hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mpg/mpg00841/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1531  ( 1214 res)   mpg00841

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
LRR_1    Leucine Rich Repeat                             26.8    0.00052   3
ig       Immunoglobulin domain                           21.3      0.023   1
GPS      Latrophilin/CL-1-like GPS domain                19.0      0.013   1
HRM      Hormone receptor domain                         12.6      0.018   1
7tm_2    7 transmembrane receptor (Secretin family)     -62.0    7.9e-06   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
LRR_1      1/3      11    34 ..     1    25 []    18.8     0.13
LRR_1      2/3      35    58 ..     1    25 []    10.6       35
ig         1/1     139   208 ..     1    65 []    21.3    0.023
HRM        1/1     228   299 ..     1    76 []    12.6    0.018
LRR_1      3/3     482   508 ..     1    25 []     1.0  1.4e+03
GPS        1/1     585   634 ..     1    55 []    19.0    0.013
7tm_2      1/1     645   951 ..     1   296 []   -62.0  7.9e-06

Alignments of top-scoring domains:
LRR_1: domain 1 of 3, from 11 to 34: score 18.8, E = 0.13
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L+ LdLs+ N ++ g+l +++++glp   
   mKIAA1531    11    ELKRLDLSN-N-RI-GCLTSEtFqGLP    34   

LRR_1: domain 2 of 3, from 35 to 58: score 10.6, E = 35
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L  L++sg N   s sl+p+ ++ lp   
   mKIAA1531    35    RLLRLNISG-N-IYS-SLQPGvFdELP    58   

ig: domain 1 of 1, from 139 to 208: score 21.3, E = 0.023
                   *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenng...ds
                      G+++ ++Cs+s     d++++W++ng +++++++++++  ++  +d 
   mKIAA1531   139    GDRLPFQCSAS-YLGNDTRIHWYHNGApMEsDEQAGIVLAENlihDC 184  

                   tyqt.sLtitnvtpeDggtYtCvv<-*
                   t++t+ Lt++ +    +g++ C v   
   mKIAA1531   185 TFITsELTLSHIGVWASGEWECSV    208  

HRM: domain 1 of 1, from 228 to 299: score 12.6, E = 0.018
                   *->glgCpat....wDgivCWPrtpaGqlvvvpCPdy......fsGfnyd
                       ++Cpa++ +++ g   WPrt aG ++ ++C  y+ ++ ++sG  + 
   mKIAA1531   228    ASYCPAErvtnNRGDFRWPRTLAGITAYQSCLQYpftsvpLSGGAPG 274  

                   ttgedfgnayRnCtenGwwerhpsnwpwpnysaCtsney<-*
                   t+      a+R+C+  G+we       + +ys+C  +++   
   mKIAA1531   275 TR------ASRRCDRAGRWE-------PGDYSHC-LYTN    299  

LRR_1: domain 3 of 3, from 482 to 508: score 1.0, E = 1.4e+03
                   *->nLeeLdLsgCNpslsgs..lpps.l.glp<-*
                      +L + ++ + +  l  s  lpps ++ lp   
   mKIAA1531   482    SLSSFHIKN-SVALA-SiqLPPSlFsTLP    508  

GPS: domain 1 of 1, from 585 to 634: score 19.0, E = 0.013
                   *->tnpiCvfWdesslestgvWstdrGCevveenkpshttCsCnHLTtFA
                       +p  ++W+ +     g+Ws+ +GC++ + +  +  +  C+HL++ A
   mKIAA1531   585    ADPMAAWWNQDG---PGGWSS-EGCRLRYSQP-NVSSLYCQHLGNVA 626  

                   vlmdvppn<-*
                   vlm +++    
   mKIAA1531   627 VLMELNAF    634  

7tm_2: domain 1 of 1, from 645 to 951: score -62.0, E = 7.9e-06
                   *->lllLkviytVGyslSSLvaLllAiaifll.fRkLhCtRnyIHlNLfa
                      l+ + +  t   +l  L +L  +i+++ l+  ++h  R   H+ L +
   mKIAA1531   645    LHPVVYPCT---ALL-LLCLFSTIITYILnHSSIHVSRKGWHMLLNL 687  

                   sfiLral.sfLikdavlfnsvglseadqlsweeslhcsasagkitmivvV
                   +f ++ +++++++ + l n ++                            
   mKIAA1531   688 CFHMAMTsAVFVGGVTLTNYQMV--------------------------- 710  

                   gCkvvavflhYfflaNFfWmLVEGlYLhtllvvt........vevffser
                    C +v + lhY  l++  Wm V +  Lh  l  + + ++ ++ e  ++ +
   mKIAA1531   711 -CQAVGITLHYSSLSSLLWMGVKARVLHKEL--SwrappleeGEAAPPGP 757  

                   krfwwYlliGWGvPavfvgiwaivrpdkwagygnegCCWlsnedngyfwW
                   + +++++li  G+P+++ gi a+v   +  + ++  +CWl  +   + + 
   mKIAA1531   758 RPMLRFYLIAGGIPLIICGITAAVNIHN--YRDHSPYCWLVWR---PSLG 802  

                   iikGPvllvIlvNfilFinilriLvqKlridkslspqmgetdqyrk....
                    ++ Pv+l++ +  i F++    L ++       ++   +++ +  ++++
   mKIAA1531   803 AFYIPVALILPITWIYFLCAGLHLRSHVA-----QNPKQGNRISLEpgee 847  

                   ................................................kr
                    +++++ ++++   +++++   + + + +++ +++++++  +++ + +  
   mKIAA1531   848 lrgstrlrssgvllndsgsllatvsagvgtpappedgdgvyspgvqlgAL 897  

                   lakstLlLlPLLGitwvlflfapeddsqGvssivflylfliLnSfQGffV
                   ++  +L L       w  +++a+  +     ++v   l  +  S  G+fV
   mKIAA1531   898 MTTHFLYLAM-----WACGALAVSQRW--LPRVVCSCLYGVAASALGLFV 940  

                   avlYCFlNgEV<-*
                   ++ +C  +++V   
   mKIAA1531   941 FTHHCARRRDV    951  

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