hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/TIGRFAMs_HMM.LIB Sequence file: /cdna4/rodent/full/goal/mfk/mfk00190/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1846 ( 683 res) mfk00190 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Ac_CoA_lig_AcsA Ac_CoA_lig_AcsA: acetate--CoA ligase 1463.5 0 1 propion_prpE propion_prpE: propionate--CoA ligase 465.4 4.8e-136 1 AA-adenyl-dom AA-adenyl-dom: amino acid adenylation 8.1 3.8e-12 1 menE menE: O-succinylbenzoate-CoA ligase -83.1 1.1e-08 1 ac_ac_CoA_syn ac_ac_CoA_syn: acetoacetyl-CoA syntha -83.5 2.3e-14 1 benz_CoA_lig benz_CoA_lig: benzoate-CoA ligase fam -157.6 7e-11 1 4_coum_CoA_lig 4_coum_CoA_lig: 4-coumarate--CoA liga -197.5 0.22 1 DHB_AMP_lig DHB_AMP_lig: 2,3-dihydroxybenzoate-AM -263.6 4.8e-11 1 D-ala-DACP-lig D-ala-DACP-lig: D-alanine-activating -299.2 2.2e-06 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- AA-adenyl-dom 1/1 136 574 .. 1 452 [] 8.1 3.8e-12 4_coum_CoA_lig 1/1 201 638 .. 1 416 [] -197.5 0.22 menE 1/1 136 642 .. 1 490 [] -83.1 1.1e-08 DHB_AMP_lig 1/1 79 643 .. 1 534 [] -263.6 4.8e-11 benz_CoA_lig 1/1 100 645 .. 1 520 [] -157.6 7e-11 D-ala-DACP-lig 1/1 106 648 .. 1 513 [] -299.2 2.2e-06 Ac_CoA_lig_AcsA 1/1 46 671 .. 1 643 [] 1463.5 0 propion_prpE 1/1 46 674 .. 1 634 [] 465.4 4.8e-136 ac_ac_CoA_syn 1/1 20 680 .. 1 676 [] -83.5 2.3e-14 Alignments of top-scoring domains: AA-adenyl-dom: domain 1 of 1, from 136 to 574: score 8.1, E = 3.8e-12 *->TYrELderAnrLArhLraagGGvgpgdrVavlleRSaelvvAiLAvL TYrEL e + rLA+ L+ ++G v +gdrVa++++ S+ +v+A+LA+ mKIAA1846 136 TYRELLETTCRLANTLK-RHG-VHRGDRVAIYMPVSPLAVAAMLACA 180 KAGaAYVPlDPayPaeRlafiledagarllLtdsalaerlaglvl.e.ev + Ga + + ++ ae la + da++++++t + + g v + + + mKIAA1846 181 RIGAIHTVVFAGFSAESLAGRINDAKCKAVITFNQ--GLRGGRVVeLkKI 228 illdplelaaladapappppaartd...................slppll ++ + + +++ + +++++ ++ ++ + + +++ ++ + +p ++ mKIAA1846 229 VDEA-VKSCPTVQHVLVAHRTDTKVpmgsldipleqemakeapvCTPESM 277 sgpddlvAYvIYTSGSTGrPKGVvvtHrslvnllawlarlrygldrgngp s+ d l +YTSGSTG+PKG v t+++ + ++a + l ++ p mKIAA1846 278 SSEDML--FMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDY----QP 321 ddrvLqfaslsFDaSvee.ifgaLlaGAtlvvppedeerlddaallaali +d++ ++a +++ + + g+L++GAt+v+ +++ +d+++ ++++ mKIAA1846 322 GDVFGCVADIGWITGHSYvVYGPLCNGATTVLFESTPVYPDAGRYWETVQ 371 aegpvTvlsltPsllalLaeeavpsleeaeerlaalssLrlvilgGEalt + ++ + P+ +lL+ + + + + + +ssLr++ ++GE+++ mKIAA1846 372 RLK-INQFYGAPTAVRLLLKYGDA----WVKKYD-RSSLRTLGSVGEPIN 415 palvdrfwrargggrpdarliNlYGPTEtTvwsta.trvdpddargepep +++ + ++ ++g +++ l+ ++ TEt + a+ + +++++ ++ mKIAA1846 416 HEAWEW-LHKVVG-DGRCTLVDTWWQTETGGICIApRPSEDGAEILPGM- 462 gpvPIGrPlantrlyVLDddDhlrpvPvGvvGELyI..gGpGVArGYlnr rP+ + + D+ ++ + v G L+I+++ pG Ar mKIAA1846 463 ----AMRPFFGIVPVLMDEK-GNVLEGGDVSGALCIsqAWPGMAR----T 503 PeLTAerFvpdPfaggdgarlgrnetRlYRTGDLvRwlpDGnLeFlGRiD +rFv+ f++ +g Y TGD + +++ G + GR+D mKIAA1846 504 IYGDHQRFVDAYFRAYPG---------YYFTGDGAHRTEGGYYQITGRMD 544 dQVKIRGyRIELgEIEaaLlrhpgVreAvV<-* d + I G+R +EIE a + hp+V e +V mKIAA1846 545 DVINISGHRLGTAEIEDAMADHPAVPETAV 574 4_coum_CoA_lig: domain 1 of 1, from 201 to 638: score -197.5, E = 0.22 *->qaLdaeaVrRLlvSLIaAElrDLLReGRvq..rgdlpeArlLtAGHP + da + I + LR GRv + + + eA + mKIAA1846 201 RINDAK-----CKAVITFNQG--LRGGRVVelKKIVDEAVKSCP--- 237 SPDDlriDeetLglDSLarLdLvsavadFFdLsetgvE......Dyllve v ++t + + ++ D l + mKIAA1846 238 ------------------------TVQHVLVAHRTDTKvpmgslDIPLEQ 263 RtLqGWiDRigemvdLiadrstLmGetArltFaTSGSTgtPkPvtHSwAa + + s + e + TSGSTgtPk H A mKIAA1846 264 E--------MAKEAPVCTPES-MSSEDMLFMLYTSGSTGTPKGLVHTQAG 304 LlrEAeAlAkalglrpapvrrVialvP.aHHLYGflFsvlLPellGae.. l A A+ l p+ V ++v + + G + v P Ga++ mKIAA1846 305 YLLYA-AMTHKLVFDYQPG-DVFGCVAdIGWITGHSYVVYGPLCNGATtv 352 vkelaaapaaa......llR........eArpgDLivatPflWeyLad.a + e++ + a++ +++ R + ++ + + L W d++ mKIAA1846 353 LFESTPVYPDAgrywetVQRlkinqfygAPTAVRLLLKYGDAWVKKYDrS 402 dyrlPGDvvGVsSgApleaalwrsllaa...GLeaLleVYGAtEtGGIGL r G s g p+ + w l ++G L + tEtGGI mKIAA1846 403 SLRTLG-----SVGEPINHEAWEWLHKVvgdGRCTLVDTWWQTETGGICI 447 Rrapddd.............FrlLPdLarsa......dalssAL....nP +p++d+ + ++ ++ F P L ++ ++ + s AL ++ mKIAA1846 448 APRPSEDgaeilpgmamrpfFGIVPVLMDEKgnvlegGDVSGALcisqAW 497 DGlArrl..dLq.................DrLrWdddrrFvieGRlDeiL G Ar++ +d q+ + + ++ ++D ++ + + i+GR+D+++ mKIAA1846 498 PGMARTIygDHQrfvdayfraypgyyftgDGAHRTEGGYYQITGRMDDVI 547 QVgGvNVspghVkdvLeaepaVealAvR.....ldGeGsRRRLKAfivvA + G + + d +paV Av + +++ Ge Afiv mKIAA1846 548 NISGHRLGTAEIEDAMADHPAVPETAVIgyphdIKGE----AAFAFIVLK 593 ReDAdeeeLeieLraraaeHLpApaRPdrfrfgteLPrtaaGKlr<-* de + eL+ +a a Pd+ + LP+t+ GK mKIAA1846 594 DNISDENMVVNELKLSVATKIAKYAVPDQILVVKRLPKTRSGKVM 638 menE: domain 1 of 1, from 136 to 642: score -83.1, E = 1.1e-08 *->tfaeLdkeaarlAkaleaqsvRsgdrVALlgqNsvemvlllhAclll t+ eL ++ rlA l+ ++v +gdrVA++ + s+ v + +Ac ++ mKIAA1846 136 TYRELLETTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARI 182 GveialLNtrPLARLtenerttqledlkvellltdsl.........lesE G+ + +++ +++ + d k ++t + ++++ +l+ mKIAA1846 183 GAIHTVVFAG----FSAESLAGRINDAKCKAVITFNQglrggrvveLK-- 226 KkkvEedfqa.......isldeleaeaeDittnsLLDntmG...iaeets k v+e++ + ++ ++ + ++++ + mG+ +i+ e + mKIAA1846 227 -KIVDEAVKScptvqhvLVAHRTDTKVP-----------MGsldIPLEQE 264 vetvvPKEsPseklsa..dFsmdqiAtlmfTSGsTGkPKAVvhT.frnHy + KE+P + +++++s ++ +TSGsTG+PK+ vhT+ + + mKIAA1846 265 ----MAKEAP---VCTpeSMSSEDMLFMLYTSGSTGTPKGLVHTqAGYLL 307 eSAvGsaenLgftesDnWLlsLPLyHvSGlS.iLfRwLleGaTlkv.... A+ ++ + ++D + + + G S +++ L +GaT ++ +++ mKIAA1846 308 YAAMTHKLVFDYQPGDVFGCVADIGWITGHSyVVYGPLCNGATTVLfest 357 .vdkfaaeqllesIanekVTHiSLVPTqLkRlLdesgsneepe...sLrk +v ++a e + k++ PT lL+ + + ++++sLr mKIAA1846 358 pVYPDA-GRYWETVQRLKINQFYGAPTAVRLLLKYGDAWVKKYdrsSLRT 406 iLLG..GsaiPap....LieeAqekGlPiYlsYGMTEtaSQvvTlep... LG+ G++i + + L + + ++ + TEt ++ +p+++ mKIAA1846 407 --LGsvGEPINHEawewLHKVVGDGRCTLVDTWWQTETGGICIAPRPsed 454 ..evlkakldsvGrpLag.rEikIkvddqvCEkegh.GEImv..KGanLm + e+l++ + rp +g + + + v E ++G + ++++ ++ + mKIAA1846 455 gaEILPG---MAMRPFFGiVPVLMDEKGNVLEGGDVsGALCIsqAWPGMA 501 kgYlqqngelqeafeqn..GWfkTGDlGeldgdGfLyvlgRrddli.ISG ++ + a + +G+ TGD + G+ + gR dd i+ISG mKIAA1846 502 RTIYGDHQRFVDAYFRAypGYYFTGDGAHRTEGGYYQITGRMDDVInISG 551 GENIy...PeEIEkvlyshPgvqeAvVvpkpDaewGqvPvAyivsesGDd ++ + +EIE++ hP+v e +V++ p + G A+iv+ mKIAA1846 552 ----HrlgTAEIEDAMADHPAVPETAVIGYPHDIKGEAAFAFIVLKD--- 594 eisqa.....kLtayLkekLaKyKlPiaftlldelpynasGsiKilRnqL is+++ ++L + k+aKy +P + ++ +lp++ sG K+ R L mKIAA1846 595 NISDEnmvvnELKLSVATKIAKYAVPDQILVVKRLPKTRSG--KVMRRLL 642 <-* mKIAA1846 - - DHB_AMP_lig: domain 1 of 1, from 79 to 643: score -263.6, E = 4.8e-11 *->ieF.TpWPeeLAerYRekGYWqDkpL...tDiLekqAarrPdaiAii ++ +T W + + G ++ L+ + L ++ ++ P+ iA+i mKIAA1846 79 TPYhTVWDCDFRTG--KIGWFLGGQLnvsVNCLDQHVQKSPETIALI 123 ......cGnrqfsYreLdqradnLAagLtklGIkkGDtavVQLP....Ni ++++++ + + +YreL++ +LA L + G+ +GD++ + P ++ + mKIAA1846 124 werdepGTEVRITYRELLETTCRLANTLKRHGVHRGDRVAIYMPvsplAV 173 AEFYivFFALLklGvaP..VlALFSHrksE.LraYAqqiepalliidra. A A + G+ + V+A FS +E+L + ++ i ++ mKIAA1846 174 A----AMLACARIGAIHtvVFAGFS---AEsLAGRINDAKCKAVITFNQg 216 ...hslFdydafarqLkaklPtLrnvivaGrkir...vedelflwLespa ++ + + ++ +Pt + v+va ++++ + +l+++Le mKIAA1846 217 lrgGRVVELKKIVDEAVKSCPTVQHVLVAH-RTDtkvPMGSLDIPLEQEM 265 eePAvkfeAptksdeVAFFQL.SGGSTGTPKLIPRTHnDY.yYSVrrSVE ++ A ++ ++ s+e F L GSTGTPK T Y Y mKIAA1846 266 AKEAPVCTPESMSSEDMLFMLyTSGSTGTPKGLVHTQAGYlLYAAMTHKL 315 ICeLtqqTRYLCALP....aAHNYPLSSPGaLGVFyAGGcVVLAad.... + + ++ C+ + + H Y + G + G + VL +++ mKIAA1846 316 VFDYQPGDVFGCVADigwiTGHSYV-----VYGPLCNGATTVLFEStpvy 360 PsPtdcFpLIErHkVtvTALVPPavaLWl...qaaeEGksradLsSLkLl P + r k++ P av L l+ ++a ++d sSL+ l mKIAA1846 361 PDAGRYWETVQRLKINQFYGAPTAVRLLLkygDAWV---KKYDRSSLRTL 407 QVGGAkfSealARrvPkvlG...CkLQQVFGMAE.GLVNYT.RL.DDsdE G ++ + kv G+++C+L E+G + +R + D +E mKIAA1846 408 GSVGEPINHEAWEWLHKVVGdgrCTLVDTWWQTEtGGICIApRPsEDGAE 457 iIftTQGrPmSpdDEvrVvDdeGnpvapGee.GmL........lTRGPYT i rP + v+ D+ Gn + G ++G L ++ +++ R T mKIAA1846 458 ILPGMAMRPFFGIVPVL-MDEKGNVLEGGDVsGALcisqawpgMAR---T 503 fRG........YYkapeHNAkaFdaeGFYyTGDlVkltpEGYivVvGRaK + G++++ + Y +a G Y TGD + +t GY ++GR mKIAA1846 504 IYGdhqrfvdaYFRA---------YPGYYFTGDGAHRTEGGYYQITGRMD 544 DQINRGGEKiAAEEiENlLLkHPaVidAALVSMpDelLGEkSCAFIVvk. D IN G EiE + HPaV A + p GE AFIV+k+ mKIAA1846 545 DVINISGHRLGTAEIEDAMADHPAVPETAVIGYPHDIKGEAAFAFIVLKd 594 ...dpdSlkavqLrrFLreaGlAeYKLPDRvefidslPlTaVGKiDKkaL + +d++ +L+ +A Y PD++ + lP+T GK+ +L mKIAA1846 595 nisDEN-MVVNELKLSVATK-IAKYAVPDQILVVKRLPKTRSGKVMRRLL 642 R<-* R mKIAA1846 643 R 643 benz_CoA_lig: domain 1 of 1, from 100 to 645: score -157.6, E = 7e-11 *->ekYNAAedLldRNvveGRGgKtAFi......DdvsSLsYgELeaevr ++ N + ld v + +A i +++++ + + +Y EL + mKIAA1846 100 GQLNVSVNCLDQHVQKS-PETIALIwerdepGTEVRITYRELLETTC 145 RvaaaLRtrLGVkrEeRVllvmLDgvDFPi......vFLGAIrAGIVPVa R+a+ L r GV r +RV++ m P+++ + L r G + mKIAA1846 146 RLANTLK-RHGVHRGDRVAIYM------PVsplavaAMLACARIGAIHTV 188 lNTLLTADdYaYmLeDSRARVvfVSe.........eLlPVikealgklPh + A a D ++v+ ++ ++++ eL + ea+ P+ mKIAA1846 189 VFAGFSAESLAGRINDAKCKAVITFNqglrggrvvELKKIVDEAVKSCPT 238 LehvVvvGakAApLEaGekq..LAelLAteseqfkpAATraDDpAFWLYS hv v+ + + G ++ +L ++A e + +p D F LY mKIAA1846 239 VQHVLVAHRTDTKVPMGSLDipLEQEMAKEAPVCTPESMSSEDMLFMLYT 288 SGSTGmPKGVvHvHSnlrvTAElYARrvLGiREdDVvFSAAKLFFAYGLG SGSTG PKG vH+ + A v + +DV A G mKIAA1846 289 SGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYQPGDVFGCVADIGWITGHS 338 NALtFPMsVGATaVLm...aERPTPdaVFdrlrrGVGGhqPtiFYGVPTL P+ GAT+VL ++++ P + + ++ r + FYG+PT mKIAA1846 339 YVVYGPLCNGATTVLFestPVYPDAGRYWETVQR----LKINQFYGAPTA 384 YAaML..AdPdlpaEdlekrLRlCtSAGEALPeeVGrrWqaRFG...vDI L+ d ++ d +LR S GE+ e G+++ mKIAA1846 385 VRLLLkyGDAWVKKYD-RSSLRTLGSVGEPINHEAWEWLHKVVGdgrCTL 433 lDGvGSTEMLHIFLSNlP....gdVkYGTSGkPVPGYrlRLvgEDgGqdV +D TE + I +P++++ + G P G L + + G mKIAA1846 434 VDTWWQTETGGICIAPRPsedgAEILPGMAMRPFFGIVPVLMD-EKGNVL 482 AdGEv.GELlvs...GPSSAagYWNnReKsRaTFeG..eWTRsGDKYvRn G v+G L +s+ + + + Y a F ++ +GD +R mKIAA1846 483 EGGDVsGALCISqawPGMARTIYGDHQRFVDAYFRAypGYYFTGDGAHRT 532 ddGvYTYaGRtDDmlKVSGIyVSPFEvEsALiaHpaVLEAAVVgveDedG G+Y GR DD +SG E+E A HpaV E AV+g + mKIAA1846 533 EGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGYP---H 579 LiKPK...AFvVLrpGadidneaLeteLKeHVKdklaPyKYPRWIefVDd iK AF+VL+ d eLK V k+a y P I +V mKIAA1846 580 DIKGEaafAFIVLKDNI-SDENMVVNELKLSVATKIAKYAVPDQILVVKR 628 LPKTATGKIQRFKLREg<-* LPKT +GK+ R +LR mKIAA1846 629 LPKTRSGKVMRRLLRKI 645 D-ala-DACP-lig: domain 1 of 1, from 106 to 648: score -299.2, E = 2.2e-06 *->klIeaIdafAekePdliay....ryeGqe..lTYqqLkeqSDrlAaf + +d + +k P +ia+ ++++ G+e + TY++L e rlA mKIAA1846 106 --VNCLDQHVQKSPETIALiwerDEPGTEvrITYRELLETTCRLANT 150 iqerllpeKeKPIiVfGhmepeMlvaFLGsiKsGHAYIPVDtsiPlERIe + + + + ++ +p+ ++a+L+ G V + E + mKIAA1846 151 LKRHGVHRGD-RVAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLA 199 qIkeaAkPelvIe...............taeLsidl............ve ++ Ak +vI+ +++ ++++ + ++++++ + ++ ++ ++++ mKIAA1846 200 GRINDAKCKAVITfnqglrggrvvelkkIVDEAVKScptvqhvlvahrTD 249 tetdvitlea.ledaltsgaGpavdfdhaVkgdDnyYIIyTSGtTGkPKG t+ ++ +l+ +le+ ++ a +v + D yTSG+TG PKG mKIAA1846 250 TKVPMGSLDIpLEQEMAKEA--PVCTPESMSSEDMLFMLYTSGSTGTPKG 297 VQIShdNLvSFTNWmleDKEFklsegkqfLnQAPySFDLSVMdL...... ++ + + + F g +f V d++ +++ mKIAA1846 298 LVHTQAGYLLYAAMTHKL-VFDYQPGDVF---------GCVADIgwitgh 337 ....YPsLasGGTLilLdKditn.nfKlLFeeLpktglNvWvSTPSFvdm + Y L G T +l ++ + ++ e+ + +N P v + mKIAA1846 338 syvvYGPLCNGATTVLFESTPVYpDAGRYWETVQRLKINQFYGAPTAVRL 387 CLL...DPnFnqEnyPqLthFlFCGEeLtkKTAkaLleRFPs..AtIYNT LL+ +D + +L + GE + + + L +++ t T mKIAA1846 388 -LLkygDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDgrCTLVDT 436 YGPTEATVAVTsVkIT.......qEildqyprLPiGfaKPDmnlfIvDeE TE T+ ++ I +++++++ Eil P + P +De mKIAA1846 437 WWQTE-TG---GICIAprpsedgAEILPGMAMRPFFGIVP----VLMDEK 478 GekLpeGe.kGEIvI..vGpSVSKGYLnNPEKTaeAFFevdGqrAYr.TG G++L G+ G + I+++ p ++ + + A F + +++Y TG mKIAA1846 479 GNVLEGGDvSGALCIsqAWPGMARTIYGDHQRFVDAYFRA--YPGYYfTG 526 DaGtitdgGmlFyQGRlDFQIKLnGYRIELEDIEanLrqssyIksAvvvP D + t gG+ + GR+D I G R +IE + + +v+ mKIAA1846 527 DGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIG 576 kynkdhKVeaLIAyvvpetGvfedfekEiqlTkaIKkELkkilmeYMIPr + d K ea A++v+++ + + + ++K + + Y P mKIAA1846 577 YP-HDIKGEAAFAFIVLKD---NISDENMVV-NELKLSVATKIAKYAVPD 621 KFiYrdqlPLTaNGKIDRKaLaeeVnk<-* ++ + lP T GK+ R L + mKIAA1846 622 QILVVKRLPKTRSGKVMRRLLRKIITS 648 Ac_CoA_lig_AcsA: domain 1 of 1, from 46 to 671: score 1463.5, E = 0 *->issleaYkklyeeaieDpekFWaklAreeLdWfkPFtkVldwsfppg ++++ Y +l ++a+ +p++FW+ lAr++L W++P+++V+d++f +g mKIAA1846 46 AAQPGSYPALSAQAAQEPAAFWGPLARDTLVWDTPYHTVWDCDFRTG 92 nvfakWFegGeLNvSYNCvDRHlekgrpdkvAIIWEGDPVepgePdsrki ++ WF+gG+LNvS+NC+D+H++k p+ +A+IWE D epg+ + +i mKIAA1846 93 --KIGWFLGGQLNVSVNCLDQHVQK-SPETIALIWERD--EPGT--EVRI 135 TYrELhreVCrfANvLK.lGVkKGDrVaIYMPMiPEaaiAMLACARIGAi TYrEL++ +Cr+AN+LK++GV++GDrVaIYMP +P a++AMLACARIGAi mKIAA1846 136 TYRELLETTCRLANTLKrHGVHRGDRVAIYMPVSPLAVAAMLACARIGAI 185 HSVVFgGFSAeALadRInDAgaKlVITADeglRGGKvipLKaiVDeALek H+VVF+GFSAe+La+RInDA++K+VIT+++glRGG+v++LK+iVDeA++ mKIAA1846 186 HTVVFAGFSAESLAGRINDAKCKAVITFNQGLRGGRVVELKKIVDEAVKS 235 cpdtcpsVekVLVvrRTGgpvvpWveGRDvWwhelvakgqsaeCePEpMd cp +V++VLV +RT+ +v+ + + D+ ++++ak + + C+PE+M mKIAA1846 236 CP----TVQHVLVAHRTDTKVP-MG-SLDIPLEQEMAK-EAPVCTPESMS 278 SEDPLFiLYTSGSTGKPKGVlHTTGGYLLyAamTmkyVFDikdgDifWCT SED+LF+LYTSGSTG+PKG +HT++GYLLyAamT+k+VFD+++gD+f+C mKIAA1846 279 SEDMLFMLYTSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYQPGDVFGCV 328 ADVGWITGHSYiVYGPLanGATtlmFEGvPtYPdagRfWeiIEkHkVtiF AD+GWITGHSY+VYGPL+nGATt++FE++P+YPdagR+We++++ k+++F mKIAA1846 329 ADIGWITGHSYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQF 378 YTAPTAIRaLmrlGdewvkKhDlSSLRlLGSVGEPINPEAWmWYykvVGk Y APTA+R+L ++Gd+wvkK+D+SSLR LGSVGEPIN EAW+W +kvVG+ mKIAA1846 379 YGAPTAVRLLLKYGDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGD 428 erCpIVDTWWQTETGGimItPLPGa.atptKPGSATlPffGIepavvDPe +rC +VDTWWQTETGGi+I+P P ++ +++ PG+A++PffGI+p+++D e mKIAA1846 429 GRCTLVDTWWQTETGGICIAPRPSEdGAEILPGMAMRPFFGIVPVLMD-E 477 eGkeveGpgeggaGyLvIkqPWPsMlRTIyGDheRfveTYfspfpgkGky +G+++eG +++ G+L+I+q WP+M+RTIyGDh+Rfv+ Yf +pg y mKIAA1846 478 KGNVLEGGDVS--GALCISQAWPGMARTIYGDHQRFVDAYFRAYPG---Y 522 YFTGDGArRDkDGYiWItGRvDDViNVSGHRLGTaEIESALVsHpaVAEA YFTGDGA+R + GY++ItGR+DDViN+SGHRLGTaEIE+A+++HpaV+E mKIAA1846 523 YFTGDGAHRTEGGYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPET 572 AVVGipDdiKGqaiyAFVtLkdgvepdd..LrkELrkhVrkeIGpiAkPd AV+G+p+diKG+a +AF++Lkd+++ d++ +++EL+ V+++I ++A Pd mKIAA1846 573 AVIGYPHDIKGEAAFAFIVLKDNIS-DEnmVVNELKLSVATKIAKYAVPD 621 eIrfvpgLPKTRSGKIMRRlLRkIAegeleilGDtSTLeDPsvveeliea +I++v++LPKTRSGK+MRRlLRkI++++ + lGDt+TLeDPsv+ e+ +a mKIAA1846 622 QILVVKRLPKTRSGKVMRRLLRKIITSRGQDLGDTTTLEDPSVITEILSA 671 <-* mKIAA1846 - - propion_prpE: domain 1 of 1, from 46 to 674: score 465.4, E = 4.8e-136 *->mPmsmaYeefyqRSIeePeaFWaEQAr.rIdWqTPyarvLD.dsnpP +Y ++ eP+aFW+ Ar+ W TPy v D d + mKIAA1846 46 AAQPGSYPALSAQAAQEPAAFWGPLARdTLVWDTPYHTVWDcDFRTG 92 FarWFvgGrTNLChNAvDRhLekrgeqlALvavSsETgeertytYRqlHr WF gG+ N N +D h +k +e +AL+ E g e tYR l + mKIAA1846 93 KIGWFLGGQLNVSVNCLDQHVQKSPETIALIWERDEPGTEVRITYRELLE 142 EVNavAsalraLGVrRGDRVliYmPmiaEAvfamLACARIGAiHSVVFGG ++A l+ GV RGDRV iYmP + Av amLACARIGAiH VVF G mKIAA1846 143 TTCRLANTLKRHGVHRGDRVAIYMPVSPLAVAAMLACARIGAIHTVVFAG 192 FAshslAlRIDDAtPklivsADAGaRGGKvipYKpLlDaAiaeAqhkPaH F + slA RI DA+ k ++ G RGG+v++ K+ +D+A+ +H mKIAA1846 193 FSAESLAGRINDAKCKAVITFNQGLRGGRVVELKKIVDEAVKSCPTV-QH 241 VLlVdRgLapdlrrvpGrDvDYAaLrrQHedAqVpv.eWLESnEpSyiLY VL+ R + vp D +A V +e + S ++LY mKIAA1846 242 VLVAHRTDTK----VPMGSLDIPLEQEMAKEAPVCTpESMSSEDMLFMLY 287 TSGTTGKPKGVQRDvGGYAVaLAlSMdaIfgakAGdvmFsaSDvGWvVGH TSG TG PKG GY A+ ++f+ + Gdv+ + D+GW+ GH mKIAA1846 288 TSGSTGTPKGLVHTQAGYLLYAAMTHKLVFDYQPGDVFGCVADIGWITGH 337 SYiVYaPLlAGlatvlYEGlPtrPDggvWWsIvEkYrVrvMFsaPTaIRV SY+VY+PL G++tvl+E +P+ PD g W v + +++ + aPTa+R mKIAA1846 338 SYVVYGPLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRL 387 LKKqdaAllrkHDLSsLevLfLAGEPLDEPTArWisdalg...kpvIDNY L K+ A+++k D SsL+ L GEP W +g+++ + +D + mKIAA1846 388 LLKYGDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGdgrCTLVDTW 437 WQTEtGWPvLAiarGlddkpvklGSPGlPmyGYrldvldEaTGrpcgpnE WQTEtG +A + d G P +G ++dE g mKIAA1846 438 WQTETGGICIAPRPSEDGAEILPGMAMRPFFGIVPVLMDEKGNVLEGGDV 487 KGlLvvaaPLPPGClsTvWgDDaRFlktYwslFkGrplYssfDWgiRDed G L + PG T+ gD RF+ Y+ +++ Y + D + R e mKIAA1846 488 SGALCISQAW-PGMARTIYGDHQRFVDAYFRAYP--GYYFTGDGAHRTEG 534 GYifILGRTDDVINVAGHRLGTREIEESvsSHpavAEvAVvGVkDeLKGQ GY I GR DDVIN+ GHRLGT EIE ++ Hpav E AV+G + KG mKIAA1846 535 GYYQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGYPHDIKGE 584 VavaFailkeadrvedaddahalekelmalVesQlGavaRParVyfVaaL a aF++lk ++ d + el V + a P ++ +V L mKIAA1846 585 AAFAFIVLK-----DNISDENMVVNELKLSVATKIAKYAVPDQILVVKRL 629 PKTRSGKLLRRaiQAvaEgR..DPGDLtTidDPaaLeqvRrAlee<-* PKTRSGK +RR + + +R++D GD tT++DP ++ A ++ mKIAA1846 630 PKTRSGKVMRRLLRKIITSRgqDLGDTTTLEDPSVITEILSAFQK 674 ac_ac_CoA_syn: domain 1 of 1, from 20 to 680: score -83.5, E = 2.3e-14 *->ErpEimECQvLWePDaeivkdarmarFrawvgerfGlPAlGdYdaLh r Q W + v ++ +r v + G Y aL mKIAA1846 20 GRS----GQSGW---SLSVSRSTATRLPGCVPAAAQP---GSYPALS 56 dWSVdeldaFWkavwefsdVvfssgekevvDddkmldarPEwFpgArLNY +e aFW v +++ v D d + wF g LN mKIAA1846 57 AQAAQEPAAFWGPLAR-DTLVWDTPYHTVWDCDFRTGKI-GWFLGGQLNV 104 AEnlL.RkkgsRPDedalLY.vdeeGRkesakvTweELRrqVArLaaaLR n L+ + P+ al++++de G ++ ++T+ EL rLa L mKIAA1846 105 SVNCLdQHVQKSPETIALIWeRDEPGTEV--RITYRELLETTCRLANTLK 152 alGVkkGDRVaGyLPNipeAVaamLAtAsVGAiWsScsPDFGargVLDRF GV GDRVa y+P +p AVaamLA A +GAi + F a + R mKIAA1846 153 RHGVHRGDRVAIYMPVSPLAVAAMLACARIGAIHTVVFAGFSAESLAGRI 202 sQiePkllfsvdGyvYnGKehDrrekvrevakeLPdLravVliPyvgdre + k ++ +G + v e +k+ P+ + v +v mKIAA1846 203 NDAKCKAVITFNQGLRGGRVVELKKIVDEAVKSCPTVQHV----LVA--H 246 klapskvd.gald..LedflAaGtGaQaaeLvFEqlPFdHPLyiLFSSGT + kv+ g+ld +Le +A a+ E + L+ L+ SG mKIAA1846 247 RTDT-KVPmGSLDipLEQEMAK----EAPVCTPESMSSEDMLFMLYTSGS 291 TGvPKciVhSaGGtLvqHLKehrLHCdLrdgdrLfYYTtvGWMM.WNwLv TG PK +Vh + G L+ h L d +gd + +GW + + v mKIAA1846 292 TGTPKGLVHTQAGYLLYAAMTHKLVFDYQPGDVFGCVADIGWITgHSYVV 341 SG.LatGAtLvLYDGSPlvPatnvlwdlaeregitvfGTSAkYvsavrka G+L GAt vL+ P P+ w + r i f v + k mKIAA1846 342 YGpLCNGATTVLFESTPVYPDAGRYWETVQRLKINQFYGAPTAVRLLLKY 391 gvkParthdLsaLrlvasTGSPLkpegFeyvYeeikaGGAdv...lLASi g + d s+Lr+ s G P e +e+++ + G ++ +++ mKIAA1846 392 GDAWVKKYDRSSLRTLGSVGEPINHEAWEWLHKVVGDGRCTLvdtWWQTE 441 SGGTDivSCFvganpllPVykGEiQApgLGlaveaWdeeGkpvrg..ekG GG i+ + G p G+ de G+ + g++ +G mKIAA1846 442 TGG--ICIAPRPSEDGAEILPGMAMRPFFGIVPVLMDEKGNVLEGgdVSG 489 ELVcTkpiPSmPvrFWNDpdGSkYrkAYFdkYpgVWaHGDyieltpKrGg L + ++ P m D ++ +AYF Ypg GD + t G mKIAA1846 490 ALCISQAWPGMARTIYGDHQ--RFVDAYFRAYPGYYFTGDGAHRTE-GGY 536 iVihGRSDaTLNpqGVRiGsAeIYnaVErlDEVeeSLciGqeqeDGdvRv i GR D N G R+G+AeI +a + V e +iG ++ mKIAA1846 537 YQITGRMDDVINISGHRLGTAEIEDAMADHPAVPETAVIGYPHDIKGEAA 586 vLFvkLAsGatLddaLvkrIkdaIRaglSpRHVPdkiievagIPrTlsGK F+ L + v + k + VPd+i+ v P T sGK mKIAA1846 587 FAFIVLKDNISDENMVVNELKLSVATKIAKYAVPDQILVVKRLPKTRSGK 636 kVEvAVkdvv..aGkpveKAvnkgAldNp....eaLdLYeeLeelks<-* ++++++ G+ + l p+ +e L ++ ee + mKIAA1846 637 VMRRLLRKIItsRGQDLG---DTTTLEDPsvitEILSAFQKYEEQRA 680 //