSAVSCIHKAGILHRDIKTLNIF 204  

                   VsenlvVKIsDFGLaRdiynddyYvrkkgggklPvkWmAPEslkygkFts
                   +++ + +K +D GLa+ +   ++Y  + +        m+PE  +  k++ 
   mKIAA1995   205 LTKANLIKLGDYGLAKKL--NSEY-SMAETLVGTPYYMSPELCQGVKYNF 251  

                   kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLpr.PenCP
                   kSD+W+ G++++E++tl     +    +  ++ ++++  + ++ +    +
   mKIAA1995   252 KSDIWAVGCVIFELLTLK-RT-FDATNPLNLCVKIVQGIRAMEVdSSQYS 299  

                   delYdlMlqCWaedPedRPtFsel..verL<-*
                    el +l   C + dPe+RP   +l ++  L   
   mKIAA1995   300 LELIQLVHACLDQDPEQRPAADALldLPLL    329  

RCC1: domain 1 of 4, from 408 to 462: score 12.3, E = 0.22
                   *->dGrVYsl.....GcFRgenGqLGlgeeveeskGGRqGLERLlvPvlv
                      +  +Y++ + ++G      GqLG g  ++ +            P+ v
   mKIAA1995   408    EKELYTWvnmqgGT--KLHGQLGHGDKASYR-----------QPKHV 441  

                   mLKsrssslsekVvsvasGgqHtval<-*
                              +  +v++G+++tv++   
   mKIAA1995   442 -----EKLQGKAIHQVSCGDDFTVCV    462  

RCC1: domain 2 of 4, from 465 to 516: score 26.8, E = 0.0005
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                      +G++Y++G+  + +G  G +  v++ +        +l P ++     
   mKIAA1995   465    EGQLYAFGS--DYYGCMG-VDKVSGPE--------VLEPMQL----- 495  

                   ssslsekVvsvasGgqHtval<-*
                    + ls +V +v++G+ H v+l   
   mKIAA1995   496 NFFLSNPVEQVSCGDNHVVVL    516  

RCC1: domain 3 of 4, from 521 to 568: score 23.7, E = 0.0045
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                         VYs+Gc  ge+G+LGl+ e++              P+ v     
   mKIAA1995   521    --EVYSWGC--GEYGRLGLDSEEDYY-----------TPQRV----- 547  

                   ssslsekVvsvasGgqHtval<-*
                           v v +G + t++l   
   mKIAA1995   548 DVPKALIIVAVQCGCDGTFLL    568  

RCC1: domain 4 of 4, from 636 to 686: score 16.3, E = 0.08
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                       Gr++++Gc  +  GqLG +++ +++              ++    +
   mKIAA1995   636    RGRLLTFGC--NKCGQLG-VGNYKKR-----------LGINL---LG 665  

                   ssslsekVvsvasGgqHtval<-*
                   +  +   V  v++G+ +t a    
   mKIAA1995   666 GPLGGKQVIRVSCGDEFTIAA    686  

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