hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mid/mid17020/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1369  ( 635 res)   mid17020

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
S_TKc    Serine/Threonine protein kinases, catalytic    145.2    6.7e-39   1
TyrKc    Tyrosine kinase, catalytic domain              -44.7    2.3e-08   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
S_TKc      1/1     183   596 ..     1   231 []   145.2  6.7e-39
TyrKc      1/1     183   596 ..     1   280 []   -44.7  2.3e-08

Alignments of top-scoring domains:
S_TKc: domain 1 of 1, from 183 to 596: score 145.2, E = 6.7e-39
                   *->YellkklGkGaFGkVylardkktgrlvAiKvik..............
                      +e l +lGkG++G+Vy++r+k +g+++AiK+i  ++ ++++  +  +
   mKIAA1369   183    FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILiksatktdcmkvlr 229  

                   ..................................................
                   + +   + ++++  + ++   ++ +  +++++ + + ++ +  +++++++
   mKIAA1369   230 evkvlaglqhpnivgyhtawiehvhvvqpqdrvpiqlpslevlseqegdr 279  

                   ..................................................
                   ++++ ++++++++    + +++++++ ++++ ++++++  + + +   ++
   mKIAA1369   280 dqggvkdnessssivfaeltpekekpfgesevknennnlvsytanlvvrn 329  

                   ...............................erilrEikiLkk..dHPNI
                   +++++++ + ++++ ++ + ++  +++ + + + + E +  + ++  +  
   mKIAA1369   330 ssesessielqedgltdlsvrpvvrhqlplgHSSELEGNFTSTdeSSEGN 379  

                   VkLydvfed...dklylVmEyceGdlGdLfdllkkrgrrglrk.......
                    +L++  e + +  l++ m +ce    +L d + +r++r + + ++   +
   mKIAA1369   380 LNLLGQTEVryhLMLHIQMQLCEL---SLWDWITERNKRSREYvdeaacp 426  

                   vlsE.earfyfrQilsaLeYLHsqgIiHRDLKPeNiLLds...hvKlaDF
                   +   ++a ++f+++++++ Y+H++gI+HRDLKP Ni+L  ++++vK++DF
   mKIAA1369   427 YVMAsVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGpdqQVKIGDF 476  

                   GlArql..................ttfvGTpeYmAPEvl...gYgkpavD
                   GlA+    ++ + +++++++++++t+ vGT  Y +PE l++++Y+  ++D
   mKIAA1369   477 GLACADiiqnadwtnrngkgtrthTSRVGTCLYASPEQLegsQYDA-KSD 525  

                   iWSlGcilyElltGkpPFp.qldlifkkig..............Speakd
                   ++SlG+il El+    PF +++++   + g ++++ +++ +++ + +ak 
   mKIAA1369   526 MYSLGVILLELFQ---PFGtEMERATVLTGvrtgripeslskrcPVQAK- 571  

                   LikklLvkdPekRlta.eaLedeldikaHPff<-*
                    i+ l  ++ ++R++a ++L+        + f   
   mKIAA1369   572 YIQLLTGRNVSQRPSAlQLLQ-------SELF    596  

TyrKc: domain 1 of 1, from 183 to 596: score -44.7, E = 2.3e-08
                   *->ltlgkkLGeGaFGeVykGtlk........ieVAVKtLkedakeeFlr
                       + + +LG G +G+Vyk + k ++++    +  +K+  +   +  lr
   mKIAA1369   183    FEELAILGKGGYGRVYKVRNKldgqhyaiKKILIKSATKTDCMKVLR 229  

                   EakiMkklGgkHpNiVkLlGvcteegrrFmevePlmivmEymegGdLldy
                   E k++  l  +HpNiV  + + +         e + +v         +d+
   mKIAA1369   230 EVKVLAGL--QHPNIVGYHTAWI---------EHVHVVQP-------QDR 261  

                   Lrknrpk...........................................
                        p  +  +++++++++++ ++++++++    + +++++++ ++++ 
   mKIAA1369   262 VPIQLPSlevlseqegdrdqggvkdnessssivfaeltpekekpfgesev 311  

                   ..................................................
                   ++++++  + + +   +++++++++ + ++++ ++ + ++  +++ + ++
   mKIAA1369   312 knennnlvsytanlvvrnssesessielqedgltdlsvrpvvrhqlplgh 361  

                   ..................................................
                   +++ +++ ++++++++++ +  ++++ + +   + + +  + +  +  ++
   mKIAA1369   362 sselegnftstdessegnlnllgqtevryhlmlhiqmqlcelslwdwite 411  

                   ....................lslsdLlsfAlQIAkGMeYLesknfvHRDL
                   +++++++  ++   +    ++ ++ + +      +G  Y++ +++vHRDL
   mKIAA1369   412 rnkrsreyvdeaacpyvmasVATKIFQELV----EGVFYIHNMGIVHRDL 457  

                   AARNcLvgenk.vvKIsDFGLsRd..lyddDkkGeskdyYrkkggkggkt
                     RN+ ++ + ++vKI+DFGL+ ++ + + D++  +++  r+ +   ++ 
   mKIAA1369   458 KPRNIFLHGPDqQVKIGDFGLACAdiIQNADWTNRNGKGTRTHT---SR- 503  

                   llPirWmAPEslkdgkFtskSDVWSFGVlLWEiftlGeqPYpgeiqqfms
                   +      +PE l  + +  kSD +S GV L E+f    qP   e    m+
   mKIAA1369   504 VGTCLYASPEQLEGSQYDAKSDMYSLGVILLELF----QPFGTE----ME 545  

                   neevleylkkGyRlpkPendlpiSsvtCPdelYdlMlqCWaedPedRPtF
                    + vl  +++G+ ++     +p       ++  +l +    ++ ++RP+ 
   mKIAA1369   546 RATVLTGVRTGRIPESLSKRCP-----VQAKYIQLLTG---RNVSQRPSA 587  

                   sel..verl<-*
                    +l + e++   
   mKIAA1369   588 LQLlqSELF    596  

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