hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj04206/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1973  ( 1031 res)   mfj04206

Scores for sequence family classification (score includes all domains):
Model        Description                                Score    E-value  N 
--------     -----------                                -----    ------- ---
Lig_chan     Ligand-gated ion channel                   340.9    1.4e-98   1
SBP_bac_3    Bacterial extracellular solute-binding p   -21.6    8.1e-06   1
ANF_receptor Receptor family ligand binding region      -22.7      0.055   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
ANF_receptor   1/1      19   366 ..     1   423 []   -22.7    0.055
SBP_bac_3      1/1     459   806 ..     1   258 []   -21.6  8.1e-06
Lig_chan       1/1     570   848 ..     1   307 []   340.9  1.4e-98

Alignments of top-scoring domains:
ANF_receptor: domain 1 of 1, from 19 to 366: score -22.7, E = 0.055
                   *->qvlpAmelAieeiNadggillpgitlgyedddtcsksyalcsslsf.
                       +  A+++A+e +N+  g+l  +++l++++  + +          ++
   mKIAA1973    19    WPRDALLFAVENLNRVEGLLPYNLSLEVVMAIEAG----------Lg 55   

                   ................dp.aavaaaacllkskgVvaiiGPscss.vaiav
                   + +  + ++++++ ++dp    + +   +  +gV a++ +  s+++ + +
   mKIAA1973    56 dlplmpfsspsspwssDPfSFLQSVCHTVVVQGVSALLAFPQSQgEMMEL 105  

                   arlanefgiPlisy................gatspslsdksktryptffR
                     + + ++iP++s  +++ +++++++ + + +  +sls+           
   mKIAA1973   106 DLVSSVLHIPVLSIvrhefpresqnplhlqLSLENSLSS----------- 144  

                   tvpsdtkqgaAiadilkhtfgWkrvaviyddddydygeggcYFtlealee
                           +++ ++il +  +W+ ++++  ++d+ +        l   e+
   mKIAA1973   145 -------DADVTVSILTM-NNWYNFSLLLCQEDW-NITDF----LLLTEN 181  

                   alkeaggkvvavAqasdvvvvseviagdddftallkelkdlik.skarvv
                     k +   ++++         +   ++++d+ ++l++  + i++s++  v
   mKIAA1973   182 NSKFHLESIINI---------TANLSSTKDLLSFLQVQLENIRnSTPTMV 222  

                   vvcgssddlgllkrqilrqarelGlmsggyvwiltdlwstsldsqgdgsd
                   ++++    +    rqi++   + Gl   + +w+l d ++           
   mKIAA1973   223 MFGCDMGSI----RQIFEMSTQFGLSPPDLHWVLGDSQNVEE-------- 260  

                   lpwariagadeGlltartfppqldndkareaakgvlgftlkpspefqefl
                                         l ++++   + +    t+          
   mKIAA1973   261 ----------------------LRTEGLPLGLIAHGKTTQ---------- 278  

                   erlkkldtevnsyallaYDAVyllAhAlnetlsddpngtasgcnacrdsr
                             + + +++ DA+ l+A+A+  +  +      ++        
   mKIAA1973   279 ----------SVFEYYVQDAMELVARAVATA--TMIQPELAL-------- 308  

                   vddasnalg.gnlnlg.lkkw.dGsqlleylrnkvnFeGltGpvqfddng
                           +++n+ + + ++ + G+ l++ l n ++F Gl+G ++   + 
   mKIAA1973   309 ------LPStMNCMDVkTTNLtSGQYLSRFLAN-TTFRGLSGSIKVKGST 351  

                   grrpdyslvilnwdg<-*
                        +++ i+n ++   
   mKIAA1973   352 IVSSENNFFIWNLQY    366  

SBP_bac_3: domain 1 of 1, from 459 to 806: score -21.6, E = 8.1e-06
                   *->LrVGtegtypPFefkdeddsGklvGFDvDlakAiakklk........
                          ++++ +P  fk     +   G+ +Dl++ +a++++ + +    
   mKIAA1973   459    ----SSNDTVPIKFK-----KCCYGYCIDLLEQLAEDMNfdfdlyiv 496  

                   ......gvKvefvptdwdglipaLqsgkvDviiagmtiTpeRkkkvdFFS
                   ++++ ++    +++  w gl   L sg++ +++ +++i+ +R++++dF +
   mKIAA1973   497 gdgkygA----WKNGHWTGLVGDLLSGTANMAVTSFSINTARSQVIDF-T 541  

                   dPYytsgavlvtvkkdnelg..............................
                    P++ ++++++ v++ +  ++ +    + + +   +     + +    + 
   mKIAA1973   542 SPFFSTSLGIL-VRTRDTAApigafmwplhwtmwlgifvalhitaifltl 590  

                   ..................................................
                    + +++ + +++++++++  + ++  +       +++   ++++  +++ 
   mKIAA1973   591 yewkspfgmtpkgrnrnkvfsfssalnvcyallfgrtaaikppkcwtgrf 640  

                   ..............dlnsgaavsaiksleDLkGkkaKkvgvqlGttyed.
                     +          ++++ +         + + G    k+   l  ++ d+
   mKIAA1973   641 lmnlwaifcmfclsTYTANL-------AAVMVG---EKIYEELSGIH-Dp 679  

                   ..................gekllkkygakkgdkaevvtyddqpealqdLk
                   + ++++++ + ++ ++++ e+++++ +++ +  +    ++ +p+ +q Lk
   mKIAA1973   680 klhhpsqgfrfgtvressAEDYVRQSFPEMHEYMRRYNVPATPDGVQYLK 729  

                   nG..RiDAvlnDrlvllyyaayllkkpdgakplkivgdplsdpkefgegy
                   n ++++DA+++D++ l y    +    d   +l +vg+p+       egy
   mKIAA1973   730 NDpeKLDAFIMDKALLDY---EVSIDADC--KLLTVGKPFAI-----EGY 769  

                   giavrKgkddkeLkdklNkALkelkadGtlkkIseKwFgt<-*
                   gi++     +  L+  + + +   k  G ++ + +Kw++    
   mKIAA1973   770 GIGLPP---NSPLTSNISELISQYKSHGFMDVLHDKWYKV    806  

Lig_chan: domain 1 of 1, from 570 to 848: score 340.9, E = 1.4e-98
                   *->slevWlcilaayllvsvvlwlverwfsPyewrgnrqprpcaeddeaP
                      ++++Wl+i ++ l+++++++++++w sP+++++++++r+        
   mKIAA1973   570    HWTMWLGI-FVALHITAIFLTLYEWKSPFGMTPKGRNRN-------- 607  

                   qspeeepnqftlsnslWFsfgalmq.QGcdelPrslSgRivvgvWwfFaL
                            f++s++l+ +++ l+ + ++ + P++++gR+++++W++F++
   mKIAA1973   608 -------KVFSFSSALNVCYALLFGrTAAIKPPKCWTGRFLMNLWAIFCM 650  

                   ilisSYTANLAAFLTvermqspIesleDLakqnpkieYGtlrggstftff
                   +++s+YTANLAA+++ e+++++ ++++D+++++   +  ++r+g++++++
   mKIAA1973   651 FCLSTYTANLAAVMVGEKIYEELSGIHDPKLHH-PSQ--GFRFGTVRESS 697  

                   keskiptyrrmweymnsrkgrskaPsvfvksyeeGvqrVrkgpenglyAf
                   +e +   +r+ +++m+ +++r     ++v ++ +Gvq +++ p ++l+Af
   mKIAA1973   698 AEDY---VRQSFPEMHEYMRR-----YNVPATPDGVQYLKNDP-EKLDAF 738  

                   lmEstyleyevarnpdCdLttvGevlfgtkGYGIAlpkgSPlrdklslAI
                   +m+ + l+yev+ + dC+L tvG  +f+ +GYGI+lp +SPl++++s  I
   mKIAA1973   739 IMDKALLDYEVSIDADCKLLTVGK-PFAIEGYGIGLPPNSPLTSNISELI 787  

                   LeLsEsGelekLenKWwkkkgkCpsesta.vsssqLglenfaGlFliLgi
                    +++  G+++ L++KW+k    C + s+a +++ q+g+++f GlF++L+i
   mKIAA1973   788 SQYKSHGFMDVLHDKWYKVV-PCGKRSFAvTETLQMGIKHFSGLFVLLCI 836  

                   GlvlallvalfE<-*
                   G++l++l+ ++E   
   mKIAA1973   837 GFGLSILTTIGE    848  

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