hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpm/mpm02342/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1593  ( 1058 res)   mpm02342

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
HECT     HECT-domain (ubiquitin-transferase)            492.7   2.8e-144   1
RCC1     Regulator of chromosome condensation (RCC1)    192.6    6.3e-54   7

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RCC1       1/7       9    58 ..     1    68 []     6.7     0.88
RCC1       2/7      61   108 ..     1    68 []    32.2  1.2e-05
RCC1       3/7     111   161 ..     1    68 []    52.2  1.1e-11
RCC1       4/7     166   214 ..     1    68 []    40.0  5.3e-08
RCC1       5/7     217   266 ..     1    68 []    35.4  1.3e-06
RCC1       6/7     269   318 ..     1    68 []    25.5   0.0012
RCC1       7/7     322   373 ..     1    68 []    13.5     0.16
HECT       1/1     760  1058 .]     1   366 []   492.7 2.8e-144

Alignments of top-scoring domains:
RCC1: domain 1 of 7, from 9 to 58: score 6.7, E = 0.88
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                          + +G   + +GqLGlg+  ee           l P        
   mKIAA1593     9    --SMLCWGN--ASYGQLGLGGIDEEIV---------LEPRRS----- 37   

                   ssslsekVvsvasGgqHtval<-*
                    +  + kV +v +G  Htv +   
   mKIAA1593    38 DFFVNKKVRDVGCGLRHTVFV    58   

RCC1: domain 2 of 7, from 61 to 108: score 32.2, E = 1.2e-05
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                      dG VY+ Gc  ++ GqLG    ++ +k          +P +v     
   mKIAA1593    61    DGTVYTCGC--NDLGQLG---HEKSRK----------KPEQV----- 87   

                   ssslsekVvsvasGgqHtval<-*
                           v va+G  Ht al   
   mKIAA1593    88 VALDAQNIVAVACGEAHTLAL    108  

RCC1: domain 3 of 7, from 111 to 161: score 52.2, E = 1.1e-11
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                       G+VY++G+  +  GqLGl +++e+ +          vP ++     
   mKIAA1593   111    KGQVYAWGL--DSDGQLGLQGSEECIR----------VPRNI----- 140  

                   ssslsekVvsvasGgqHtval<-*
                   +s  +   v+va+G +H  al   
   mKIAA1593   141 KSLSDIQIVQVACGYYHSLAL    161  

RCC1: domain 4 of 7, from 166 to 214: score 40.0, E = 5.3e-08
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                         V+ +G+  + +GqLGlg +  +            +P+l+     
   mKIAA1593   166    --EVFCWGQ--NKYGQLGLGIDCQKQT----------SPQLI----- 193  

                   ssslsekVvsvasGgqHtval<-*
                   +s l  ++ +va+Gg H ++l   
   mKIAA1593   194 KSLLGIPFMQVAAGGAHSFVL    214  

RCC1: domain 5 of 7, from 217 to 266: score 35.4, E = 1.3e-06
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                      +G ++++G+  +  GqLGl  e +             vP l+     
   mKIAA1593   217    SGAIFGWGR--NKFGQLGLNDENDRY-----------VPNLL----- 245  

                   ssslsekVvsvasGgqHtval<-*
                   +s +s k v   +G +Ht+al   
   mKIAA1593   246 KSLRSQKIVYICCGEDHTAAL    266  

RCC1: domain 6 of 7, from 269 to 318: score 25.5, E = 0.0012
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                      +G V+++G   g +GqLG   +  e             P +v     
   mKIAA1593   269    EGGVFTFGA--GGYGQLGHNSTSHEI-----------NPRKV----- 297  

                   ssslsekVvsvasGgqHtval<-*
                          V +va+G qHt a    
   mKIAA1593   298 FELMGSIVTQVACGRQHTSAF    318  

RCC1: domain 7 of 7, from 322 to 373: score 13.5, E = 0.16
                   *->dGrVYslGcFRgenGqLGlgeeveeskGGRqGLERLlvPvlvmLKsr
                      +Gr+Ys+G+  g nGqLG+g +   +           +P  v     
   mKIAA1593   322    SGRIYSFGL--GGNGQLGTGSTSNRK-----------SPFTV----- 350  

                   ssslsekVvsvas....GgqHtval<-*
                     +++  +  + ++++ G    +++   
   mKIAA1593   351 --KGNWFSYNGQCpqdiGSEDYFCV    373  

HECT: domain 1 of 1, from 760 to 1058: score 492.7, E = 2.8e-144
                   *->tLlsrelfnPdygLFeysdnseakseeddsysgyvedsytlfpnPls
                      +L++rel++P+yg+F+y                 +eds+ ++++   
   mKIAA1593   760    LLIMRELLDPKYGMFRY-----------------YEDSRLIWFSDKT 789  

                   gesnpehervlkyFkflGrilGlAlydgrllDlpFsraFyKklLmagkps
                   +e+       +++F+++G+i+GlA+y+++++Dl+F++a+yKklL  +++ 
   mKIAA1593   790 FED-------SDLFHLIGVICGLAIYNFTIVDLHFPLALYKKLL--KRK- 829  

                   igivtleDlesvDPelynSLkwllendgdKkIedsLLgsledveedLeLt
                      ++l+Dl++++P +++S+++ll++  d            d+ee+++L+
   mKIAA1593   830 ---PSLDDLKELMPAVGRSMQQLLDYPED------------DIEETFCLN 864  

                   FsveeessvgfeadarffGgtktveELkPnGrnipVTneNkeeYvelyvd
                   F++++e+   f       G t++ e L+ nG++++V+ +N++e+v++yvd
   mKIAA1593   865 FTITVEN---F-------GATEVKE-LVLNGADTAVNRQNRQEFVDAYVD 903  

                   yrLnkgiekQfeAFrkGFsevipsrlLslFdpeELelLicGspeeiDvdd
                   y++nk+++  f+AF+ GF++v+++++L lF+p+EL+ ++ G+  ++D+++
   mKIAA1593   904 YIFNKSVASLFDAFHAGFHKVCGGKVLLLFQPNELQAMVIGNT-NYDWKE 952  

                   LkenTeYdggYtedsplktiqwFWevleeftneeraklLqFvTGssRlPv
                   L++nTeY+g+Y++d+p  ti+ FWev++e++ e+++++L F TGs+R+P+
   mKIAA1593   953 LEKNTEYKGEYWADHP--TIKIFWEVFHELPLEKKKQFLLFLTGSDRIPI 1000 

                   gGFkaLqgGsnGpPkFtIvrkegggdddrLPtAhTCFNrLkLPpYsSkei
                   +G+k+L+        + I+ +  gg++++LP++hTCFN+L+LP+Y+ ke+
   mKIAA1593  1001 LGMKSLK--------LVIQST--GGGESYLPVSHTCFNLLDLPKYTEKET 1040 

                   LrekLllAInEgseGFgle<-*
                   Lr kL++AI  ++eGF+l    
   mKIAA1593  1041 LRCKLIQAI-DHNEGFSLI    1058 

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