hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mpm/mpm06205/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1338 ( 1397 res) mpm06205 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 176.3 4.9e-49 1 Pkinase_Tyr Protein tyrosine kinase -1.8 9.2e-12 1 APH Phosphotransferase enzyme family -7.9 0.12 1 tRNA-synt_2b tRNA synthetase class II core domain (G, -19.0 0.00079 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- APH 1/1 340 655 .. 1 256 [] -7.9 0.12 Pkinase_Tyr 1/1 338 748 .. 1 272 [] -1.8 9.2e-12 Pkinase 1/1 338 749 .. 1 287 [] 176.3 4.9e-49 tRNA-synt_2b 1/1 807 971 .. 1 228 [] -19.0 0.00079 Alignments of top-scoring domains: APH: domain 1 of 1, from 340 to 655: score -7.9, E = 0.12 *->elrplsgGasnrtylvttgdgdapryvlrlappg...eaaeelerEa el+ l+ Ga + ++ +++ d+ +y +++ p + ++ +++ E+ mKIAA1338 340 ELQLLGKGAFG-AVIKVQNKLDGCCYAVKRIPINpasRHFRRIKGEV 385 avlrhLaalgipvpvpvPrvlaggtdgeglgl.pfllleglpGevlsrpn +l +L+ + i v r + +++++ +++g p + ++ mKIAA1338 386 TLLSRLHHENI-----V-RYYN-----AWIERhERPAVPGTPPPDCTP-- 422 alspaerpallealarlLarLHqvd.ppalpla................. ++ d+p++ + +++++++ ++ + +++ mKIAA1338 423 ---------------------QAQDsPATYGKTsgdteelgsveaaappp 451 .................................................. +++ + +++ +++++++ + +++++++++++++++++ +++ + ++ mKIAA1338 452 ilsssvewstsaerststrfpvtgqdsssdeedederdgvfsqsflpasd 501 ..........................................rrlerrlk ++++ +++++++++++++++ ++++++++ +++ + + ++ +++ + mKIAA1338 502 sdsdiifdnedensksqnqdedcnqkdgshevepsvtaeavhYLYIQMEY 551 llrqlaaalarlvaaelldeerglllelaerllaaleallp...ppvlvH +++ ++ ++++ ++ +l++ l++++++ l+ ++ + +H mKIAA1338 552 CEKSTLRDTIDQGLFRDTS-------RLWR-LFREILDGLAyihEKGMIH 593 GDlhpgNvlvddapdggrvsGvIDfedaglGdpayDlAmllrslfgeefg +Dl p N+++d ++d + + Df+ a+ lA +++ +++ mKIAA1338 594 RDLKPVNIFLD-SDDHVK---IGDFGLATDH-----LAFTAEG----KQD 630 pefldaylaaygrqfaapglerlrel<-* ++ d+ ++ + ++ +g+ +++ mKIAA1338 631 DQAGDRVIKSDPS-CHLTGMVGTALY 655 Pkinase_Tyr: domain 1 of 1, from 338 to 748: score -1.8, E = 9.2e-12 *->lklgkkLGeGaFGeVyk......GtlkgsgegtkikVAVKtLkeiga ++ ++ LG+GaFG V k +++ +G ++ AVK ++ + mKIAA1338 338 FEELQLLGKGAFGAVIKvqnkldGCCY----------AVKRIPI-NP 373 sseeieredFlrEAsiMkklGdHpNiVrLlGvct................ s++ + E+ ++++l +H+NiVr++ + +++++++ +++++++ mKIAA1338 374 ASRH--FRRIKGEVTLLSRL-HHENIVRYYNAWIerherpavpgtpppdc 420 .................................................. +++ ++++ + +++++++++ ++ + +++ +++ + +++ +++++++ mKIAA1338 421 tpqaqdspatygktsgdteelgsveaaapppilsssvewstsaerststr 470 .................................................. + +++++++++++++++++ +++ + ++++++ ++++++++++++ mKIAA1338 471 fpvtgqdsssdeedederdgvfsqsflpasdsdsdiifdnedensksqnq 520 ...................kegePggpglyiVtEymegGdLldfLrkhre +++ ++++++++ +++ + + lyi +Ey+e+ L+d + mKIAA1338 521 dedcnqkdgshevepsvtaEAVHY----LYIQMEYCEKSTLRDTIDQ--- 563 grpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLVsenlvVKIsD g ++++L ++i +G++Y ++k+++HRDL N+ ++++ +VKI+D mKIAA1338 564 GLFRDTSRLWRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGD 613 FGLaRdi.ynddyYvrkkgggklPv................kWmAPEslk FGLa d+ + + ++ + + v +++++ + ++ ++ +PE + mKIAA1338 614 FGLATDHlAFTAEG-KQDDQAGDRViksdpschltgmvgtaLYVSPE-VQ 661 ygk...FtskSDVWSFGVlLWEiftlGeqP.....FYpgmsneevlelly + ++ ++ k D S G+ +E+ + +++ F vl++l mKIAA1338 662 GSTksaYNQKVDLFSLGIIFFEMSYHPMVTaseriF--------VLNQL- 702 edGyRLprP......enCPdelYdlMlqCWaedPedRPtFsel.verL<- +d + P++ +++e + + +++ ++dP++RPt el ++L mKIAA1338 703 RDPTSPKFPddfddgE--HTKQKSVISWLLNHDPAKRPTAMELlKSEL 748 * mKIAA1338 - - Pkinase: domain 1 of 1, from 338 to 749: score 176.3, E = 4.9e-49 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr +e l+ lG+G+fG V k ++k +g+ +AvK+i+ ++ +++++ mKIAA1338 338 FEELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKG- 383 rsEiqilkrLsHpNIvrlidvfed.......................... E+ +l rL+H+NIvr++ ++ ++++++ +++++++ +++ ++++ + mKIAA1338 384 --EVTLLSRLHHENIVRYYNAWIErherpavpgtpppdctpqaqdspaty 431 .................................................. +++++++++ ++ + +++ +++ + +++ +++++++ + ++++++++ mKIAA1338 432 gktsgdteelgsveaaapppilsssvewstsaerststrfpvtgqdsssd 481 .................................................. +++++++++ +++ + ++++++ +++++++++++++++ +++++++ mKIAA1338 482 eedederdgvfsqsflpasdsdsdiifdnedensksqnqdedcnqkdgsh 531 ..........kdhlylVlEycegGLrlldLfdylsetrrkgpllfsedea + +++ + + +ly+ +Eyce+ L d + +g + + + mKIAA1338 532 evepsvtaeaVHYLYIQMEYCEKS----TLRDTID----QGLF-RDTSRL 572 kkialQilrgleYLHsngiiHRDLKPeNILldengvvdaflKiaDFGlAk + +++il gl+Y+H++g iHRDLKP NI+ld++++v Ki+DFGlA mKIAA1338 573 WRLFREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHV----KIGDFGLAT 618 kls..................t.sss.lttfvGTpwYmAPEvll.ggngy + + +++++++ +++ + ++s +lt+ vGT Y++PEv ++ + y mKIAA1338 619 DHLaftaegkqddqagdrvikSdPSChLTGMVGTALYVSPEVQGsTKSAY 668 gtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdsp +kvD +SlG+i++e+ +e + ++l ++ +++++f+ + mKIAA1338 669 NQKVDLFSLGIIFFEMSYHPMVTASE-----RIFVLNQLRDPTSPKFPDD 713 ewdsisrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* +d + k++i+++Ln DP+kR+ta+e+l+++ + mKIAA1338 714 FDDGEH-----------TKQKSVISWLLNHDPAKRPTAMELLKSELL 749 tRNA-synt_2b: domain 1 of 1, from 807 to 971: score -19.0, E = 0.00079 *->lGarlrralenfireelkkryGyqevdtPilepeelwerksGhwddf + a++++ +++ i +++k r+G++ + tP l p+ h mKIAA1338 807 RTAKIQQLVCETIVRVFK-RHGAVQLCTPLLLPRNRQIY-E-H---- 846 vdeekmyrfkdrggfRaDHlirkhdldElasaknkcvcGLtprFNLMFTI e f+d++g + mKIAA1338 847 -NE--AALFMDHSG-------M--LV------------------------ 860 GPgegyLrPtaevgiarlfkneilssyrdLPlklyqigpcFRyEagsaGr +L +++ v++ar+++++ + L lk+y i ++F r mKIAA1338 861 -----MLPFDLRVPFARYVARNNI-----LNLKRYCIERVF--------R 892 prrGlgRvR..eFtqveaeifgtpeqHPFsseeedeellelaeeilkaL. pr+ l R +++e + ++i++++ s +e++ ++ei ++++ mKIAA1338 893 PRK-LDRFHpkELLECAFDIVTSTTN----SSLPTAETIYTIYEIIQEFp 937 GlseepyrvvlsdrGdlggsasktgdleawlpaq<-* l e++y ++l+++ l + ++g e++l + mKIAA1338 938 ALQERNYSIYLNHTMLLKAILLHCGIPEDKLSQV 971 //