hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpm/mpm10162/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1748  ( 800 res)   mpm10162

Scores for sequence family classification (score includes all domains):
Model        Description                                Score    E-value  N 
--------     -----------                                -----    ------- ---
zf-DHHC      DHHC zinc finger domain                    120.0    4.4e-32   1
Tetraspannin Tetraspanin family                         -60.3       0.55   1
Extensin_2   Extensin-like region                      -143.6       0.73   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
zf-DHHC        1/1     180   244 ..     1    66 []   120.0  4.4e-32
Tetraspannin   1/1      54   257 ..     1   291 []   -60.3     0.55
Extensin_2     1/1     317   645 ..     1   385 []  -143.6     0.73

Alignments of top-scoring domains:
zf-DHHC: domain 1 of 1, from 180 to 244: score 120.0, E = 4.4e-32
                   *->ldndkfikdnfCskCnsyKVPpRShHCsvCnkCVlrmDHHCpWinnC
                      + +++  + ++C +C++y+ PpR++HCsvC++CV+ +DHHCpW+nnC
   mKIAA1748   180    EIKGIQVRMKWCATCRFYR-PPRCSHCSVCDNCVEEFDHHCPWVNNC 225  

                   VGlrNyryFllFlfylill<-*
                   +G+rNyryF+lFl++l+ +   
   mKIAA1748   226 IGRRNYRYFFLFLLSLTAH    244  

Tetraspannin: domain 1 of 1, from 54 to 257: score -60.3, E = 0.55
                   *->clKyllfllNflfwLlGilllgvGiWllvdkgsfssllgl.......
                      +l  +l+ ++ lf+ +    +g+G  + + +++ s++ ++++++ ++
   mKIAA1748    54    FLSVSLIPFSCLFCRC----VGLGYAAGHIFHQSSNMPAEsgkrfkp 96   

                   .ssscflaapyvlIlavGaviflvgflGccGAikEsrclLglYfifLlll
                   + + + +aa++ l+   Ga +++++f  c G    +  +  +Y  +++l+
   mKIAA1748    97 sKYVPVSAAAIFLV---GATTLFFAFT-CPGLSLNVSPAVPIYNAIMFLF 142  

                   filelaagilafvfrdvkvesel.getlkkalkkyydtddysawlqrVdk
                    ++ +      f+  +     ++++   ++   +  + + y         
   mKIAA1748   143 VLANFS--MATFMDPG-----IFpRAEEDEDKEDDFRAPLYK-------- 177  

                   WeIRsCLvdsvCnltadFFteawdalQsqfkCCGPPvnggfyytDTlWfp
                                      t  +  +Q         +          W  
   mKIAA1748   178 -------------------TVEIKGIQV--------RMK--------W-- 190  

                   qwssnyfsgnsevdriknvdcklwrn.v.vlCydcsv.a.nasg.kteee
                                       c++ r   + +C++csv +++ ++ +  ++
   mKIAA1748   191 --------------------CATCRFyRpPRCSHCSVcDnCVEEfDHHCP 220  

                   sprpcevsnctccppsseccqdapsniyteGCkekvleflrenlliiagv
                   +++ c+                      ++  +  +l  l+  ++i++++
   mKIAA1748   221 WVNNCI---------------------GRRNYRYFFLFLLSLTAHIMGVF 249  

                   aigiaviq<-*
                   ++g++ ++   
   mKIAA1748   250 GFGLLYVL    257  

Extensin_2: domain 1 of 1, from 317 to 645: score -143.6, E = 0.73
                   *->lltlvvalvslslpseasakYsYsSPPPpekpYvYkSPPpPspkyvy
                      ++      vs +l s++ + Y  +   P +++ +   PP   p   +
   mKIAA1748   317    FTNGCCNNVSRVLCSSPAPRYLGR---PKKEKTIVIRPPFLRP---E 357  

                   kSPPPpkkpY...................vYsSPPPPsyvykSPPPPkpy
                    S      +  +++ +++ ++++++++ ++ +S          PPPP   
   mKIAA1748   358 VSDGQITVKImdngiqgelrrtkskgsleITESQSAD----AEPPPP--- 400  

                   vYkSPPpPkyvYkSPPpPvykYkSPPPPthsppPpyvykSPPPPpk..ky
                                 P p    Y               + S    + ++  
   mKIAA1748   401 --------------PKPDLSRYTG----L------RTHLSLATNEDssLL 426  

                   vykSpPpptPvYkYkSPPPPpyvYkspPpPvkkripyvYk...SPPPPpP
                    + SpP pt  YkY+    P y   s  + +++    + ++++S   P+ 
   mKIAA1748   427 GKDSPPTPT-MYKYR----PGYSSSSTSAAMPHSSSAKLSrgdSLKEPTS 471  

                   YvYkSpPppvkkyiyksppppephkYvYkSPPPPpPYvyesvpeqkikYv
                    +  S   p+    y+s p  ep+   ++SP   +   ++ ++       
   mKIAA1748   472 -IADSSRHPS----YRSEPSLEPE--SFRSPTFGK-SFHFDPL------- 506  

                   YkSPPPPkksYkspsppkyVYkSpPpPvipykYkSPPPPkkkyspaPrkp
                               s    +   kS+   +  +         ++  +    +
   mKIAA1748   507 ------------SSGSRSSSLKSAQG-T-GFELG----QLQSIRSEGTTS 538  

                   yvYkSPPPPt....yvYkSpPpPykpptppkiyksPPPPtPvyvYkspPp
                     YkS    t++++  Y S   P+ +p    +   P P  P+  Y sp  
   mKIAA1748   539 TSYKSLANQTrngsLSYDSLLTPSDSPDFESVQAGPEPD-PPLGYTSPFL 587  

                   ippiksssppPvyvYkSpPppvysPPPPyvYssPPPPvyvynsaPvykks
                        s         +  P+  +  PP    + P P  y   s  +  + 
   mKIAA1748   588 -----SARLAQQREAERHPRLLPTGPPH---REPSPVRYDNLSRHIVASL 629  

                   PPkhhYiYsSPPPphh<-*
                     +      SPP       
   mKIAA1748   630 QEREKLLRQSPPLAGR    645  

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