hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mfj/mfj58296/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1459 ( 855 res) mfj58296 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase_Tyr Protein tyrosine kinase 470.3 1.6e-137 1 Pkinase Protein kinase domain 140.9 2.2e-38 1 fn3 Fibronectin type III domain 118.9 9.6e-32 2 SAM_1 SAM domain (Sterile alpha motif) 102.0 1.2e-26 1 SAM_2 SAM domain (Sterile alpha motif) 64.9 1.7e-15 1 GCC2_GCC3 GCC2 and GCC3 14.2 0.02 1 Ephrin_lbd Ephrin receptor ligand binding domain -32.3 2.9e-06 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Ephrin_lbd 1/1 1 54 [. 1 177 [] -32.3 2.9e-06 GCC2_GCC3 1/1 115 157 .. 1 50 [] 14.2 0.02 fn3 1/2 179 275 .. 1 84 [] 38.7 1.3e-07 fn3 2/2 287 374 .. 1 84 [] 80.2 4.2e-20 Pkinase 1/1 485 742 .. 1 287 [] 140.9 2.2e-38 Pkinase_Tyr 1/1 485 742 .. 1 272 [] 470.3 1.6e-137 SAM_1 1/1 778 842 .. 1 66 [] 102.0 1.2e-26 SAM_2 1/1 778 844 .. 1 72 [] 64.9 1.7e-15 Alignments of top-scoring domains: Ephrin_lbd: domain 1 of 1, from 1 to 54: score -32.3, E = 2.9e-06 *->EvtLLDtktatgELGWltyPpdGWeEvsglDEnnrpIrTYQVCnVme mKIAA1459 - ----------------------------------------------- - pnQnNWLRTnwIeRrgAqRvyveLkFTvRDCnSlPgvlGtCKETFNLYYy mKIAA1459 - -------------------------------------------------- - ESDedvgtalpawrenqyiKvDTIAADESFtqvDlgdrvlKLNtEvRsvG DESFt +Dlg r+lKLNtEvR vG mKIAA1459 1 --------------------------DESFTGADLGVRRLKLNTEVRGVG 24 PLsKkGFYLAFQDvGACiALvSVRVFYKKC<-* PLsK+GFYLAFQD+GAC+A++S+R++YKKC mKIAA1459 25 PLSKRGFYLAFQDIGACLAILSLRIYYKKC 54 GCC2_GCC3: domain 1 of 1, from 115 to 157: score 14.2, E = 0.02 *->GtysnsgtkpCepCPiGtYQpeegqdsCipCPpgknttTdktGatse G+ + C +C+ G+Y++ g + C +CPp+ + ++ + mKIAA1459 115 GYEERRDA--CMACELGFYKSAPGDQLCARCPPH--S---HSATPAA 154 sdC<-* + C mKIAA1459 155 QTC 157 fn3: domain 1 of 2, from 179 to 275: score 38.7, E = 1.3e-07 *->PsaPtnltvtdvtstsltlsWsppt..gngpitgYevtyR...qpkn PsaP nl +++v+ ts+tl+W pp ++g++ Y+ +R+ ++ + mKIAA1459 179 PSAPVNL-ISSVNGTSVTLEWAPPLdpGGRSDITYNAVCRrcpWALS 224 gge.......wneltvpgtttsytltgLkPgteYevrVqAvnggG..Gpe + e +++++ + ++ + + s + +L ++++Y++++ Avng+ + +pe mKIAA1459 225 HCEacgsgtrFVPQQTSLAQASLLVANLLAHMNYSFWIEAVNGVSnlSPE 274 S<-* mKIAA1459 275 P 275 fn3: domain 2 of 2, from 287 to 374: score 80.2, E = 4.2e-20 *->PsaPtnltvtdv...tstsltlsWsppt.gngpitgYevtyRqpkng aP++++v+ +++ + ts++l W+ p+++ng i Ye++y ++k++ mKIAA1459 287 QAAPSQVVVIRQeraGQTSVSLLWQEPEqPNGIILEYEIKY-YEKDK 332 gewnelt.vpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* + +++++++ +tt++t++gLkPgt+Y+++V+A++ +G G++S mKIAA1459 333 E-MQSYStLKAVTTRATVSGLKPGTRYVFQVRARTSAGcGRFS 374 Pkinase: domain 1 of 1, from 485 to 742: score 140.9, E = 2.2e-38 *->yelleklGsGsfGtVykakhkgtgk...iVAvKiikkrkekskkdkt +++++++GsG +G+V+ ++ + g+++ VA+K +k ++ +++ mKIAA1459 485 IHIEKIIGSGESGEVCYGRLQVPGQrdvPVAIKALKAGYTER--QRQ 529 arrrsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdy ++++ E++i+ ++HpNI+rl +v+++++ +V+Ey+e+G +L ++ mKIAA1459 530 DFLS-EAAIMGQFDHPNIIRLEGVVTRGRLAMIVTEYMENG----SLDAF 574 lsetrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILlde l+ +g + + ++ +++ + g+ YL + g iHRDL N+L+d mKIAA1459 575 LR--THDGQF--TIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVDG 620 ngvvdaflKiaDFGlAkklst.sss.lttfvGT...pwYmAPEvllggng + v+ K++DFGl++ l ++ + ++t +G + ++++ APE + + mKIAA1459 621 RLVC----KVSDFGLSRAL-EdDPEaAYTTAGGkipIRWTAPEAIA-FRT 664 ygtkvDvWSlGvilyellt..GkpPFsgev.q.ds.ldqlqlirkilgpp ++++DvWS+Gv+++e+l + +p + +++ +s++ + +++ +g+p mKIAA1459 665 FSSASDVWSFGVVMWEVLAygERPYWNMTNqDvISsVEEGYRLPAPMGCP 714 lefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqH +++ +L+ +c++kD ++R+ +++++ mKIAA1459 715 -----------------------RALHQLMLDCWHKDRAQRPRFAHVVSV 741 Pwf<-* + mKIAA1459 742 --L 742 Pkinase_Tyr: domain 1 of 1, from 485 to 742: score 470.3, E = 1.6e-137 *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtLkeigasseeie +++ k +G+G+ GeV+ G+l +++ +++VA+K Lk g+++++ mKIAA1459 485 IHIEKIIGSGESGEVCYGRLQ-VPGQRDVPVAIKALKA-GYTERQ-- 527 redFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGdL r+dFl+EA+iM ++ dHpNi+rL Gv+t+ g+ +iVtEyme+G+L mKIAA1459 528 RQDFLSEAAIMGQF-DHPNIIRLEGVVTR-GRL----AMIVTEYMENGSL 571 ldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVs + fLr+h ++++t+ +L+++ + + +GM YL++ +++HRDLAARN+LV+ mKIAA1459 572 DAFLRTH--DGQFTIVQLVGMLRGVGAGMRYLSDLGYIHRDLAARNVLVD 619 enlvVKIsDFGLaRdiynddyY.vrkkgggklPvkWmAPEslkygkFtsk lv+K+sDFGL+R++ +dd +++ ggk+P++W+APE+++++ F+s+ mKIAA1459 620 GRLVCKVSDFGLSRAL-EDDPEaAYTTAGGKIPIRWTAPEAIAFRTFSSA 668 SDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPde SDVWSFGV++WE++ +Ge P Y++m+n++v+ + e+GyRLp+P++CP mKIAA1459 669 SDVWSFGVVMWEVLAYGERP-YWNMTNQDVISSV-EEGYRLPAPMGCPRA 716 lYdlMlqCWaedPedRPtFselverL<-* l++lMl CW++d ++RP+F+ +v+ L mKIAA1459 717 LHQLMLDCWHKDRAQRPRFAHVVSVL 742 SAM_1: domain 1 of 1, from 778 to 842: score 102.0, E = 1.2e-26 *->dgwsvesVgeWLesigllgqYidnFlaagyidgdtllqlteeDLedl +g+ + +Vg+WL+si++ g+Y+d+F+a gy+++ ++l+++++D ++l mKIAA1459 778 SGNGDLTVGDWLDSIRM-GRYRDHFAAGGYSSLGMVLRMNAQDVRAL 823 GvtllGHrkkIlssIqgLk<-* G+tl+GH+kkIl sIq+++ mKIAA1459 824 GITLMGHQKKILGSIQTMR 842 SAM_2: domain 1 of 1, from 778 to 844: score 64.9, E = 1.7e-15 *->veswslesvaeWLesiglegqYkdnFsdqgitglellllrlteedLa + +l +v++WL+si++ g+Y+d F + g+++l ++ lr++++d mKIAA1459 778 SGNGDL-TVGDWLDSIRM-GRYRDHFAAGGYSSLGMV-LRMNAQDV- 820 klalGitsvghRkkilskiqelkqq<-* alGit+ gh+kkil +iq ++ q mKIAA1459 821 R-ALGITLMGHQKKILGSIQTMRAQ 844 //