hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbp/mbp00252/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1965  ( 690 res)   mbp00252

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
VWD      von Willebrand factor type D domain            147.7    2.1e-40   1
VWC      von Willebrand factor type C domain            135.7    8.3e-37   5
TIL      Trypsin Inhibitor like cysteine rich domain     33.3    5.6e-06   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
VWC        1/5      55   110 ..     1    84 []    13.8    0.056
VWC        2/5     113   168 ..     1    84 []    14.0    0.054
VWC        3/5     171   229 ..     1    84 []    55.4  1.2e-12
VWC        4/5     243   294 ..     1    84 []    34.8  1.9e-06
VWC        5/5     306   362 ..     1    84 []    50.6  3.5e-11
VWD        1/1     369   519 ..     1   167 []   147.7  2.1e-40
TIL        1/1     634   687 ..     1    68 []    33.3  5.6e-06

Alignments of top-scoring domains:
VWC: domain 1 of 5, from 55 to 110: score 13.8, E = 0.056
                   *->CvqnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvlC
                      C   G v +    +  d  P     C+ +C+C++         +v C
   mKIAA1965    55    CENEGEVLQI--PFITD-NP-----CI-MCVCLN--------KEVTC 84   

                   dkitCppelLpsldCpnprrvdalvippGECCpewvC<-*
                   ++ +Cp     s dC+ +      ++  G CC+  +C   
   mKIAA1965    85 KREKCPV---LSRDCALA------IKQRGACCE--RC    110  

VWC: domain 2 of 5, from 113 to 168: score 14.0, E = 0.054
                   *->CvqnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvlC
                      C + G+ Y+++  W+    P     C     C+         g+v  
   mKIAA1965   113    CTHEGRTYNSSFKWQTPAEP-----CV-LRQCQE--------GVVTE 145  

                   dkitCppelLpsldCpnprrvdalvippGECCpewvC<-*
                   + ++C  +      C+ p      +++ G CCp  +C   
   mKIAA1965   146 SEVRC--V----VHCKKP------AEHQGACCP--TC    168  

VWC: domain 3 of 5, from 171 to 229: score 55.4, E = 1.2e-12
                   *->CvqnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvlC
                      Cv+ Gv+Y++ge+++p+       kC+ +C+C          g+++C
   mKIAA1965   171    CVFEGVQYREGEEFQPEG-----NKCI-TCSCVG--------GRTQC 203  

                   dkitCppelLpsldCpnprrvdalvippGECCpewvC<-*
                    + +Cp      l+Cp+ +       p G+CCp   C   
   mKIAA1965   204 VREVCPI-----LSCPQHL----SHTPSGQCCP--KC    229  

VWC: domain 4 of 5, from 243 to 294: score 34.8, E = 1.9e-06
                   *->CvqnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvlC
                      C++++ vY ng +++ d        Ct +CtC+d        +  +C
   mKIAA1965   243    CLFRSDVYDNGASFVYDN-------CT-VCTCKD--------STMVC 273  

                   dkitCppelLpsldCpnprrvdalvippGECCpewvC<-*
                   +k+ C+     +  C +          ++ CC+   C   
   mKIAA1965   274 KKK-CSH----PGVCNSD---------EDACCE--DC    294  

VWC: domain 5 of 5, from 306 to 362: score 50.6, E = 3.5e-11
                   *->CvqnGvvYengetWkpdsqPnGvdkCtyiCtCddiedavrlggkvlC
                      C+++++++++ge W +         C  iC C +        gk++C
   mKIAA1965   306    CKFGSKIFRDGEMWSSVN-------CS-ICACVK--------GKTEC 336  

                   dkitCppelLpsldCpnprrvdalvippGECCpewvC<-*
                   +k+ C p+    ++Cp++     ++ + + CCp  +C   
   mKIAA1965   337 RKKQCVPV----SSCPQG-----KILNRKGCCP--IC    362  

VWD: domain 1 of 1, from 369 to 519: score 147.7, E = 2.1e-40
                   *->CsvsGdphytTFDGrtYtfpgnCsYvlvlaqdcssesdffsfsvlnk
                      C+v+Gdphy+TFDGrt++f+g+C+Yv  l++dcss      f vl k
   mKIAA1965   369    CTVFGDPHYNTFDGRTFNFQGTCQYV--LTKDCSSPA--SPFQVLVK 411  

                   nvrcgse.vtclksvkvilgnveielkdgnadkdqvkVlvNgqkvslslP
                   n+   + + +++ksv ++lg+++++l+        ++V  Ng ++ l  P
   mKIAA1965   412 NDARRTRsFSWTKSVELMLGESTVSLQQH------LTVRWNGSRIAL--P 453  

                   yssdngnlieilgsgfvvvllprlgvtlqfdwdgrtrlfvslspsyrgkt
                    + + + +i+  g   + v++ r g+++++d+d+  ++ v++ p ++gk+
   mKIAA1965   454 CHTPHF-HIDLDGYL-LKVTT-RAGLEISWDGDS--FVEVMAAPHLKGKL 498  

                   cGLCGnfngepadDfrtpdGs<-*
                   cGLCGn+ng ++dD+   dG    
   mKIAA1965   499 CGLCGNYNGHKRDDLIGGDGN    519  

TIL: domain 1 of 1, from 634 to 687: score 33.3, E = 5.6e-06
                   *->CPaneqyteCgpsCepsCsnpdgplettppCegtSpkvPstCkegvC
                      C    +y +Cgp C  +C+n ++      pC        ++C+ g C
   mKIAA1965   634    CKHGAVYDTCGPGCVKTCDNWNE----IGPCN-------KPCIAG-C 668  

                   vCqpGyVrnndgdkCVprseC<-*
                    C+   V+++   +C+++  C   
   mKIAA1965   669 HCPANLVLHKG--RCIKPVLC    687  

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