hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mib/mib23074/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1415 ( 1665 res) mib23074 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- RhoGEF RhoGEF domain 154.5 1.9e-42 1 DEP Domain found in Dishevelled, Egl-10, and Ple 130.1 4.2e-35 2 PH PH domain 39.1 9.8e-08 1 PDZ PDZ domain (Also known as DHR or GLGF) 6.9 0.38 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- RhoGEF 1/1 63 249 .. 1 207 [] 154.5 1.9e-42 PH 1/1 282 402 .. 1 92 [] 39.1 9.8e-08 DEP 1/2 431 504 .. 1 80 [] 70.5 3.6e-17 DEP 2/2 533 605 .. 1 80 [] 59.6 6.6e-14 PDZ 1/1 635 713 .. 1 82 [] 6.9 0.38 Alignments of top-scoring domains: RhoGEF: domain 1 of 1, from 63 to 249: score 154.5, E = 1.9e-42 *->vlkElleTEkkYvrdLeildnvymkpLreaaiss.kpvltpddieti vl+E+l TE+ Yv +L+ l+ ++++ r+ + s + lt + ++ + mKIAA1415 63 VLNEILGTERDYVGTLRFLQSAFLQRIRQNVADSvEKGLTEENVKVL 109 FsNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlkl FsNiedi+e+h++FL +Le +++ + +s+ lG +Flk+ mKIAA1415 110 FSNIEDILEVHKDFLA-ALEYCLHPE----------PQSQHELGNVFLKF 148 kepflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAk k+ f vY+eYcsn++ A ll l ++ ++F + ++ + t+ mKIAA1415 149 KDKFC-VYEEYCSNHEKALRLLVELNKVPAVRAFLLSCMLLGGRKTTD-- 195 ddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkkald L+ +Ll P+qRi++YpLLLkeL k tp +pd+ + al+ mKIAA1415 196 -----IPLEGYLLSPIQRICKYPLLLKELAKRTPG--KHPDHTAVQSALQ 238 llqdlaksiNe<-* +++++ + iNe mKIAA1415 239 AMKTVCSNINE 249 PH: domain 1 of 1, from 282 to 402: score 39.1, E = 9.8e-08 *->vikeGwLlkkggkkswkkRyfvLfndvLlyykdkk............ + +G Llk + ++ ++R f+Lf++ L+y+k k++ ++++++++++ mKIAA1415 282 LLLQGNLLKIS-AGNIQERAFFLFDNLLVYCKRKSrvtgskkstkrt 327 .......kkpkgsipLsgiqvekvpdn.........krkncFeirt.dr. ++ +++ + +g i+ + ++ve v+d++ + ++++ n+++i+++ ++ mKIAA1415 328 ksingslYIFRGRINTEVMEVENVEDGtadyhsngyTVTNGWKIHNtAKn 377 etlllqaeseeerkeWvkaiqsair<-* + ++ +a+++ee+++W++a+ ++ + mKIAA1415 378 KWFVCMAKTAEEKQKWLDALIRERE 402 DEP: domain 1 of 2, from 431 to 504: score 70.5, E = 3.6e-17 *->pesgvklk.drkwlkkvipncFtGselVdWLmdnlsgiidrkeAlhl +++v l +dr+ +++++p+cF+G+e+V WL+++++ i +e+++l mKIAA1415 431 MSKKVNLIkDRRRKLSTVPKCFLGNEFVAWLLEIGE-ISKTEEGVNL 476 aqlLlkeGyirhvgdhltgkndhtFldkqtyYrf<-* +q Ll+ G i+hv +++h+F q Yrf mKIAA1415 477 GQALLENGIIHHV------SDKHQFKNEQVMYRF 504 DEP: domain 2 of 2, from 533 to 605: score 59.6, E = 6.6e-14 *->pesgvklkdrkwlkkvipncFtGselVdWLmdnlsgiidrkeAlhla + +kdr +++k+++ + Gs lVdWL++ ++ ++r+eA+ l+ mKIAA1415 533 SLYAPVIKDRDYHLKTYKSVVPGSKLVDWLLAQGD-CQTREEAVALG 578 qlLlkeGyirhvgdhltgkndhtFldkqtyYrf<-* L++ G+++hv + F d + y+rf mKIAA1415 579 VGLCNNGFMHHV------LEKSEFKDESQYFRF 605 PDZ: domain 1 of 1, from 635 to 713: score 6.9, E = 0.38 *->evtlekevkrgglGfsikggsdkgivvsevlpGsgaAeagGrLkeGD + +++ + Gf + + ++ +vv++v++G + Ae +G L++G mKIAA1415 635 RLLIPP--QEDDYGFDLEEKNK-AVVVKSVQRG-SLAEMAG-LQAGR 676 qIlsvNG..qdvenlsheravlalkgsggsevtLtil<-* +I s+N + + ++ +s+ + +l + ++ ++++L+++ mKIAA1415 677 KIYSINEdlVFLRPFSEVETILNQFFCSRRPLRLLVA 713 //