hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbh/mbh00665/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1297 ( 1171 res) mbh00665 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 219.0 7e-62 1 I-set Immunoglobulin I-set domain 72.7 7.7e-18 1 ig Immunoglobulin domain 30.2 4.8e-05 1 fn3 Fibronectin type III domain 13.4 0.074 1 Pkinase_Tyr Protein tyrosine kinase -33.9 9.2e-10 1 Extensin_2 Extensin-like region -146.6 0.95 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- ig 1/1 510 571 .. 1 65 [] 30.2 4.8e-05 I-set 1/1 496 587 .. 1 97 [] 72.7 7.7e-18 fn3 1/1 590 672 .. 1 84 [] 13.4 0.074 Extensin_2 1/1 568 859 .. 1 385 [] -146.6 0.95 Pkinase 1/1 870 1122 .. 1 287 [] 219.0 7e-62 Pkinase_Tyr 1/1 870 1122 .. 1 272 [] -33.9 9.2e-10 Alignments of top-scoring domains: ig: domain 1 of 1, from 510 to 571: score 30.2, E = 4.8e-05 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq Ge +tL C + p ++++W +++++l ++ +v ++ +++++ mKIAA1297 510 GEAATLLCLP--AACPAPRISWMKDKQsLRsEPSVVIVSCKDGRQL- 553 tsLtitnvtpeDggtYtCvv<-* L+i ++ + ++g Y C + mKIAA1297 554 --LSIPRAGKRHAGLYECSA 571 I-set: domain 1 of 1, from 496 to 587: score 72.7, E = 7.7e-18 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+F +k+kd++ eGe+a++ C +P P +sW Kd q l+s mKIAA1297 496 PVFHIKLKDQVLLEGEAATLLCLPAACPAPRISWMKDKQSLRS---- 538 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtVq ++ + ++ + +g++ L I+++ ++ +G+Y C AtN G+ ++s+++ V mKIAA1297 539 EPSVVIVSCK-DGRQLLSIPRAGKRHAGLYECSATNVLGSITSSCTVAVA 587 <-* mKIAA1297 - - fn3: domain 1 of 1, from 590 to 672: score 13.4, E = 0.074 *->PsaPtnltvtdvtstsltlsWspptgngpitgYevtyRqpknggewn P++ + v + +++ + W+p + ++ Y+++ R +ge + mKIAA1297 590 PGKLAPPEVPQTYHDTALVVWKPGD-GRAPCTYTLERR---VDGESV 632 eltvpgttt..sytltgLkPgteYevrVqAvnggG.GpeS<-* + v++ + y++t L g++ +rV+ n++G+Gp+S mKIAA1297 633 WHPVSSGIPdcYYNVTQLPVGVTVRFRVACSNRAGqGPFS 672 Extensin_2: domain 1 of 1, from 568 to 859: score -146.6, E = 0.95 *->lltlvvalvslslpseasakYsYsSPPPpekpYvYkSPPpPspkyvy + + +l s+++ + Ppe p Y+ + v+ mKIAA1297 568 ECSATNVLGSITSSCTVAVARIPGKLAPPEVPQTYHDTAL-----VV 609 kSPPPpkkpYvYsSPPPPsyvykSPPPPkpyvYkSPPpPkyvYkSPPpPv P + p Y +S P S P Y Pv mKIAA1297 610 WKPGDGRAPCTYTLERRV--DGESVWHP-----VSSGIPDCYYNVTQLPV 652 ...ykYkSPPPPthsppPpyvykSPPPPpkkyvykSpPpptPvYkYkSPP + + ++ + P + k + tP SP mKIAA1297 653 gvtVRFR-----V-----ACSNRAGQGPFSNPSEKVFIRGTP----DSPA 688 PPpyvYkspPpPvkkripyvYkSPPPPpPYvYkSpPppvkkyiykspppp P + +P + + + PPP +P p p + pp+ mKIAA1297 689 QPAAAPRDAPVTSGP-----TRAPPPDSP-TSLAPTPAL------APPAS 726 ephkYvYkSPPPPpPYvyesvpeqkikYvYkSPPPPkksYkspsppkyVY + SP + s+ + + PPP +++ k + mKIAA1297 727 QAS---TLSPSTSS----MSANQALSSLKAVGPPPATPPRK--------H 761 kSpPpPvipykYkSPPPPkkkyspaPrkpyvYkSPPPPtyvYkSpPpPyk + + P PP+ + p+ +++v P t S P k mKIAA1297 762 RGLLA-T---QQAEPSPPSIVVTPSEPRSFV---PDTGTLTPTSSPQGVK 804 pptppkiyksPPPPtPvyvYkspPpippiksssppPvyvYkSpPppvysP P +P s+s v + S+Pp +++P mKIAA1297 805 -------------P--------APS-----STSLYMVTSFVSAPPAPQAP 828 PPPyvYssPPPPvyvynsaPvykksPPkhhYiYsSPPPphh<-* P +PP P+ v ++s + + sSP P mKIAA1297 829 APE----PPPEPTK------VTVRSLSPAKEVVSSPTPEST 859 Pkinase: domain 1 of 1, from 870 to 1122: score 219.0, E = 7e-62 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr y++le +G fG+V+ +++ tg++++ Ki+++ e + ++++ mKIAA1297 870 YTFLEEKARGRFGVVRSCRENATGRTFVAKIVPYAAEGK----RRVL 912 rsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdylse + E ++l+ L+H+ l++++ ++++l l+ E c++ +L ls mKIAA1297 913 Q-EYEVLRTLHHERLMSLHEAYITPRYLVLIAESCGNR----ELLCGLS- 956 trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldengv ++ ++ sed++ ++ Q+l+gl+YLH + ++H D+KP+N+Ll ++ mKIAA1297 957 --DRFRY--SEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLLAADNA 1002 vdaflKiaDFGlAkkls.t.ssslttfvGTpwYmAPEvllggngygtkvD + Ki DFG+A +++ ++l +++GT+++mAPE ++ g ++g++ D mKIAA1297 1003 L----KIVDFGSAQPYNpQaLKPLGHRTGTLEFMAPEMVK-GDPIGSATD 1047 vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi +W++Gv+ y++l+G+ PF++ d+++ ++i g++++ ++ mKIAA1297 1048 IWGAGVLTYIMLSGYSPFYEP-----DPQETEARIVGGRFDAFQLYP--- 1089 srsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-* n+s++a +++k L + P +R++ +++l HPw+ mKIAA1297 1090 ---------NTSQSATLFLRKVLSVHPWSRPSLQDCLAHPWL 1122 Pkinase_Tyr: domain 1 of 1, from 870 to 1122: score -33.9, E = 9.2e-10 *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtLkeigasseeie +++++ +G FG+V+ ++ + t+ + K++ + +a + mKIAA1297 870 YTFLEEKARGRFGVVRSCREN----ATGRTFVAKIV-P-YAAEG--- 907 redFlrEAsiMkklGdHpNiVrLl.GvctkegePggpglyiVtEymegGd ++ l+E +++++l +H+ + +L+++++t + l ++ E + + mKIAA1297 908 KRRVLQEYEVLRTL-HHERLMSLHeAYITP--RY----LVLIAESCGNRE 950 LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV Ll L + + + + d + +Q +G++YL+ +++ H D+ N L+ mKIAA1297 951 LLCGLSD---RFRYSEDDVATYVVQLLQGLDYLHGHHVLHLDIKPDNLLL 997 senlvVKIsDFGLaRdiynddyYvrkkgggklPvkWmAPEslkygkFtsk + ++ KI DFG a yn + g++ mAPE k s+ mKIAA1297 998 AADNALKIVDFGSAQP-YNPQAL-KPLGHRTGTLEFMAPEMVKGDPIGSA 1045 SDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLpr...PenC +D+W GVl + +++ G +P +++ +++e+ ++++ G+R ++ + +n+ mKIAA1297 1046 TDIWGAGVLTYIMLS-GYSP-FYEPDPQETEARIV--GGRFDAfqlYPNT 1091 PdelYdlMlqCWaedPedRPtFsel..verL<-* ++ ++ P RP+ +++ + L mKIAA1297 1092 SQSATLFLRKVLSVHPWSRPSLQDClaHPWL 1122 //