hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpf/mpf01039/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1575  ( 1724 res)   mpf01039

Scores for sequence family classification (score includes all domains):
Model      Description                                  Score    E-value  N 
--------   -----------                                  -----    ------- ---
Ank        Ankyrin repeat                                81.7    1.5e-20   3
Atrophin-1 Atrophin-1 family                           -676.3       0.99   1

Parsed for domains:
Model      Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------   ------- ----- -----    ----- -----      -----  -------
Atrophin-1   1/1     390  1330 ..     1  1064 []  -676.3     0.99
Ank          1/3    1431  1464 ..     1    33 []    18.3     0.19
Ank          2/3    1465  1497 ..     1    33 []    28.3  0.00017
Ank          3/3    1498  1530 ..     1    33 []    37.3  3.6e-07

Alignments of top-scoring domains:
Atrophin-1: domain 1 of 1, from 390 to 1330: score -676.3, E = 0.99
                   *->GkhsmrtrlyrGststllSGRKKqPasPdGraaavsv..........
                         +  t  +  sts l  G  K P   dG+  a s ++++++++ +
   mKIAA1575   390    -TKPYMTANSEFSTSRLSNG--KYPKALDGGDCAQSMpghtrkttvq 433  

                   dvrssGknsPs..aastiSnDsKAEAvKKsAKKVkeeaASglknTKRqRE
                   d + +G  sP+     t+  D        s K V  +a  g    K    
   mKIAA1575   434 DRKDGG--SPPllEKQTVTKDVTDKPLDLSSKVVDADASKGDHMKK---- 477  

                   KvAsDtEDtDRAtsKKtKtqEisrPtsPveGenlsSdsrsvNDEGssDPK
                    +A       RA s         +  + +  +n  S  rs          
   mKIAA1575   478 -MAPTVLVHSRAASGLVLSGSEIPKETLSPPGNGCSIYRSEI-------- 518  

                   DiDqDfrsvsPs...lPsPqdlrslsdaSAsqqgLqaQPlalqlPSga.A
                          s+ Ps+  +P P  ++  +  S s   L    l   +P   + 
   mKIAA1575   519 ------ISTAPSswvVPGPSPNEENNGKSLS---LKNKALDWAIPQQRsS 559  

                   saqstGGlPPGteklPT.laPsPsattlPPasSsAt..............
                   s + +     Gt+   T+   s s+   P   S+A++ + + ++++++++
   mKIAA1575   560 SCPRM----GGTDAVVTnVSGSVSSSGRPASASPAPnananadgtktsrs 605  

                   ...aqPmRFPysssSsvaaAAs.slissssslasPflaSqa....lPlyP
                   + +  P       + s+ +A ++ + ss    a P +   a++++lP   
   mKIAA1575   606 svdTTPSVIQHVGQPSSTPAKHgGSTSSKGAKANPEPSFKAsengLPPTS 655  

                   msaPPstsLsvSaQPPKytQPSLhsQavpsPHsLqtGPL.LQgPgPPqPy
                       P       a P  y+   L+  a+ +   +   PL+L g gP  P 
   mKIAA1575   656 IFLSPNEAFRSPAIP--YPRSYLPYAAPEG---IALSPLsLHGKGPVYPH 700  

                   GRLlanSsagqGPlgPStaAqstAHPPvstHHstiQlqasQsalQqQQqh
                     Ll+n s  +G l P ++       P   H s       Q al     h
   mKIAA1575   701 PVLLPNGSLFPGHLAPKPGL------PYGLHTSRPEFVTYQDALGLGMVH 744  

                   renslPPaPlAfPH.PLEGGssikahPyamiPsLGsLRPYPagqAHkhPP
                           P  +PH+P+E     k+     +        Y  +       
   mKIAA1575   745 --------PMLIPHtPIEITKEEKPERRSRSHER---ARYEDPTLRSRFS 783  

                   HLSqvSyfsanaNlPPvssalkslSSlStgsyPsaHPsPlQLgPQsaPlP
                    +   S     +  P     lk+ SS  +g            g  s  l 
   mKIAA1575   784 EMLEASSTKLHPEVPTD-KNLKPNSSWNQGKT----------GVKSDKLV 822  

                   fsPvqPtvlTsSasLstviatvASsPatyklasvPsqsPygkrafvPGay
                   +       l   a       t A  P  + +a   +q      a  P a 
   mKIAA1575   823 YVDL----LREEADTK----TDAGAPKAGLVAENVGQD---TEATKPSAD 861  

                   ktiTPPsykPGsPPsFR......TsTPPaYRGtSssaqPGtFKPgSaaVs
                   + i           s R++ ++ T     +     s+qP  F  g     
   mKIAA1575   862 PVIQQRREFI----SLReelgriTDFHESFTFKQASSQP-VFSLGKDSGA 906  

                   sGglvPaaPSgLPsLPPPPAAPAsGPPLsAvQIKeEaldEaEePESPvPP
                    G +          +  P    A G   +Av   +       + E P P 
   mKIAA1575   907 AGTNKENLGVQ---VATPFLETALGSEGPAVTFGK-------TQEDPKPF 946  

                   aRSPSPePkVVDvPSHASQSARFyKHLDRGyNSCARsDLYFvPLeGSKLA
                        P+   V +P               G       D   +    SKLA
   mKIAA1575   947 CVGGAPPNMDV-TPAYTKE----------GTDEAESNDGKVLKPKPSKLA 985  

                   KKRe.......dlvEKvkRE....AEQkAREEkEREkEkEkEkEREREkE
                   K+ +++ +  +d    v  E   +  Q  RE +   +   +  E E  kE
   mKIAA1575   986 KRIAnsagyvgDRFKCVTTElyadSSQLSREQRALQRAMMRFSELEM-KE 1034 

                   RElERavkkAsssAqEGRAPledPsLsGPvhmRP...sFEPPgsavAaVP
                   RE    + k s   +    P +   L G     P++   E    a+A   
   mKIAA1575  1035 REGSHPATKDSEVCKF--SPADWERLKGNQEKKPksvTLE---EAIAD-- 1077 

                   PYlGPDTPALRTLSEYARPHVMSPtNRNHPFYvPLnavDPGLLaYnvPaL
                             R   EY      S +N    F  P     P          
   mKIAA1575  1078 -----QNDSER--CEY------STGNKHDLFEAPEDKDLP---------- 1104 

                   YsvDPaiRERELREREiREREiRERdLRdRlKPGFEVKPsELdPLHgvtn
                                     E    ER                     +v  
   mKIAA1575  1105 -----------------VEKYFLERP--------------------PVSE 1117 

                   PGldhFaRHsaLalqPaPaGlHPFAsFHPsLnPLERERLALAAGPaLRPd
                   P              P   G     +  P L  L R R            
   mKIAA1575  1118 P--------------PSDQGVVDT-PHSPTLR-LDRKR------------ 1139 

                   MSYadRLAAERiHAE.RvAaLtsDPL.ARLQMlNVTPHHHQHSHIHSHLH
                         L     H E+ v  L  DPL+A    +    H     H    LH
   mKIAA1575  1140 -----KLSGDSTHTEtAVEELAEDPLkAKRRRISKGLHPKKQRHL---LH 1181 

                   LH....QQDalHaaSAsP.......VHPLvDP.Laa.GsHLaRiPYPaGT
                   L ++ +QQ  + aa   P+++++++V   v P+ +++G   +     +G 
   mKIAA1575  1182 LRerweQQ--VSAAESKPgrqsrkeVAQAVQPeVTSqGTNITEE--KPGR 1227 

                   LPNPLLgqPlHEnEvLRHqlFaaPYPRDLPa.alsaPM........SAAH
                         g      E L            LP  + s+PM++ ++++ S   
   mKIAA1575  1228 KKAEAKGNRGWSEESLK----SCDNEQGLPVlSGSPPMkslsstnaSGKK 1273 

                   QLQAMHAQSAELQRLAlEqQQWLHaHhhlHsvhLPaQED.........YY
                   Q Q          RL    QQ                ED +  ++ ++Y 
   mKIAA1575  1274 QTQPSCTPAS---RLPAK-QQKIKESQKTDVLCTGEDEDcqaasplqkYT 1319 

                   SrLKKEsDKqL<-*
                       K s K L   
   mKIAA1575  1320 DNIEKPSGKRL    1330 

Ank: domain 1 of 3, from 1431 to 1464: score 18.3, E = 0.19
                   *->dGfTPLHlAalrgnlevvklLls.qGAdlnaqdd<-*
                       G+T L  Aa+ g++evv + l+++ +d+n++d+   
   mKIAA1575  1431    AGETLLQRAARLGYEEVVLYCLEnKVCDVNHRDN    1464 

Ank: domain 2 of 3, from 1465 to 1497: score 28.3, E = 0.00017
                   *->dGfTPLHlAalrgnlevvklLlsqGAdlnaqdd<-*
                       G+ +LH A+ rg l++v+ Ll++GAd+n       
   mKIAA1575  1465    AGYCALHEACARGWLNIVRHLLEYGADVNCSAQ    1497 

Ank: domain 3 of 3, from 1498 to 1530: score 37.3, E = 3.6e-07
                   *->dGfTPLHlAalrgnlevvklLlsqGAdlnaqdd<-*
                      dG  PLH A+++++le+v+lLls+GAd+ + +    
   mKIAA1575  1498    DGTRPLHDAVENDHLEIVRLLLSYGADPTLATY    1530 

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