hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mib/mib23074/w3open/interpro/cnk_1/seq.in
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query:  mKIAA1415  ( 1665 res)   mib23074

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
DEP      Domain found in Dishevelled, Egl-10, and Ple   199.3    3.6e-55   2
RhoGEF   Guanine nucleotide exchange factor for Rho/R   188.7    5.3e-52   1
PH       Pleckstrin homology domain.                     51.3    1.3e-10   1
PDZ      Domain present in PSD-95, Dlg, and ZO-1/2.      26.7     0.0032   2

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RhoGEF     1/1      63   249 ..     1   211 []   188.7  5.3e-52
PH         1/1     282   404 ..     1    82 []    51.3  1.3e-10
DEP        1/2     433   506 ..     1    90 []   104.2  1.5e-26
DEP        2/2     534   607 ..     1    90 []    95.3    7e-24
PDZ        1/2     643   716 ..     1    80 []    13.8     0.75
PDZ        2/2     727   798 ..     1    80 []    12.9     0.94

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 63 to 249: score 188.7, E = 5.3e-52
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      vl+E+l TEr+YV +L+ l+  fl+++++ +  s  + l+++ vk l
   mKIAA1415    63    VLNEILGTERDYVGTLRFLQSAFLQRIRQNVADSVEKGLTEENVKVL 109  

                   FgpNieeiyefHrrFLdeLeerveewllskdlKsernsviedsgerigdv
                   F+ Nie+i+e+H++FL++Le+++   +              +s++++g+v
   mKIAA1415   110 FS-NIEDILEVHKDFLAALEYCLHPEP--------------QSQHELGNV 144  

                   FlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeiesk
                   Flk+   ++ f +Y eYcsnh++al+ll +L   +k pa+++fl  +++ 
   mKIAA1415   145 FLKF---KDKFCVYEEYCSNHEKALRLLVEL---NKVPAVRAFLLSCMLL 188  

                   pncrsksea.rltLeslLikPvQRltkYpLLLkellkhtppdhedredLk
                      r   + ++ +Le +L+ P+QR++kYpLLLkel k tp  h+d+  ++
   mKIAA1415   189 -GGR---KTtDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHTAVQ 234  

                   kAleaikelasqvNe<-*
                    Al+a+k+++s +Ne   
   mKIAA1415   235 SALQAMKTVCSNINE    249  

PH: domain 1 of 1, from 282 to 404: score 51.3, E = 1.3e-10
                   *->vikeGwLlkksk.swkkryfvLfngvLlyyksk..............
                      ++++G Llk s ++ ++r f+Lf++ L+y+k k++ +++++++++++
   mKIAA1415   282    LLLQGNLLKISAgNIQERAFFLFDNLLVYCKRKsrvtgskkstkrtk 328  

                   .......kpkgsipLsgcsvre.p...............cFeivt.dr..
                   + +++    +g+i+ + ++v+  +++  + ++++    ++++i+++ +++
   mKIAA1415   329 singslyIFRGRINTEVMEVENvEdgtadyhsngytvtnGWKIHNtAKnk 378  

                   tlllqAeseeereeWvealqsaiaka<-*
                    ++  A+++ee+++W++al +  ++    
   mKIAA1415   379 WFVCMAKTAEEKQKWLDALIREREQR    404  

DEP: domain 1 of 2, from 433 to 506: score 104.2, E = 1.5e-26
                   *->pesglklddrkyflktypncFtGselVdWLldnlegqsnngptkttf
                       +++l++d r+++l+t+p+cF+G+e+V WLl+++e            
   mKIAA1415   433    KKVNLIKD-RRRKLSTVPKCFLGNEFVAWLLEIGE------------ 466  

                   iidreeAvhlgqaLlkeGlihhvndpnkhtFkdsknalYrFtd<-*
                   i++ ee+v+lgqaLl++G ihhv+  +kh+Fk++ +++YrF+    
   mKIAA1415   467 ISKTEEGVNLGQALLENGIIHHVS--DKHQFKNE-QVMYRFRY    506  

DEP: domain 2 of 2, from 534 to 607: score 95.3, E = 7e-24
                   *->pesglklddrkyflktypncFtGselVdWLldnlegqsnngptkttf
                      ++ ++++d r+y+lkty++++ Gs lVdWLl +++            
   mKIAA1415   534    LYAPVIKD-RDYHLKTYKSVVPGSKLVDWLLAQGD------------ 567  

                   iidreeAvhlgqaLlkeGlihhvndpnkhtFkdsknalYrFtd<-*
                   +++reeAv+lg  L+++G++hhv+   k  Fkd+ ++++rF+    
   mKIAA1415   568 CQTREEAVALGVGLCNNGFMHHVL--EKSEFKDE-SQYFRFHA    607  

PDZ: domain 1 of 2, from 643 to 716: score 13.8, E = 0.75
                   *->gglGfsivg...gifvssvvpGspAakaGrkslglLkvGDvIleVNG
                        +Gf + ++++ ++v+sv++Gs A+ aG      L++G +I ++N 
   mKIAA1415   643    DDYGFDLEEknkAVVVKSVQRGSLAEMAG------LQAGRKIYSINE 683  

                   etsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                      v   +  e+  +l +   ++  ++++L+v  +    
   mKIAA1415   684 -DLVFLRPFSEVETILNQFFCSR--RPLRLLVATKA    716  

PDZ: domain 2 of 2, from 727 to 798: score 12.9, E = 0.94
                   *->gglGfsivg..gifvssvvpGspAakaGrkslglLkvGDvIleVNGe
                      + l f+i+g+ +  v  v +Gs A  aG      L++G  Il+VNG 
   mKIAA1415   727    EALSFQIRGtaPPCVFAVGRGSEAVAAG------LCAGQCILKVNG- 766  

                   tsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   tsv +   +e+++  ++ ++    ++  L +       
   mKIAA1415   767 TSVANDGALEVLEHFQAFRN---HREEALGLYQWV    798  

//