hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/meh/meh03138/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1804 ( 807 res) meh03138 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 277.9 1.3e-79 1 Pkinase_Tyr Protein tyrosine kinase 264.3 1.6e-75 1 SH3_1 SH3 domain 56.3 6.4e-13 1 SH3_2 Variant SH3 domain 46.4 6.2e-10 1 APH Phosphotransferase enzyme family -15.6 0.46 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- SH3_1 1/1 43 102 .. 1 58 [] 56.3 6.4e-13 SH3_2 1/1 44 102 .. 1 69 [] 46.4 6.2e-10 APH 1/1 127 321 .. 1 256 [] -15.6 0.46 Pkinase 1/1 126 398 .. 1 287 [] 277.9 1.3e-79 Pkinase_Tyr 1/1 126 398 .. 1 272 [] 264.3 1.6e-75 Alignments of top-scoring domains: SH3_1: domain 1 of 1, from 43 to 102: score 56.3, E = 6.4e-13 *->kkvvALYDYearesdELsFkkGDvitvleksdd.....gWWkgrlkg + ALYDYear++dELs+++G ++vl+++ + ++++gWW g+++ mKIAA1804 43 GMWAALYDYEARGEDELSLRRGQLVEVLSQDAAvsgdeGWWAGQVQ- 88 tgGkeGliPsNYVepv<-* + G++P++YV+p mKIAA1804 89 --RRLGIFPASYVAPC 102 SH3_2: domain 1 of 1, from 44 to 102: score 46.4, E = 6.2e-10 *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskddd.... + a+ dy+a ++++e Lsl++G++v+v+ s+d +++ mKIAA1804 44 MWAALYDYEA-RGEDE------LSLRRGQLVEVL----SQDAAvsgd 79 .gwwlgeslggGrrrRGlvPssaveel<-* +gww g + +r G +P+s+v+++ mKIAA1804 80 eGWWAGQV--QRRL--GIFPASYVAPC 102 APH: domain 1 of 1, from 127 to 321: score -15.6, E = 0.46 *->elrplsgGasnrtylvttgd.gdapryvlrlappg......eaaeel el++l g + +++ t +++ ++ ++ a+++++++ +aae++ mKIAA1804 127 ELKELIGAGGFGQVYRATWQgQ---EVAVKAARRDpeqdaaAAAESV 170 erEaavlrhLaalgipvpvpvPrvlaggtdgeglglpfllleglpGevls +rEa++++ L+ i + ++ + ++ + +l l +le+ G l mKIAA1804 171 RREARLFAMLRHPNI-----I-QLRGVCLRQPHLCL---VLEFARGGALN 211 rpnalspaerpallealarlLarLHqvdppalplarrlerrlkllrqlaa r +++++a + ++ + a mKIAA1804 212 R------------------------ALAAAASDPRAPG--------PRRA 229 ala.rlvaaelldeerglllelaerllaaleallpppvlvHGDlhpgNvl ++++++v + + + ++ + l+ + ea +p ++H+Dl + N+l mKIAA1804 230 RRIpPQVLVNWAV-----QIARGM-LYLHEEAVVP---ILHRDLKSSNIL 270 vddapdggrvsGvIDfedaglGdpayDlAmllrslfgeefgpefldayla + + ++ + + + D++ + + + +++ + +y+ mKIAA1804 271 LL--EKIEHD------DICNKTLKITDFGLAR-E-WHRTTRMSAAGTYAW 310 aygrqfaapglerlrel<-* p+ r ++ mKIAA1804 311 MA------PEVIRSSLF 321 Pkinase: domain 1 of 1, from 126 to 398: score 277.9, E = 1.3e-79 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar +el+e +G+G+fG+Vy+a+++g + VAvK +++++++ + + mKIAA1804 126 LELKELIGAGGFGQVYRATWQGQE--VAVKAARRDpEQDAAAAAESV 170 rrsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdyls rr E+++ ++L+HpNI++l++v+ + +hl+lVlE+++gG L ++l mKIAA1804 171 RR-EARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARGG----ALNRALA 215 ......e...trrkgpllfsedeakkialQilrgleYLHsn...giiHRD ++++ ++ rr +++ +++++ ++a Qi+rg+ YLH++ i+HRD mKIAA1804 216 aaasdpRapgPRRARRI--PPQVLVNWAVQIARGMLYLHEEavvPILHRD 263 LKPeNILldengvvda....flKiaDFGlAkklst.sss.lttfvGTpwY LK++NILl e+ + d+ +++lKi+DFGlA+ + + ++ ++ +GT+ + mKIAA1804 264 LKSSNILLLEKIEHDDicnkTLKITDFGLAR---EwHRTtRMSAAGTYAW 310 mAPEvllggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlir mAPEv++ ++ ++ +D+WS+Gv+l+elltG+ P++g d l++ + mKIAA1804 311 MAPEVIR-SSLFSKGSDIWSYGVLLWELLTGEVPYRGI-----DGLAVAY 354 kilgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlta + +l ++p +++ e++ +L+k c+++DP+ R+++ mKIAA1804 355 GVAVNKLTLPIPSTCP-------------EPFAKLMKECWEQDPHIRPSF 391 eeilqHPwf<-* + ilq + mKIAA1804 392 ALILQQ--L 398 Pkinase_Tyr: domain 1 of 1, from 126 to 398: score 264.3, E = 1.6e-75 *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtLk....eigass l+l + +G+G FG Vy++t+ +++VAVK ++++++ +a mKIAA1804 126 LELKELIGAGGFGQVYRATWQ------GQEVAVKAARrdpeQ-DAAA 165 eeieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEyme + e+ rEA++ l +HpNi++L Gvc+ ++P+ l++V+E++ mKIAA1804 166 AA---ESVRREARLFAML-RHPNIIQLRGVCL--RQPH---LCLVLEFAR 206 gGdLldfLrkhr.........egrpLtlkdLlsfalQiAkGMeYLes... gG L L + ++++ ++++ r+++ + L+++a+QiA+GM YL+++ mKIAA1804 207 GGALNRALAAAAsdprapgprRARRIPPQVLVNWAVQIARGMLYLHEeav 256 knfvHRDLAARNcLVse........nlvVKIsDFGLaRdiynddyYvrkk ++ HRDL N+L+ e+ ++++ n++ KI+DFGLaR r++ mKIAA1804 257 VPILHRDLKSSNILLLEkiehddicNKTLKITDFGLAREW-----H-RTT 300 gggk.lPvkWmAPEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgms + WmAPE+++ + F+ SD+WS+GVlLWE++t Ge P Y g++ mKIAA1804 301 RMSAaGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLT-GEVP-YRGID 348 neevlellyedGyRLprPenCPdelYdlMlqCWaedPedRPtFselverL v ++ + Lp+P CP+ +lM++CW+ dP RP+F+ ++++L mKIAA1804 349 GLAVAYGVAVNKLTLPIPSTCPEPFAKLMKECWEQDPHIRPSFALILQQL 398 <-* mKIAA1804 - - //