hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj58296/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1459  ( 855 res)   mfj58296

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
TyrKc    Tyrosine kinase, catalytic domain              433.2   1.3e-125   1
S_TKc    Serine/Threonine protein kinases, catalytic    144.9    8.4e-39   1
FN3      Fibronectin type 3 domain                       91.5    9.8e-23   2
SAM      Sterile alpha motif.                            78.6    7.5e-19   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
FN3        1/2     179   269 ..     1    69 []    35.2  8.8e-06
FN3        2/2     290   371 ..     1    69 []    56.4  3.8e-12
TyrKc      1/1     485   742 ..     1   280 []   433.2 1.3e-125
S_TKc      1/1     485   746 ..     1   231 []   144.9  8.4e-39
SAM        1/1     777   844 ..     1    67 []    78.6  7.5e-19

Alignments of top-scoring domains:
FN3: domain 1 of 2, from 179 to 269: score 35.2, E = 8.8e-06
                   *->PgpPsnptelrvtdvtststsdltsvtlsWepP.......ivgYr..
                      P++P n   l  + v+ t      svtl+W pP ++++ + ++Y  +
   mKIAA1459   179    PSAPVN---LISS-VNGT------SVTLEWAPPldpggrsDITYNav 215  

                   ...............................ytltgLkPgaepwteYefr
                    ++ ++  +  +  +++++ ++++++  + +  + +L ++     +Y+f+
   mKIAA1459   216 crrcpwalshceacgsgtrfvpqqtslaqasLLVANLLAH----MNYSFW 261  

                   VrAvngndaGeg<-*
                   + Av    +G +   
   mKIAA1459   262 IEAV----NGVS    269  

FN3: domain 2 of 2, from 290 to 371: score 56.4, E = 3.8e-12
                   *->PgpPsnptelrvtdvtststsdltsvtlsWepP......ivgYr...
                      P+ +     +r +  + t      sv+l W++P+ +++ i++Y+ + 
   mKIAA1459   290    PSQVVV---IRQERAGQT------SVSLLWQEPeqpngiILEYEiky 327  

                   ...................ytltgLkPgaepwteYefrVrAvngndaGeg
                    +++++ ++ ++ + +++++t++gLkPg    t+Y+f+VrA+++  aG g
   mKIAA1459   328 yekdkemqsystlkavttrATVSGLKPG----TRYVFQVRARTS--AGCG 371  

                   <-*
                      
   mKIAA1459     -     -    

TyrKc: domain 1 of 1, from 485 to 742: score 433.2, E = 1.3e-125
                   *->ltlgkkLGeGaFGeVykGtlk......ieVAVKtLkeda....keeF
                      ++ +k++G+G+ GeV+ G+l  +++++++VA+K Lk++ +++++++F
   mKIAA1459   485    IHIEKIIGSGESGEVCYGRLQvpgqrdVPVAIKALKAGYterqRQDF 531  

                   lrEakiMkklGgkHpNiVkLlGvcteegrrFmevePlmivmEymegGdLl
                   l+Ea iM ++  +HpNi++L Gv+t +          miv+Eyme+G+L+
   mKIAA1459   532 LSEAAIMGQF--DHPNIIRLEGVVTRG-------RLAMIVTEYMENGSLD 572  

                   dyLrknrpklslsdLlsfAlQIAkGMeYLesknfvHRDLAARNcLvgenk
                    +Lr + ++++  +L+ +   + +GM+YL++ +++HRDLAARN+Lv+ ++
   mKIAA1459   573 AFLRTHDGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGRL 622  

                   vvKIsDFGLsRdlyddDkkGeskdyYrkkggkggktllPirWmAPEslkd
                   v+K+sDFGLsR+l+dd     +  y ++    ggk  +PirW+APE++ +
   mKIAA1459   623 VCKVSDFGLSRALEDD----PEAAYTTA----GGK--IPIRWTAPEAIAF 662  

                   gkFtskSDVWSFGVlLWEiftlGeqPYpgeiqqfmsneevleylkkGyRl
                   ++F+s+SDVWSFGV++WE++ +Ge PY++     m+n++v+  +++GyRl
   mKIAA1459   663 RTFSSASDVWSFGVVMWEVLAYGERPYWN-----MTNQDVISSVEEGYRL 707  

                   pkPendlpiSsvtCPdelYdlMlqCWaedPedRPtFselverl<-*
                   p P          CP +l++lMl+CW+ d ++RP+F+ +v+ l   
   mKIAA1459   708 PAPMG--------CPRALHQLMLDCWHKDRAQRPRFAHVVSVL    742  

S_TKc: domain 1 of 1, from 485 to 746: score 144.9, E = 8.4e-39
                   *->YellkklGkGaFGkVylardkk...tgrlvAiKvik........eri
                       ++ k++G+G  G+V+ +r   +++ +  vAiK +k + ++++++++
   mKIAA1459   485    IHIEKIIGSGESGEVCYGRLQVpgqRDVPVAIKALKagyterqrQDF 531  

                   lrEikiLkk.dHPNIVkLydvfed.dklylVmEyceGdlGdLfdllkkrg
                   l+E +i+ + dHPNI++L +v   +    +V+Ey+e+  G+L  +l+ + 
   mKIAA1459   532 LSEAAIMGQfDHPNIIRLEGVVTRgRLAMIVTEYMEN--GSLDAFLRTHD 579  

                   rrglrkvlsE.earfyfrQilsaLeYLHsqgIiHRDLKPeNiLLds..hv
                   ++     ++  +   ++r +  ++ YL ++g iHRDL   N+L+d + + 
   mKIAA1459   580 GQ-----FTIvQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDGrlVC 624  

                   KlaDFGlArql..........ttfvGTpeYmAPEvl...gYgkpavDiWS
                   K++DFGl+r l+++++   ++        + APE +  + ++  a+D+WS
   mKIAA1459   625 KVSDFGLSRALeddpeaayttAGGKIPIRWTAPEAIafrTFSS-ASDVWS 673  

                   lGcilyEllt.GkpPFp...qldlifkkig..........SpeakdLikk
                   +G++++E l+ G+ P+++ +++d+i  +  +++ + + + ++ + +L+  
   mKIAA1459   674 FGVVMWEVLAyGERPYWnmtNQDVISSVEEgyrlpapmgcPRALHQLMLD 723  

                   lLvkdPekRlta.eaLedeldikaHPff<-*
                   +++kd ++R+    +        ++  +   
   mKIAA1459   724 CWHKDRAQRPRFaHVVS-----VLDALV    746  

SAM: domain 1 of 1, from 777 to 844: score 78.6, E = 7.5e-19
                   *->vs.wspesVaeWLesigleqYadnFrkngidgeelllltseedLkel
                       s++   +V++WL+si++++Y+d+F++ g+++  ++l+++ +d   l
   mKIAA1459   777    GSgNGDLTVGDWLDSIRMGRYRDHFAAGGYSSLGMVLRMNAQDVRAL 823  

                   GitllGhRkkIlsaiqklkeq<-*
                   Gitl Gh+kkIl +iq++++q   
   mKIAA1459   824 GITLMGHQKKILGSIQTMRAQ    844  

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