hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbf/mbf00310/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1580  ( 640 res)   mbf00310

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
LRR_1    Leucine Rich Repeat                             95.9      8e-25   9
I-set    Immunoglobulin I-set domain                     52.8    7.3e-12   1
ig       Immunoglobulin domain                           34.4    2.6e-06   1
V-set    Immunoglobulin V-set domain                     34.2    2.9e-06   1
LRRNT    Leucine rich repeat N-terminal domain           25.8    0.00099   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
LRRNT      1/1      46    75 ..     1    34 []    25.8  0.00099
LRR_1      1/9      77   100 ..     1    25 []    11.4       21
LRR_1      2/9     101   124 ..     1    25 []    15.2      1.6
LRR_1      3/9     125   148 ..     1    25 []    16.1     0.85
LRR_1      4/9     149   172 ..     1    25 []    17.0     0.45
LRR_1      5/9     173   197 ..     1    25 []     9.8       49
LRR_1      6/9     198   219 ..     1    25 []     8.4       80
LRR_1      7/9     220   243 ..     1    25 []    19.1     0.11
LRR_1      8/9     244   267 ..     1    25 []     5.3  2.6e+02
LRR_1      9/9     268   291 ..     1    25 []    15.7      1.1
ig         1/1     368   428 ..     1    65 []    34.4  2.6e-06
I-set      1/1     354   444 ..     1    97 []    52.8  7.3e-12
V-set      1/1     352   444 ..     1   130 []    34.2  2.9e-06

Alignments of top-scoring domains:
LRRNT: domain 1 of 1, from 46 to 75: score 25.8, E = 0.00099
                   *->aCpapCtCserytdglvVdCsgrgLtvavPrdlP<-*
                       Cp  C Cs   +  ++V C +++L+ +vP++++   
   mKIAA1580    46    TCPSVCSCS---NQFSKVICVRKNLR-EVPDGIS    75   

LRR_1: domain 1 of 9, from 77 to 100: score 11.4, E = 21
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      n + L+L+  N +++  +  +++++l+   
   mKIAA1580    77    NTRLLNLHE-N-QIQ-IIKVNsFkHLR    100  

LRR_1: domain 2 of 9, from 101 to 124: score 15.2, E = 1.6
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +Le+L Ls+ N ++ ++++ ++++gl    
   mKIAA1580   101    HLEILQLSR-N-HI-RTIEIGaFnGLA    124  

LRR_1: domain 3 of 9, from 125 to 148: score 16.1, E = 0.85
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      nL +L+L + N +l+ ++p++++  l+   
   mKIAA1580   125    NLNTLELFD-N-RLT-TIPNGaFvYLS    148  

LRR_1: domain 4 of 9, from 149 to 172: score 17.0, E = 0.45
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L+eL L++ N +++ s+p+ +++  p   
   mKIAA1580   149    KLKELWLRN-N-PIE-SIPSYaFnRIP    172  

LRR_1: domain 5 of 9, from 173 to 197: score 9.8, E = 49
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L+ LdL+   ++ls  +++++++gl+   
   mKIAA1580   173    SLRRLDLGE-LKRLS-YISEGaFeGLS    197  

LRR_1: domain 6 of 9, from 198 to 219: score 8.4, E = 80
                   *->nLeeLdLsgCNpslsgslppsl.glp<-*
                      nL++L+L  C  +l +++p+ l  l    
   mKIAA1580   198    NLRYLNLAMC--NL-REIPN-LtPLI    219  

LRR_1: domain 7 of 9, from 220 to 243: score 19.1, E = 0.11
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L eLdLsg N +ls  + p++++gl    
   mKIAA1580   220    KLDELDLSG-N-HLS-AIRPGsFqGLM    243  

LRR_1: domain 8 of 9, from 244 to 267: score 5.3, E = 2.6e+02
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L++L +   + +++  ++ +++++l+   
   mKIAA1580   244    HLQKLWMIQ-S-QIQ-VIERNaFdNLQ    267  

LRR_1: domain 9 of 9, from 268 to 291: score 15.7, E = 1.1
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L e++L + N +l+  lp + +  l    
   mKIAA1580   268    SLVEINLAH-N-NLT-LLPHDlFtPLH    291  

ig: domain 1 of 1, from 368 to 428: score 34.4, E = 2.6e-06
                   *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq
                      G  + L C++   +++ ++v+W   ++++ ++  ++ ++  + s+ +
   mKIAA1580   368    GMAAELKCRA---STSLTSVSWITPNGtVMtHG-AYKVRIAVLSDGT 410  

                   tsLtitnvtpeDggtYtCvv<-*
                     L++tnvt +D+g YtC+v   
   mKIAA1580   411 --LNFTNVTVQDTGMYTCMV    428  

I-set: domain 1 of 1, from 354 to 444: score 52.8, E = 7.3e-12
                   *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKd.Gqplssvll
                      P+++ +p d++V+eG +a++ C+++ +   +VsW   +G  ++    
   mKIAA1580   354    PVIVEPPADLNVTEGMAAELKCRASTS-LTSVSWITPnGTVMTH--- 396  

                   ps...drfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasae
                    +  + r+ v  dg     tL + nv+  D G YtC ++Ns+G  +asa+
   mKIAA1580   397 -GaykVRIAVLSDG-----TLNFTNVTVQDTGMYTCMVSNSVGNTTASAT 440  

                   LtVq<-*
                   L+V+   
   mKIAA1580   441 LNVT    444  

V-set: domain 1 of 1, from 352 to 444: score 34.2, E = 2.9e-06
                   *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss
                        +v  epp+           + v eG  ++L+C  s     +    
   mKIAA1580   352    YAPVIVEPPA----------DLNVTEGMAAELKCRAS-----T---- 379  

                   gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn
                   + +sv+W                        +g+  +++ +k r+ + ++
   mKIAA1580   380 SLTSVSWIT---------------------PNGTVMTHGAYKVRIAVLSD 408  

                   pskgdfsLtIsnlqlsDsGtYyCa........gggtrLtVl<-*
                   ++     L+ +n+++ D+G+Y+C  +++ +++  + +L V+   
   mKIAA1580   409 GT-----LNFTNVTVQDTGMYTCMvsnsvgntTASATLNVT    444  

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