hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpg/mpg00887/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1851  ( 705 res)   mpg00887

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
LRR_1    Leucine Rich Repeat                             59.3    8.5e-14   6
Hexapep  Bacterial transferase hexapeptide (three rep    32.5    9.4e-06   3
LRRNT    Leucine rich repeat N-terminal domain           22.3      0.011   1
ig       Immunoglobulin domain                           21.0      0.027   1
V-set    Immunoglobulin V-set domain                      3.9       0.25   1
I-set    Immunoglobulin I-set domain                    -16.4       0.26   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
Hexapep    1/3      88   105 ..     1    18 []    19.8    0.065
Hexapep    2/3     106   123 ..     1    18 []     7.0  1.3e+02
Hexapep    3/3     134   151 ..     1    18 []     6.2  1.7e+02
LRRNT      1/1     230   257 ..     1    34 []    22.3    0.011
LRR_1      1/6     259   282 ..     1    25 []    11.5       20
LRR_1      2/6     283   306 ..     1    25 []    10.8       33
LRR_1      3/6     307   330 ..     1    25 []    15.0      1.8
LRR_1      4/6     331   354 ..     1    25 []    10.5       36
LRR_1      5/6     355   378 ..     1    25 []    11.9       16
LRR_1      6/6     381   404 ..     1    25 []    12.7      8.8
ig         1/1     490   551 ..     1    65 []    21.0    0.027
I-set      1/1     476   569 ..     1    97 []   -16.4     0.26
V-set      1/1     475   569 ..     1   130 []     3.9     0.25

Alignments of top-scoring domains:
Hexapep: domain 1 of 3, from 88 to 105: score 19.8, E = 0.065
                   *->gviIGdnvvIgpgvvIgd<-*
                       ++IG n+ Igp+v +g+   
   mKIAA1851    88    SARIGQNCSIGPNVSLGP    105  

Hexapep: domain 2 of 3, from 106 to 123: score 7.0, E = 1.3e+02
                   *->gviIGdnvvIgpgvvIgd<-*
                      gv+++d+v I   +v+ d   
   mKIAA1851   106    GVVVEDGVCIRRCTVLRD    123  

Hexapep: domain 3 of 3, from 134 to 151: score 6.2, E = 1.7e+02
                   *->gviIGdnvvIgpgvvIgd<-*
                       +i+G ++ +g+ v+  +   
   mKIAA1851   134    SCIVGWRCRVGQWVRMEN    151  

LRRNT: domain 1 of 1, from 230 to 257: score 22.3, E = 0.011
                   *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-*
                       Cp +C C      + v  C grgL+  +P+ lP   
   mKIAA1851   230    NCPDICICA-----ADVLSCAGRGLQ-DLPVALP    257  

LRR_1: domain 1 of 6, from 259 to 282: score 11.5, E = 20
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +  eLdLs+ N  l + l+p+ l  l+   
   mKIAA1851   259    TAAELDLSH-N-AL-KRLHPGwLaPLS    282  

LRR_1: domain 2 of 6, from 283 to 306: score 10.8, E = 33
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L+ L+L++ N +l+  l  +++ + +   
   mKIAA1851   283    RLRALHLGY-N-KLE-VLGHGaFtNAS    306  

LRR_1: domain 3 of 6, from 307 to 330: score 15.0, E = 1.8
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                       L++LdLs+ N +l + l+ ++l+gl    
   mKIAA1851   307    GLRTLDLSS-N-ML-RMLHTHdLdGLE    330  

LRR_1: domain 4 of 6, from 331 to 354: score 10.5, E = 36
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +Le+L L + N sl  +l  ++++gl+   
   mKIAA1851   331    ELEKLLLFN-N-SLM-HLDLDaFqGLR    354  

LRR_1: domain 5 of 6, from 355 to 378: score 11.9, E = 16
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                       L +L+Ls+ N +ls s++ ++l+gl    
   mKIAA1851   355    MLSHLYLSC-N-ELS-SFSFNhLhGLG    378  

LRR_1: domain 6 of 6, from 381 to 404: score 12.7, E = 8.8
                   *->nLeeLdLsgCNpslsgs..lppsl.glp<-*
                      +L++LdLs+ N  l ++ ++p+ l  lp   
   mKIAA1851   381    RLRTLDLSS-N-WL-KHisIPE-LaALP    404  

ig: domain 1 of 1, from 490 to 551: score 21.0, E = 0.027
                   *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq
                      G+s++L C +   + p ++v W + + +l     +      +  + +
   mKIAA1851   490    GQSLRLFCNT---SVPATRVAWVSPKNeLLvAPASQDGSIAVLADGS 533  

                   tsLtitnvtpeDggtYtCvv<-*
                     L i +v+++++g++ C +   
   mKIAA1851   534 --LAIGRVQEQHAGVFVCLA    551  

I-set: domain 1 of 1, from 476 to 569: score -16.4, E = 0.26
                   *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKd.Gqplssvl.
                      P  + + + + +q+G+s+r+ C+ +  P   V W   +++ l +   
   mKIAA1851   476    PGLELPEEQLHAQVGQSLRLFCNTS-VPATRVAWVSPkNELLVA-Pa 520  

                   lpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNs..aGeaeasae
                     ++ + v +dg     +L I +vq   +G+ +C A+ ++    ++ + +
   mKIAA1851   521 SQDGSIAVLADG-----SLAIGRVQEQHAGVFVCLASGPrlHHNQTLEYN 565  

                   LtVq<-*
                   + Vq   
   mKIAA1851   566 VSVQ    569  

V-set: domain 1 of 1, from 475 to 569: score 3.9, E = 0.25
                   *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss
                      +  ++  p++           +++++G+s++L C  s          
   mKIAA1851   475    APGLEL-PEE----------QLHAQVGQSLRLFCNTS-----V---- 501  

                   gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn
                     ++v W+      +   l++                + + +g++ + ++
   mKIAA1851   502 PATRVAWVS----PKNELLVA----------------PASQDGSIAVLAD 531  

                   pskgdfsLtIsnlqlsDsGtYyCa..........gggtrLtVl<-*
                   +s     L I ++q  + G+  C  ++++ +++   ++++ V    
   mKIAA1851   532 GS-----LAIGRVQEQHAGVFVCLasgprlhhnqTLEYNVSVQ    569  

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