hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mpm/mpm06205/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1338  ( 1397 res)   mpm06205

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
S_TKc    Serine/Threonine protein kinases, catalytic    161.8      7e-44   1
TyrKc    Tyrosine kinase, catalytic domain              -49.6    4.6e-08   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
S_TKc      1/1     338   749 ..     1   231 []   161.8    7e-44
TyrKc      1/1     338   749 ..     1   280 []   -49.6  4.6e-08

Alignments of top-scoring domains:
S_TKc: domain 1 of 1, from 338 to 749: score 161.8, E = 7e-44
                   *->YellkklGkGaFGkVylardkktgrlvAiKvik..............
                      +e l++lGkGaFG V ++++k +g  +A+K+i+ ++ +++ ++ +++
   mKIAA1338   338    FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPinpasrhfrrikge 384  

                   ..................................................
                    +  ++ ++++  +  +   ++++++  +++++++ +++ ++++ + +++
   mKIAA1338   385 vtllsrlhhenivryynawierherpavpgtpppdctpqaqdspatygkt 434  

                   ..................................................
                   ++++++ ++ +   +++  +++ + +++ +++++++ + +++++++++++
   mKIAA1338   435 sgdteelgsveaaapppilsssvewstsaerststrfpvtgqdsssdeed 484  

                   .......................erilrEikiLkk......dHPNIVkLy
                   ++++++  +++  + ++++++   + + E +  ++++++ ++ +      
   mKIAA1338   485 ederdgvfsqsflpasdsdsdiiFDNEDENSKSQNqdedcnQKDGSHEVE 534  

                   dvfed...dklylVmEyceGdlGdLfdllkkrgrrglrkvlsE.earfyf
                    +   +  ++ly+ mEyce    +L+d +++          + ++ +++f
   mKIAA1338   535 PSVTAeavHYLYIQMEYCEK--STLRDTIDQGLF------RDTsRLWRLF 576  

                   rQilsaLeYLHsqgIiHRDLKPeNiLLds..hvKlaDFGlArql......
                   r+il++L+Y+H++g iHRDLKP Ni+Lds++hvK++DFGlA+     + +
   mKIAA1338   577 REILDGLAYIHEKGMIHRDLKPVNIFLDSddHVKIGDFGLATDHlaftae 626  

                   ....................ttfvGTpeYmAPEvl.....gYgkpavDiW
                   ++++++ +++  +++++ + t +vGT  Y++PEv +++++ Y+  +vD  
   mKIAA1338   627 gkqddqagdrviksdpschlTGMVGTALYVSPEVQgstksAYNQ-KVDLF 675  

                   SlGcilyElltGkpPFp..qldlifkkig...............Speakd
                   SlG+i++E+ +  p    ++   ++++++++++++ +++ ++++    k+
   mKIAA1338   676 SLGIIFFEMSY-HPMVTasERIFVLNQLRdptspkfpddfddgeHTKQKS 724  

                   LikklLvkdPekRlta.eaLedeldikaHPff<-*
                    i+ lL+ dP+kR+ta e+L+        + +   
   mKIAA1338   725 VISWLLNHDPAKRPTAmELLK-------SELL    749  

TyrKc: domain 1 of 1, from 338 to 749: score -49.6, E = 4.6e-08
                   *->ltlgkkLGeGaFGeVykGtlk...ieVAVKtLkeda....keeFlrE
                       + ++ LG GaFG V k + k ++   AVK +  +  +++ + +  E
   mKIAA1338   338    FEELQLLGKGAFGAVIKVQNKldgCCYAVKRIPINPasrhFRRIKGE 384  

                   akiMkklGgkHpNiVkLlGvcteegrrFmevePlmivmEymegGdLldyL
                     ++++l  +H+NiV+ + + +e                           
   mKIAA1338   385 VTLLSRL--HHENIVRYYNAWIE--------------------------- 405  

                   rknrpk............................................
                   r  rp  +++++++ +++ ++++ + +++++++++ ++ +   +++  ++
   mKIAA1338   406 RHERPAvpgtpppdctpqaqdspatygktsgdteelgsveaaapppilss 455  

                   ..................................................
                   + + +++ +++++++ + +++++++++++++++++  +++  + ++++++
   mKIAA1338   456 svewstsaerststrfpvtgqdsssdeedederdgvfsqsflpasdsdsd 505  

                   ..................................................
                      +++++++++++++++ ++++++++ +++ + +  +    + +  +++
   mKIAA1338   506 iifdnedensksqnqdedcnqkdgshevepsvtaeavhylyiqmeyceks 555  

                   ...........lslsdLlsfAlQIAkGMeYLesknfvHRDLAARNcLvge
                   + +++ +++    +s L      I +G +Y+++k+ +HRDL   N+ +++
   mKIAA1338   556 tlrdtidqglfRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDS 605  

                   nkvvKIsDFGLsRdlyddDkkGeskdyYrkkggkggktllPir.......
                   + +vKI+DFGL+ d+       ++++  ++     g+    i+++++ + 
   mKIAA1338   606 DDHVKIGDFGLATDHLAF---TAEGKQDDQ----AGD--RVIKsdpschl 646  

                   ........WmAPEsl..kdgkFtskSDVWSFGVlLWEiftlGeqPYpgei
                   ++  ++    +PE+ ++ ++ ++ k D +S G+  +E+       Y  + 
   mKIAA1338   647 tgmvgtalYVSPEVQgsTKSAYNQKVDLFSLGIIFFEM------SYHPM- 689  

                   qqfmsnee...vleylkkGyRlpkPendlpiSs.vtCPdelYdlMlqCWa
                      ++++e+  vl++l++   ++ P++     ++ + +++  +++++  +
   mKIAA1338   690 ---VTASErifVLNQLRDPTSPKFPDD-----FdDGEHTKQKSVISWLLN 731  

                   edPedRPtFsel..verl<-*
                   +dP++RPt  el + e+l   
   mKIAA1338   732 HDPAKRPTAMELlkSELL    749  

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