hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbh/mbh02485/w3open/interpro/cnk_1/seq.in
- - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - -
Query:  mKIAA1308  ( 924 res)   mbh02485

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RasGEF   Guanine nucleotide exchange factor for Ras-l   407.2   9.1e-118   1
RasGEFN  Guanine nucleotide exchange factor for Ras-l   138.9    5.5e-37   1
RA       Ras association (RalGDS/AF-6) domain            87.9    1.2e-21   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RasGEFN    1/1     128   266 ..     1   172 []   138.9  5.5e-37
RasGEF     1/1     392   659 ..     1   261 []   407.2 9.1e-118
RA         1/1     808   895 ..     1   102 []    87.9  1.2e-21

Alignments of top-scoring domains:
RasGEFN: domain 1 of 1, from 128 to 266: score 138.9, E = 5.5e-37
                   *->ckggliKgGtlekLiehLteardkgkvdlkaDptfvetFLlTYRsFi
                      ck++++K+GtlekL+ehL++a++      + D+++v++FL+TYR+F+
   mKIAA1308   128    CKVRTVKAGTLEKLVEHLVPAFQ------GSDLSYVTVFLCTYRAFT 168  

                   ttqeLlqkLldrYnaippeivsrSlelkatea.seglsfedysknaipvg
                   ttq++l++L +rY +++              a+s   +   y        
   mKIAA1308   169 TTQQVLDLLFKRYGRCDAL-----------TAsSRYGCILPY-------- 199  

                   faetdiivkekvnprriqnrVlnilrlWvenywedFeedpklnlfLeelf
                          +++ + + +++n + +il +W+++y+edF+++p ++++L++l 
   mKIAA1308   200 ------SSEDGGPQDQLKNAISSILGTWLDQYSEDFCQPP-DFPCLKQLV 242  

                   lelvedkkdkgpglekslanilerls<-*
                   +++   +  +g++le++++ +l++l    
   mKIAA1308   243 AYVQLNM--PGSDLERRAHLLLAQLE    266  

RasGEF: domain 1 of 1, from 392 to 659: score 407.2, E = 9.1e-118
                   *->lllldpeelAeQLTlldfelFrkIepsEllgsvwgkrskkspsplap
                      lll++p+ +AeQ Tl+d+elF+k++p ++lgs+w++r+kk++++lap
   mKIAA1308   392    LLLFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAP 438  

                   qnleafierfNevsnwVateIlkqttlkpkkRaevlskFIkVAkhcreLn
                    +++a++++fN+v+n+V+t++l+++++k+ +Ra+v++++I+VA++cr L+
   mKIAA1308   439 -TIRATVAQFNNVANCVITTCLGDQSMKAPDRARVVEHWIEVARECRALK 487  

                   NFnSlmAIvsaLssspIsRLkkTWeklsskykklfeeLeelldpserNfk
                   NF+Sl+AI+saL+s++I+RLkkTWe++s+++ ++f++L+e+++++ +N++
   mKIAA1308   488 NFSSLYAILSALQSNAIHRLKKTWEEVSRDSFRVFQKLSEIFSDE-NNYS 536  

                   nYReaLkscnksp..................nvqppcvPflGvyLkDLtf
                    +Re+L ++++s+  + + ++++ ++++++++v +++vP+lG++L+DL++
   mKIAA1308   537 LSRELLIKEGTSKfatlemnprraqrrqketGVIQGTVPYLGTFLTDLVM 586  

                   idegnpdflengtkglvNFeKrrkiakilreirqlqsacqpynlkpnrnd
                   +d++++d+l+    +l+NFeKrrk+++++++i++lqsac++y ++p+ ++
   mKIAA1308   587 LDTAMKDYLYG---RLINFEKRRKEFEVIAQIKLLQSACNNYSIAPE-EH 632  

                   iqellrasrplevlpeeedelyelSlriEPrv<-*
                   ++ ++ra   +e+l+e   e+y lS+++EP++   
   mKIAA1308   633 FGTWFRA---MERLSEA--ESYTLSCELEPPS    659  

RA: domain 1 of 1, from 808 to 895: score 87.9, E = 1.2e-21
                   *->dtyvlrVyvddlsavdpgqtyktlrvskrtTardViqqllekfhltd
                      d++++rV+ d+    d+g++yk+++v+++++a++Vi++++ k++l+ 
   mKIAA1308   808    DCCIIRVSLDV----DNGNMYKSILVTSQDKAPTVIRKAMDKHNLDE 850  

                   edpeeYvLvevlpsggkErvLlddenPlqlqklwprdaksprqsslrFvL
                   + pe+Y+Lv+   s++ + ++++++n++++++          + +++F L
   mKIAA1308   851 DEPEDYELVQII-SEDHKLKIPENANVFYAMNS---------TANYDFIL 890  

                   rkrdd<-*
                   +kr +   
   mKIAA1308   891 KKRTF    895  

//