hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpm/mpm03175/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1601  ( 856 res)   mpm03175

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
KE2         KE2 family protein                           51.5    1.8e-11   1
FHA         FHA domain                                   38.4    1.6e-07   1
Tropomyosin Tropomyosin                                 -75.8       0.88   1
Filament    Intermediate filament protein              -171.6        0.1   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
FHA           1/1      63   141 ..     1    94 []    38.4  1.6e-07
KE2           1/1     577   668 ..     1   106 []    51.5  1.8e-11
Tropomyosin   1/1     487   728 ..     1   237 []   -75.8     0.88
Filament      1/1     525   806 ..     1   359 []  -171.6      0.1

Alignments of top-scoring domains:
FHA: domain 1 of 1, from 63 to 141: score 38.4, E = 1.6e-07
                   *->vtiGRd.....sdsddilldddqdislsgsiSrrHatieykdggvsl
                      + iGR+  + +++++++ +d          +Sr+Ha++ ++ ++ ++
   mKIAA1601    63    IKIGRSvarcrPAQNNATFDCKV-------LSRNHALVWFDHKTSKF 102  

                   elafrlaqvkefgvylrDlssknlnGatfvNgkrl....gngepvrLksG
                                 yl+D +s+n  G tf+N +rl++++  ++p+++ sG
   mKIAA1601   103 --------------YLQDTKSSN--G-TFINSQRLsrgsEESPPCEILSG 135  

                   dvirlG<-*
                   d+i++G   
   mKIAA1601   136 DIIQFG    141  

KE2: domain 1 of 1, from 577 to 668: score 51.5, E = 1.8e-11
                   *->QelinkfqqLqqqleklaeqikqletqlkEielvleELelldedtkv
                      Q l+ ++q+L++++e+l+e++++      Ei ++++ L ++ ++   
   mKIAA1601   577    QVLQVQLQKLHMDMENLQEEKDT------EISSTRDKLLSAQDE--- 614  

                   YklvGgvLVkq.dkeevkeeLeerketlekeiktLekqleklekeleelk
                         +L++++  +e+++e +++  +l++e+k+++ +le ++k ++e++
   mKIAA1601   615 ------ILLLRqAAAEAVSERDTDFVSLQEELKKVRAELEGWRKAASEYE 658  

                   eelqkllgsa<-*
                    e+++l+ s+   
   mKIAA1601   659 NEIRSLQSSF    668  

Tropomyosin: domain 1 of 1, from 487 to 728: score -75.8, E = 0.88
                   *->KKlkqveneldkaqealkkaqekLeekekkltdAEaeVAalNRriql
                       K      +++  + +l++   k    +  l+ + +e  a    iq 
   mKIAA1601   487    EKSSDDTTDAQMDEQDLNEPLAKVSLLKDDLQGTQSETEAK-QDIQH 532  

                   vEEeLeraeERlatAlqKLeEAekaaDEseRgmKVlENRalkDEErmeil
                   +  eL  a+E   t  qK  E  +a  E eR  K   N   +   +  +l
   mKIAA1601   533 LRKELVEAQELARTSKQKCFE-LQALLEEER--KAYRNQVEESAKQIQVL 579  

                   enQLKEAkh....lAEeADrKydEVARKLaivEadL....ErAEeRaevg
                    +QL    ++ ++l Ee D+       KL    ++    +  A e +   
   mKIAA1601   580 QVQLQKLHMdmenLQEEKDTEISSTRDKLLSAQDEIlllrQAAAEAVSER 629  

                   EsKiveLEEELkvVgNnLKSLEvseEKasqredkYeeeiKtL..sdkLK.
                       v L EELk V   L       E   +   +Ye+ei+ L++s +L+ 
   mKIAA1601   630 DTDFVSLQEELKKVRAEL-------EGWRKAASEYENEIRSLqsSFQLRc 672  

                   ...EAEtRAEFAEr...sVqkLeKevDrLEDeLvaeKekYkaisdeLDqt
                   ++ E  +R E A r ++  +kL+Ke D LE e    K +++ +s eL   
   mKIAA1601   673 qqcEDQQREE-ATRlqgELEKLKKEWDVLETECHSLKKENVLLSSELQRQ 721  

                   lneLtgi<-*
                    +eL      
   mKIAA1601   722 EKELHNS    728  

Filament: domain 1 of 1, from 525 to 806: score -171.6, E = 0.1
                   *->nEKeqmQnLNDRLAsYIdKVRfLEqqNkeLevkieelrqkqsrggpa
                      + K+++Q+L                 + + e++  ++  kq +    
   mKIAA1601   525    EAKQDIQHL----------------RKELVEAQELARTSKQKC---- 551  

                   svsrlyslYeteieeLRrqidqltnerarlqlEidnlrealedfrkKyed
                       l  l e+e    R+q+++ +++   lq+++ +l ++ e ++++  +
   mKIAA1601   552 --FELQALLEEERKAYRNQVEESAKQIQVLQVQLQKLHMDMENLQEEKDT 599  

                   KeDLaaQnqlkdlEialntkeaeLaTaLeRqeaEndlvgLRaQiAklEsl
                                Ei          T     +a +++  L          
   mKIAA1601   600 -------------EISS--------TRDKLLSAQDEILLL---------- 618  

                   aaRkdlDeaTLar.vDLEnkvEsLqE...ElaFLKk...nHeEEvkeLqa
                     R+   ea   r++D+    E L+  + El+  +k  + +e E++ Lq+
   mKIAA1601   619 --RQAAAEAVSERdTDFVSLQEELKKvraELEGWRKaasEYENEIRSLQS 666  

                   qiqdtgqvnVEmDaarqqEwklDLtkaLrEiRaQYEeiAeknrqeaEew.
                   + q +   +   D  r                    e A + + e+E+ +
   mKIAA1601   667 SFQLR--CQQCEDQQR--------------------EEATRLQGELEKLk 694  

                   .....YksKleeLqtaaarngealrsaKeEitElRRqiQsLeiELqslks
                   ++ +  ++ +  L+++ +  + +l++++ E++    q  +L+++L  l+ 
   mKIAA1601   695 kewdvLETECHSLKKENVLLSSELQRQEKELHNSQKQSFELTSDLSILQM 744  

                   qnasLErqlaElEeryeaelaqyqalisqlEeeLqqlreEMarqLrEYQe
                   +++ LE+q+  l+e++ +++a++  l+s+ E++  ++  E +     + e
   mKIAA1601   745 TRKELEKQVGSLKEQHLRDAADLKTLLSKAENQAKDVQKEYEKTQTVLSE 794  

                   LLdVKlaLDiEIATYRKLLEGEEsR<-*
                   L   Kl  ++           E ++   
   mKIAA1601   795 L---KLKFEM----------TEQEK    806  

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