hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mid/mid17020/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1369  ( 635 res)   mid17020

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Pkinase     Protein kinase domain                       163.7      3e-45   1
Pkinase_Tyr Protein tyrosine kinase                     -37.3    1.5e-09   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
Pkinase_Tyr   1/1     183   595 ..     1   272 []   -37.3  1.5e-09
Pkinase       1/1     183   596 ..     1   287 []   163.7    3e-45

Alignments of top-scoring domains:
Pkinase_Tyr: domain 1 of 1, from 183 to 595: score -37.3, E = 1.5e-09
                   *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtL.keigasseei
                      ++ +  LG+G +G+Vyk + k     ++++ A+K++  + +a+  ++
   mKIAA1369   183    FEELAILGKGGYGRVYKVRNK----LDGQHYAIKKIlIK-SATKTDC 224  

                   eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd
                      + lrE++++  l +HpNiV ++ + +   e     + +V +      
   mKIAA1369   225 --MKVLREVKVLAGL-QHPNIVGYHTAWI---EH----VHVVQP------ 258  

                   LldfLrkhr.........................................
                     d    + ++ +  +++++++++++ ++++++++    + +++++++ +
   mKIAA1369   259 -QDRVPIQLpslevlseqegdrdqggvkdnessssivfaeltpekekpfg 307  

                   ..................................................
                   +++ ++++++  + + +   +++++++++ + ++++ ++ + ++  +++ 
   mKIAA1369   308 esevknennnlvsytanlvvrnssesessielqedgltdlsvrpvvrhql 357  

                   ..................................................
                   + +++++ +++ ++++++++++ +  ++++ + +   + + +  + +  +
   mKIAA1369   358 plghsselegnftstdessegnlnllgqtevryhlmlhiqmqlcelslwd 407  

                   ...............egrpLtlkd.LlsfalQiAkGMeYLesknfvHRDL
                     +++++++++  ++   p  ++    ++ ++  +G  Y +++++vHRDL
   mKIAA1369   408 witernkrsreyvdeAACPYVMASvATKIFQELVEGVFYIHNMGIVHRDL 457  

                   AARNcLVsenl.vVKIsDFGLa.RdiynddyYvrkkgggklPvkWm....
                     RN+ ++ + ++VKI+DFGLa  di      ++  +       W+++++
   mKIAA1369   458 KPRNIFLHGPDqQVKIGDFGLAcADI------IQNAD-------WTnrng 494  

                   ................APEslkygkFtskSDVWSFGVlLWEiftlGeqPF
                   +++++++++ ++    +PE l  + +  kSD +S GV L E+f     P 
   mKIAA1369   495 kgtrthtsrvgtclyaSPEQLEGSQYDAKSDMYSLGVILLELFQ----P- 539  

                   Ypgm.sneevlellyedGyRLpr.PenCPdelYdlMlqCWaedPedRPtF
                   +      + vl  + + G+  +   + CP     + l+   ++ ++RP+ 
   mKIAA1369   540 FGTEmERATVLTGV-RTGRIPESlSKRCPVQAKYIQLLTG-RNVSQRPSA 587  

                   sel.verL<-*
                    +l +++L   
   mKIAA1369   588 LQLlQSEL    595  

Pkinase: domain 1 of 1, from 183 to 596: score 163.7, E = 3e-45
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      +e l +lG+G++G+Vyk ++k +g+ +A+K+i  +++ +  ++  +r
   mKIAA1369   183    FEELAILGKGGYGRVYKVRNKLDGQHYAIKKILIKSATKTDCMKVLR 229  

                   rsEiqilkrLsHpNIvrlidvfed..........................
                     E+++l+ L+HpNIv ++ ++ ++ +  +++++ + + ++ +  +++++
   mKIAA1369   230 --EVKVLAGLQHPNIVGYHTAWIEhvhvvqpqdrvpiqlpslevlseqeg 277  

                   ..................................................
                   ++++++ ++++++++    + +++++++ ++++ ++++++  + + +   
   mKIAA1369   278 drdqggvkdnessssivfaeltpekekpfgesevknennnlvsytanlvv 327  

                   ..................................................
                   +++++++++ + ++++ ++ + ++  +++ + +++++ +++ ++++++++
   mKIAA1369   328 rnssesessielqedgltdlsvrpvvrhqlplghsselegnftstdesse 377  

                   ...........kdhly..lVlEycegGLrlldLfdyls......e...tr
                   ++ +  ++++ + hl  ++ + +ce      +L+d+++++++++++  ++
   mKIAA1369   378 gnlnllgqtevRYHLMlhIQMQLCEL-----SLWDWITernkrsReyvDE 422  

                   rkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILld.engvv
                   + +p+     +a ki+ ++++g+ Y+H++gi+HRDLKP NI+l++ + +v
   mKIAA1369   423 AACPY-VMASVATKIFQELVEGVFYIHNMGIVHRDLKPRNIFLHgPDQQV 471  

                   daflKiaDFGlAkkls...........t.sss.lttfvGTpwYmAPEvll
                       Ki+DFGlA+ ++  ++ + ++++ +  ++ t++vGT  Y++PE l 
   mKIAA1369   472 ----KIGDFGLAC-ADiiqnadwtnrnGkGTRtHTSRVGTCLYASPEQLE 516  

                   ggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgppl
                    g+ y+ k+D++SlGvil el+    PF  e         ++  ++ ++ 
   mKIAA1369   517 -GSQYDAKSDMYSLGVILLELFQ---PFGTE----MERATVLTGVRTGRI 558  

                   efdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHP
                   +++  + +++               ++L+++   ++ s+R++a ++lq++
   mKIAA1369   559 PESLSKRCPVQ-----------AKYIQLLTG---RNVSQRPSALQLLQSE 594  

                   wf<-*
                    f   
   mKIAA1369   595 LF    596  

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