hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mpf/mpf00986/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1790 ( 1898 res) mpf00986 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 139.2 7.5e-38 1 LRR_1 Leucine Rich Repeat 96.4 5.7e-25 13 Pkinase_Tyr Protein tyrosine kinase 83.4 4.5e-21 1 Ank Ankyrin repeat 19.3 0.094 3 Arf ADP-ribosylation factor family -87.1 0.032 1 Ras Ras family -92.3 0.15 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Ank 1/3 3 33 .. 1 33 [] 0.9 1.5e+02 Ank 2/3 36 69 .. 1 33 [] 15.5 1.2 Ank 3/3 77 109 .. 1 33 [] 3.1 71 LRR_1 1/13 163 186 .. 1 25 [] 7.9 98 LRR_1 2/13 187 208 .. 1 25 [] 14.0 3.6 LRR_1 3/13 214 236 .. 1 25 [] 16.6 0.61 LRR_1 4/13 237 258 .. 1 25 [] 3.2 5.9e+02 LRR_1 5/13 265 288 .. 1 25 [] 16.4 0.7 LRR_1 6/13 289 312 .. 1 25 [] 12.1 14 LRR_1 7/13 335 357 .. 1 25 [] 5.6 2.4e+02 LRR_1 8/13 358 381 .. 1 25 [] 2.2 8.5e+02 LRR_1 9/13 382 401 .. 1 25 [] 10.4 38 LRR_1 10/13 433 455 .. 1 25 [] 12.5 10 LRR_1 11/13 456 479 .. 1 25 [] 14.8 2.1 LRR_1 12/13 480 502 .. 1 25 [] 0.7 1.5e+03 Arf 1/1 508 706 .. 1 186 [] -87.1 0.032 Ras 1/1 524 712 .. 1 174 [] -92.3 0.15 LRR_1 13/13 1068 1090 .. 1 25 [] 6.2 1.9e+02 Pkinase 1/1 1126 1404 .. 1 287 [] 139.2 7.5e-38 Pkinase_Tyr 1/1 1117 1404 .. 1 272 [] 83.4 4.5e-21 Alignments of top-scoring domains: Ank: domain 1 of 3, from 3 to 33: score 0.9, E = 1.5e+02 *->dGfTPLHlAalrgnlevvklLlsqGAdlnaqdd<-* + P +Aa+ g++evv++Ll+ + + mKIAA1790 3 TDDNPAVVAAHFGHAEVVRELLE--SLPGPCTP 33 Ank: domain 2 of 3, from 36 to 69: score 15.5, E = 1.2 *->dGfTPLHlAalrgnlevvklLls.qGAdlnaqdd<-* + L lA++rg+levvklL+ ++GAd+ mKIAA1790 36 LLNWMLALACQRGHLEVVKLLVLtHGADPENYAV 69 Ank: domain 3 of 3, from 77 to 109: score 3.1, E = 71 *->dGfTPLHlAalrgnlevvklLlsqGAdlnaqdd<-* + PL A++ gn++++ +Ll +GA + mKIAA1790 77 IVRLPLYAAIKAGNEDIAIFLLRHGAYFCSYIL 109 LRR_1: domain 1 of 13, from 163 to 186: score 7.9, E = 98 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +++eLdLs N l +slp+ gl mKIAA1790 163 QITELDLSA-N-CL-PSLPSIiPwGLI 186 LRR_1: domain 2 of 13, from 187 to 208: score 14.0, E = 3.6 *->nLeeLdLsgCNpslsgslppsl.glp<-* nL++L+Ls+ N +l g+lp ++ mKIAA1790 187 NLKKLNLSN-N-QL-GELPC-VqSSD 208 LRR_1: domain 3 of 13, from 214 to 236: score 16.6, E = 0.61 *->nLeeLdLsgCNpslsgslppsl.glp<-* +L e+d+s+ N +ls +lpp++ +l+ mKIAA1790 214 RLLEIDISS-N-KLS-HLPPGFlHLS 236 LRR_1: domain 4 of 13, from 237 to 258: score 3.2, E = 5.9e+02 *->nLeeLdLsgCNpslsgslppslglp<-* +L++L s N +l++ ++++ + + mKIAA1790 237 KLQKLTASK-N-YLERLFEEE-NAT 258 LRR_1: domain 5 of 13, from 265 to 288: score 16.4, E = 0.7 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L+eLdL + N +l+ +lp ++++ mKIAA1790 265 KLQELDLAD-N-RLT-ELPVQfMhSFK 288 LRR_1: domain 6 of 13, from 289 to 312: score 12.1, E = 14 *->nLeeLdLsgCNpslsgslpps.l.glp<-* +L++L++s+ N +l +s+p+ l+ mKIAA1790 289 SLTSLNVSR-N-NL-KSFPDPwScPLK 312 LRR_1: domain 7 of 13, from 335 to 357: score 5.6, E = 2.4e+02 *->nLeeLdLsgCNpslsgslppsl.glp<-* +L+ d+s N sl +++p +l l mKIAA1790 335 HLRDADFSE-N-SL-KEVPLGLfQLD 357 LRR_1: domain 8 of 13, from 358 to 381: score 2.2, E = 8.5e+02 *->nLeeLdLsgCNpslsgslpps.l.glp<-* L L+L+g N +l slpp ++ mKIAA1790 358 ALMFLRLQG-N-QLL-SLPPQeKwTCT 381 LRR_1: domain 9 of 13, from 382 to 401: score 10.4, E = 38 *->nLeeLdLsgCNpslsgslppslglp<-* +L++LdLs+ N +l g ++ gl+ mKIAA1790 382 QLKTLDLSR-N-QL-GKNED--GLK 401 LRR_1: domain 10 of 13, from 433 to 455: score 12.5, E = 10 *->nLeeLdLsgCNpslsgslppsl.glp<-* +Le+L L++ N +l + +pps l+ mKIAA1790 433 SLEVLCLND-N-HL-DAVPPSVcLLK 455 LRR_1: domain 11 of 13, from 456 to 479: score 14.8, E = 2.1 *->nLeeLdLsgCNpslsgslppsl.glp<-* nL eL+L++ Np l ++lpp+l+ l mKIAA1790 456 NLSELYLGN-NPGL-RELPPELgQLG 479 LRR_1: domain 12 of 13, from 480 to 502: score 0.7, E = 1.5e+03 *->nLeeLdLsgCNpslsgslppsl.glp<-* nL Ld+++ ++s +p++ ++ mKIAA1790 480 NLWQLDIED-L-NIS-NVPAEVrKEG 502 Arf: domain 1 of 1, from 508 to 706: score -87.1, E = 0.032 *->gflkiflkllglwnKEmRILiLGLDnAGKTTILykLklge...vvtt +fl+ l + K m+++++G GK+T+L L++g+ +++++ mKIAA1790 508 SFLRAQLRKAEK-CKLMKMILVGPPRQGKSTLLEILQTGKapqLAHS 553 iPTiGFNvEtveykn........vkFtvWDvGGQeslRPlWrnYfpnTda Ti + +++ +++ + ++v F+vWD+GG s + + f + a mKIAA1790 554 EATIRTTKWELQRPAgskakvesVEFNVWDIGGPASMATVNQCFFTD-KA 602 vIfVVDSaDrdRieeakeELh.aLLneeeL.adaplLilANKQDlpgAls + VV eea L+ LLn+e +a++L+++ Dl +A+ mKIAA1790 603 LYVVVWNLALG--EEAVANLQfWLLNIEAKaPNAVVLVVGTHLDLIEAKF 650 eaE.....ireaLgLhelkgskgkVtl.e.gdRpWeiqgcsAvkGeGLyE E+ + +++ L L + ++ ++ +++ + c + G+ E mKIAA1790 651 RVEriatlRAYVLALCRSPSGSRATGFpDiTFKHLHEISCKNLEGQ---E 697 GldWLsnni<-* Gl+ L+ + mKIAA1790 698 GLRQLIFHV 706 Ras: domain 1 of 1, from 524 to 712: score -92.3, E = 0.15 *->KlVlvGDgGVGKSsLliRFtdnkFpe..eYipTIGvDFytktvevd. K +lvG GKS+Ll ++k p+ ++++TI t e+ + mKIAA1790 524 KMILVGPPRQGKSTLLEILQTGKAPQlaHSEATI----RTTKWELQr 566 .......gktvkLqIWDTAGQErFralrpaYYRgAqGfLLVYDITs.rdS + +++ + + v++ +WD G ++ ++ + ++V +++ mKIAA1790 567 pagskakVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALgEEA 616 FenvkkWleeilrhadkdenvpivLVGNKcDLeddedlele.kqkRqVst n++ Wl +i+ a+ n +++ VG+ DL + ++ + + t mKIAA1790 617 VANLQFWLLNIEAKAP---NAVVLVVGTHLDLIE-----AKfRV-ERIAT 657 eeGealA.....................kelgAlpFmETSAKtneNVeea ++ lA +++++++ ++ ++ + ++ e+ ++ +E +e+ + mKIAA1790 658 LRAYVLAlcrspsgsratgfpditfkhlHEIS-CKNLE----GQEGLRQL 702 Feelareilk<-* + ++ +++ mKIAA1790 703 IFHVTCNMKD 712 LRR_1: domain 13 of 13, from 1068 to 1090: score 6.2, E = 1.9e+02 *->nLeeLdLsgCNpslsgslppsl.glp<-* ++++ d+++C l+ ++ ++ ++p mKIAA1790 1068 SVQYFDMEDC--VLT-AIERDFiSCP 1090 Pkinase: domain 1 of 1, from 1126 to 1404: score 139.2, E = 7.5e-38 *->yelleklGsGsfGtV.ykakhkgtgkiVAvKiikkrkekskkdktar ++lG+G++GtV y+a+ +g + VAvK++ +k k + + a mKIAA1790 1126 EGENSILGQGGSGTViYQARYQGQP--VAVKRFHIKKFKNSANAPAD 1170 rr.................sEiqilkrLsHpNIvrlidvfedkdhlylVl ++ + + ++ ++ + E+++l+ L+Hp+Iv li++ + l++ l mKIAA1790 1171 TMlrhlramdamknfsdfrQEASMLHALQHPCIVSLIGISIHP--LCFAL 1218 EycegGLrlldLfdylse...trrkgpllfsedeakkialQilrgleYLH E+++ G +L ++lse+ ++++ pl +kia+Qi++gl+YLH mKIAA1790 1219 ELAPLG----SLNTVLSEnakDSSFMPL--GHMLTQKIAYQIASGLAYLH 1262 sngiiHRDLKPeNILl.....dengvvdaflKiaDFGlAkklst.sss.l +++ii +DLK++NIL+ + + +e+ ++ K++D G+++ + +++ mKIAA1790 1263 KKNIIFCDLKSDNILVwslsaKEHINI----KLSDYGISR---QsFHEgA 1305 ttfvGTpwYmAPEvllggngygtkvDvWSlGvilyelltGkpPFsgevqd ++ GTp+Y APE+ + y+ kvD++S+G +lyell+G+ P g+ mKIAA1790 1306 LGVEGTPGYQAPEIRP-RIVYDEKVDMFSYGMVLYELLSGQRPALGH--- 1351 sldqlqlirkilgpplefdspewdsisrsefrrlpnlseeakdLikkcLn qlq+++k +++ + + + ++ L+ c++ mKIAA1790 1352 --HQLQIVKKLSKGIRPVLGQPEEVQF-----------HRLQALMMECWD 1388 kDPskRltaeeilqHPwf<-* +P+kR+ a ++ + mKIAA1790 1389 TKPEKRPLALSVVSQ--M 1404 Pkinase_Tyr: domain 1 of 1, from 1117 to 1404: score 83.4, E = 4.5e-21 *->lklgkk.........LGeGaFGeV.ykGtlkgsgegtkikVAVKtLk l+ k ++++++++ LG+G G+V y++++ +++VAVK mKIAA1790 1117 LENSKLehtegensiLGQGGSGTViYQARYQ------GQPVAVKRFH 1157 .....................eigasseeieredFlrEAsiMkklGdHpN ++ +++ + + ++ ++ + +a+ dF +EAs++ l +Hp mKIAA1790 1158 ikkfknsanapadtmlrhlraM-DAMKN---FSDFRQEASMLHAL-QHPC 1202 iVrLlGvctkegePggpglyiVtEymegGdLldfLrkhr...egrpLtlk iV+L+G+ ++ P l+ +E++++G+L + L ++ ++++ pL mKIAA1790 1203 IVSLIGISIH---P----LCFALELAPLGSLNTVLSENAkdsSFMPLGHM 1245 dLlsfalQiAkGMeYLesknfvHRDLAARNcLVse....nl.vVKIsDFG ++a+QiA+G++YL+ kn++ DL N+LV + + +++ +K sD G mKIAA1790 1246 LTQKIAYQIASGLAYLHKKNIIFCDLKSDNILVWSlsakEHiNIKLSDYG 1295 LaRdiynddyYvrkkgggklPvkWmAPEslkygk.FtskSDVWSFGVlLW +R+ ++++ + g APE ++ ++ + +k D S+G +L+ mKIAA1790 1296 ISRQSFHEGAL-GVEG----TPGYQAPE-IRPRIvYDEKVDMFSYGMVLY 1339 EiftlGeqPFYpgmsneevlellyedGyRLprPenCPde.....lYdlMl E+++ G+ P g +++++l +G R + P+e + ++l lM+ mKIAA1790 1340 ELLS-GQRP-ALGHHQLQIVKKL-SKGIRPVLGQ--PEEvqfhrLQALMM 1384 qCWaedPedRPtFselverL<-* +CW+ +Pe+RP +v+++ mKIAA1790 1385 ECWDTKPEKRPLALSVVSQM 1404 //