hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mpm/mpm06033/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1366 ( 884 res) mpm06033 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- COesterase Carboxylesterase 716.7 1e-211 1 Abhydrolase_3 alpha/beta hydrolase fold -68.2 0.019 1 Peptidase_S9 Prolyl oligopeptidase family -76.1 0.18 1 Abhydrolase_2 Phospholipase/Carboxylesterase -82.3 0.77 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Abhydrolase_3 1/1 228 400 .. 1 247 [] -68.2 0.019 Abhydrolase_2 1/1 212 426 .. 1 236 [] -82.3 0.77 Peptidase_S9 1/1 242 464 .. 1 229 [] -76.1 0.18 COesterase 1/1 49 649 .. 1 591 [] 716.7 1e-211 Alignments of top-scoring domains: Abhydrolase_3: domain 1 of 1, from 228 to 400: score -68.2, E = 0.019 *->lvYfHGGGFvlGsldthYdalcrrLAaragavVvSVDYR......LA ++++HGG ++ G+ +++ d + Aa+ +++V +YR + + L+ mKIAA1366 228 MLFLHGGSYMEGTGNMF-DGSVL--AAYGNVIVATLNYRlgvlgfLS 271 PEhpfPA...AvdDayaAlrWlaehavgsggeddpwlelgaDpsriavaG ++ + D AlrWl e+ + ++g+Dp+ri+++G mKIAA1366 272 TGDQAAKgnyGLLDQIQALRWLSENI---------A-HFGGDPERITIFG 311 DSAGGNLAaavAqlrardrGgplaeldpdlspvrpagqvLiyPfFggtDl AG+ + ++ + + l + + mKIAA1366 312 SGAGAS-CVNLL-ILSHHS-EGL-----------FQKAIAQSG------- 340 rertesesyrlsreyadgplLtrdamdwfwrlYLpgadrddPaslasPlf +++ s s + L + rl la+ + mKIAA1366 341 -TAISSWSV--N-----YQPL------KYTRL------------LAAKVG 364 apaspdlegLsGLPPalvvvAefDpLrDegeaYAerLr..aWaGVpVelv + d r ++ + e Lr+++ V+ mKIAA1366 365 C----D--------------------REDSTEAVECLRrkS-SRELVDQD 389 eypGmiHgFll<-* + p H + mKIAA1366 390 VQPARYHIAFG 400 Abhydrolase_2: domain 1 of 1, from 212 to 426: score -82.3, E = 0.77 *->laypaivspakpaqalvIfLHGLGDtgdWyhgwafaakteaalpntk l+ p+ ++ +++ +fLHG G+ +g+++++ l + mKIAA1366 212 LNPPDTDIRDSGKKPVMLFLHG-GSYM---EGTGNMFD-GSVLAAY- 252 fifPhApeipvtlngGrrMPaWFdleglspeglkedea.....giknsae ++ i tln+ + + g++ g d+a +++ g+ + ++ mKIAA1366 253 -----GNVIVATLNYRLG------VLGFLSTG---DQAakgnyGLLDQIQ 288 tieeLidaeqktGkeALEeLIleLeIpssrIiiGGFSQGgalaLytaltl + +L ++ G +++rI i+G + G+ + ++l+ mKIAA1366 289 ALRWLSENIAHFG------------GDPERITIFGSGAGASCVNLLILSH 326 pk..pLaGiialSGalplppkfpqhptalakvdiPilliHGteD..pvvP ++ + ++ia SG+++++ +++ +p + + + + + + eD+++ v+ mKIAA1366 327 HSegLFQKAIAQSGTAISSWSVNYQPLKYT-RLLAAKVGCDREDstEAVE 375 lalgkaake..........yLkklgnpakvefkeypgmgHsicpqemqdi +k+++e +++ ++ +y++++g+ v+++ +p +p++++ mKIAA1366 376 CLRRKSSRElvdqdvqparYHIAFGP--VVDGDVVP-----DDPEILMQQ 418 ksFlskti<-* +Fl++ mKIAA1366 419 GEFLNYDM 426 Peptidase_S9: domain 1 of 1, from 242 to 464: score -76.1, E = 0.18 *->psfsvwnlqlladrGyvvavaniRGsggyGrawhdag.krdlgqnef + f+ l+a ++va n+R + + g+ +g + + mKIAA1366 242 NMFD--GSVLAAYGNVIVATLNYRLGV---LGFLSTGdQAAKGNYGL 283 dDfiaaaeyL...ieqgpyvDpdrlaiwGgSyGGyltgaalnkqrpd.lF D+i a+++L+++i+++ Dp+r+ i+G +G ++ + ++++++lF mKIAA1366 284 LDQIQALRWLsenIAHF-GGDPERITIFGSGAGASCVNLLILSHHSEgLF 332 kaavavvpvvDwltymsdtslpysfteaeymewgnpwdeneegYrylspy + a+a+++ + + ++s + + y + + g ++ + mKIAA1366 333 QKAIAQSGTA--ISSWSVN-----YQPLKYTRLLA----AKVGCDREDST 371 spydnvkaq..........ayppl.LlihGlhDdRVpyqealklvaaLqa ++ ++++++++ +++ + +++ + D V++ ++ l +q mKIAA1366 372 EAVECLRRKssrelvdqdvQPARYhIAFGPVVDGDVVPDDPEIL---MQ- 417 lktGknpflllifpdeGHdLSgggkprnkrlk....eyarllaFllkvlg + ++++li ++G g + ++++ ++++++ a+ ++F + ++ mKIAA1366 418 -QGEFLNYDMLIGVNQGE---GLKFVEDSA-EsedgVSASAFDFTVSNFV 462 gt<-* mKIAA1366 463 DN 464 COesterase: domain 1 of 1, from 49 to 649: score 716.7, E = 1e-211 *->mllllllllllllflavvataptsp..............edp.vVeT m+ll l l++l +++ + + p + +++++ + ++ ++e +vV+T mKIAA1366 49 MWLLALCLVGLAGAQRGGGG-PGGGapggpglglgslgeERFpVVNT 94 syvgGkvrGlrvkvdg.gnkpvyaFlGIPYAkPPvGeLRFkkPqPypepW y G+vrG+r++ ++++ +pv +FlG+PYA PP+G +RF++P++ p +W mKIAA1366 95 AY--GRVRGVRRELNNeILGPVVQFLGVPYATPPLGARRFQPPEA-PASW 141 tgvldATkygpaCpQ.ndlgfpgFslal.hv.gsemwnkntg......ks gv++AT+ +paCpQ+ + g al+++ ++ ++ n++ + ++ mKIAA1366 142 PGVRNATTLPPACPQnLH-G------ALpAImLPVWFTDNLEaaatyvQN 184 mSEDCLYLNVytPklasesk...................klPVmVwIHGG +SEDCLYLN y+P+ + + +++++ + ++++++ ++++k PVm + HGG mKIAA1366 185 QSEDCLYLNLYVPTEDGPLTkkrdeatlnppdtdirdsgKKPVMLFLHGG 234 GFqsGsassvtlddydgpdlaasedVVVVtiNYRLGalGFLstgdselpp +++G++ +++dg++laa+++V+V t+NYRLG+lGFLstgd+ ++ mKIAA1366 235 SYMEGTG-----NMFDGSVLAAYGNVIVATLNYRLGVLGFLSTGDQAAK- 278 ppGNaGLlDQvlALrWVqeNIaaFGGDPdnVTlFGeSAGAaSVsllllSp GN+GLlDQ++ALrW eNIa+FGGDP+++T+FG +AGA++V+ll lS mKIAA1366 279 --GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILS- 325 pqsrGLFhrAIlqSGsalspwaits.pearnrakrlAkllGCpgedseel +s+GLF++AI qSG+a s+w+++++p +++++ lA ++GC+ eds+e mKIAA1366 326 HHSEGLFQKAIAQSGTAISSWSVNYqP--LKYTRLLAAKVGCDREDSTEA 373 veCLRkksaeelldaqwklllleefgffplfaFgPVvdGdtpdaflpkdP veCLR+ks++el+d++ +++++ f PVvdGd ++p+dP mKIAA1366 374 VECLRRKSSRELVDQDV--QPARYHIAFG-----PVVDGD----VVPDDP 412 eellkegnfnkvPlliGvtsdEGllflayvl.dp.lsadllseidnedlf e+l+++g f ++++liGv++ EGl f+ + ++ + s + +++ mKIAA1366 413 EILMQQGEFLNYDMLIGVNQGEGLKFVEDSAeSEdGV----SASAFDF-T 457 lellpellpgase.ltlklreeiadalkeeYtdd.ddnseesr.dalldl ++++++l+g++e++ + +++++k++Ytd+ d+++ e+r++ ll l mKIAA1366 458 VSNFVDNLYGYPEgK-----DVLRETIKFMYTDWaDRDNGEMRrKTLLAL 502 lsDylFvcPilrlaaaraakagapvYlYrFdyrssdsfnqylinllwppw ++D+++v+P +++ a+ +a++++pvY+Y F +++ ++ +p+w mKIAA1366 503 FTDHQWVAP-AVATAKLHADYQSPVYFYTFYHHCQ--------AEGRPEW 543 rgvsHgdelsYvFGnpls.k.ly....steeeeklssrrmmrywtnFAkt + Hgdel+YvFG+p+++ ++ + ++++ + +ls +++m+ywtnFAkt mKIAA1366 544 ADAAHGDELPYVFGVPMVgAtDLfpcnFSKNDVMLS-AVVMTYWTNFAKT 592 GnPN.............ngessglpkWppytkeeqkyylpitllnisqk. G+PN++ +++++ +++++ +++++W +++++e + yl+i+l+++++++ mKIAA1366 593 GDPNqpvpqdtkfihtkPNR-FEEVVWSKFNSKEKQ-YLHIGLKPRVRDn 640 lreldPrkvkcafw<-* +r+++ +afw mKIAA1366 641 YRANK-----VAFW 649 //