hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbh/mbh00665/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1297  ( 1171 res)   mbh00665

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
S_TKc    Serine/Threonine protein kinases, catalytic    234.1    1.2e-65   1
IGc2     Immunoglobulin C-2 Type                         46.1    4.5e-09   1
IG       Immunoglobulin                                  42.5    5.5e-08   1
TyrKc    Tyrosine kinase, catalytic domain              -20.5    7.2e-10   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
IGc2       1/1     508   576 ..     1    56 []    46.1  4.5e-09
IG         1/1     502   587 ..     1    58 []    42.5  5.5e-08
S_TKc      1/1     870  1122 ..     1   231 []   234.1  1.2e-65
TyrKc      1/1     870  1122 ..     1   280 []   -20.5  7.2e-10

Alignments of top-scoring domains:
IGc2: domain 1 of 1, from 508 to 576: score 46.1, E = 4.5e-09
                   *->leGqsVtLtCpasgdpvpnItWlk.gkplp............sgstL
                      leG+++tL C  ++ p+p I+W k+ ++l ++++    + +++++ L
   mKIAA1297   508    LEGEAATLLCLPAACPAPRISWMKdKQSLRsepsvvivsckdGRQLL 554  

                   tiknvsleDsGlYtCvArNsvg<-*
                   +i ++ + ++GlY+C+A+N  g   
   mKIAA1297   555 SIPRAGKRHAGLYECSATNVLG    576  

IG: domain 1 of 1, from 502 to 587: score 42.5, E = 5.5e-08
                   *->pp.vtvkeGesvtLtC.as.....titWy..................
                       ++++  eGe +tL C  +  + ++i+W++++++ ++ ++    + +
   mKIAA1297   502    LKdQVLLEGEAATLLClPAacpapRISWMkdkqslrsepsvvivsck 548  

                   .....LtI.nvtpeDsesgGtYtCaat..sgsasseqgttLtVl<-*
                   ++++ L I+++ + ++   G Y C at+  gs++s  + t+ V    
   mKIAA1297   549 dgrqlLSIpRAGKRHA---GLYECSATnvLGSITS--SCTVAVA    587  

S_TKc: domain 1 of 1, from 870 to 1122: score 234.1, E = 1.2e-65
                   *->YellkklGkGaFGkVylardkktgrlvAiKvik......erilrEik
                      Y++l++  +G FG+V+ +r++ tgr +  K+++   ++++r+l+E +
   mKIAA1297   870    YTFLEEKARGRFGVVRSCRENATGRTFVAKIVPyaaegkRRVLQEYE 916  

                   iLkk.dHPNIVkLydvfed.dklylVmEyceGdlGdLfdllkkrgrrglr
                   +L+  +H+ +  L++++ ++ +l l+ E c++   +L+  l +r r    
   mKIAA1297   917 VLRTlHHERLMSLHEAYITpRYLVLIAESCGN--RELLCGLSDRFR---- 960  

                   kvlsE.earfyfrQilsaLeYLHsqgIiHRDLKPeNiLLds..hvKlaDF
                     +sE++++ y+ Q+l++L+YLH ++++H D+KP+N+LL  ++ +K+ DF
   mKIAA1297   961 --YSEdDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAAdnALKIVDF 1008 

                   GlArql........ttfvGTpeYmAPEvl...gYgkpavDiWSlGcilyE
                   G+A  ++++  ++  +  GT+e+mAPE++++++ g  a DiW  G++ y+
   mKIAA1297  1009 GSAQPYnpqalkplGHRTGTLEFMAPEMVkgdPIGS-ATDIWGAGVLTYI 1057 

                   lltGkpPFp...qldlifkkig............SpeakdLikklLvkdP
                   +l+G+ PF++++ +++  +++g++ +    ++++S++a  +++k L + P
   mKIAA1297  1058 MLSGYSPFYepdPQETEARIVGgrfdafqlypntSQSATLFLRKVLSVHP 1107 

                   ekRlta.eaLedeldikaHPff<-*
                     R++ +++L+       HP++   
   mKIAA1297  1108 WSRPSLqDCLA-------HPWL    1122 

TyrKc: domain 1 of 1, from 870 to 1122: score -20.5, E = 7.2e-10
                   *->ltlgkkLGeGaFGeVykGtlk....ieVAVKtLkeda...keeFlrE
                       t++++  +G FG+V+ ++ + ++++ VA  ++ ++a ++k+  l+E
   mKIAA1297   870    YTFLEEKARGRFGVVRSCRENatgrTFVA--KIVPYAaegKRRVLQE 914  

                   akiMkklGgkHpNiVkLlGvcteegrrFmevePlmivmEymegGdLldyL
                    ++++ l  +H+ +  L+ + +++         l ++ E + +  Ll  L
   mKIAA1297   915 YEVLRTL--HHERLMSLHEAYITP-------RYLVLIAESCGNRELLCGL 955  

                   rknrpklslsdLlsfAlQIAkGMeYLesknfvHRDLAARNcLvgenkvvK
                    ++ +  s +d   + +Q  +G +YL+ +++ H D+   N L+++++  K
   mKIAA1297   956 SDRFR-YSEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNALK 1004 

                   IsDFGLsRdlyddDkkGeskdyYrkkggkggktllPirWmAPEslkdgkF
                   I DFG +               +      g +t   +  mAPE  k    
   mKIAA1297  1005 IVDFGSAQPYNPQ-------ALKPL----GHRT-GTLEFMAPEMVKGDPI 1042 

                   tskSDVWSFGVlLWEiftlGeqPYpgeiqqfmsneevleylkkGyRlpkP
                    s++D+W  GVl + i+  G +P ++      +++e  +++  G+     
   mKIAA1297  1043 GSATDIWGAGVLTY-IMLSGYSPFYE-----PDPQETEARIVGGRFDAFQ 1086 

                   endlpiSsvtCPdelYdlMlqCWaedPedRPtFsel..verl<-*
                    +      +  ++      ++     P +RP+ +++  +  l   
   mKIAA1297  1087 LY------PNTSQSATLFLRKVLSVHPWSRPSLQDClaHPWL    1122 

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