hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj16286/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1278  ( 1271 res)   mfj16286

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
S_TKc    Serine/Threonine protein kinases, catalytic    279.3    2.9e-79   1
TyrKc    Tyrosine kinase, catalytic domain               11.5    7.6e-12   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
TyrKc      1/1      41   294 ..     1   280 []    11.5  7.6e-12
S_TKc      1/1      41   464 ..     1   231 []   279.3  2.9e-79

Alignments of top-scoring domains:
TyrKc: domain 1 of 1, from 41 to 294: score 11.5, E = 7.6e-12
                   *->ltlgkkLGeGaFGeVykGtlk...ieVAVKtLkeda.....keeFlr
                       + ++++GeG FG+VykG+ k + + VA K + +  +++++++ + r
   mKIAA1278    41    YHVLEMIGEGSFGRVYKGRKKysaQVVALKFIPKLGrsekeLRNLQR 87   

                   EakiMkklGgkHpNiVkLlGvcteegrrFmevePlmivmEymegGdLldy
                   E++iM+ l   HpNiV +l    ++       + + +v+ y+e G L + 
   mKIAA1278    88 EIEIMRGL--WHPNIVHMLDSFETD-------KEVVVVTDYAE-GELFQI 127  

                   LrknrpklslsdLlsfAlQIAkGMeYLesknfvHRDLAARNcLvgenkvv
                   L + ++ l+ ++   +A Q  +   YL+s+++ HRD    N+L+++++ +
   mKIAA1278   128 LEDDGK-LPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGGI 176  

                   KIsDFGLsRdlyddDkkGeskdyYrkkggkggktllPirWmAPEslkdgk
                   K +DFG +R+            + + ++ kg+   l    m+PE   ++ 
   mKIAA1278   177 KLCDFGFARAMSTN--------TMVLTSIKGTP--L---YMSPELVEERP 213  

                   FtskSDVWSFGVlLWEiftlGeqPYpgeiqqfmsneevleylkkGyRlpk
                   + +  D WS G  L+E+   G +P +       s ++++ ++ k   + +
   mKIAA1278   214 YDHTADLWSVGCILYELA-VGTPPFYT-----TSIFQLVSLILKDPVRWP 257  

                   PendlpiS.............s.vtCPdelYdlMlqCWaedPedRPtFse
                          S  +++ +++ +++++ + P+el  l                e
   mKIAA1278   258 STI----SvitepagsdlgtpFtSRLPPELQVL--------------KDE 289  

                   lverl<-*
                     +rl   
   mKIAA1278   290 QAHRL    294  

S_TKc: domain 1 of 1, from 41 to 464: score 279.3, E = 2.9e-79
                   *->YellkklGkGaFGkVylardkktgrlvAiKvik.........erilr
                      Y++l+ +G+G+FG+Vy++r+k + ++vA+K i++ ++++++ ++++r
   mKIAA1278    41    YHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPklgrsekelRNLQR 87   

                   EikiLkk.dHPNIVkLydvfed.dklylVmEyceGdlGdLfdllkkrgrr
                   Ei+i++   HPNIV+++d+fe+++++ +V++y+eG   +Lf++l++ g+ 
   mKIAA1278    88 EIEIMRGlWHPNIVHMLDSFETdKEVVVVTDYAEG---ELFQILEDDGK- 133  

                   glrkvlsE.earfyfrQilsaLeYLHsqgIiHRDLKPeNiLLds..hvKl
                        l+E++++ +++Q++saL YLHs++I+HRD KP+NiLL +++ +Kl
   mKIAA1278   134 -----LPEdQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKggGIKL 178  

                   aDFGlArql.......ttfvGTpeYmAPEvl...gYgkpavDiWSlGcil
                   +DFG+Ar +++++   t++ GTp Ym+PE++++++Y++  +D WS+Gcil
   mKIAA1278   179 CDFGFARAMstntmvlTSIKGTPLYMSPELVeerPYDH-TADLWSVGCIL 227  

                   yElltGkpPFp..qldlifkkig...........................
                   yEl++G pPF+++ ++++  +i++++ +++++ +  +++ +++ +++ ++
   mKIAA1278   228 YELAVGTPPFYttSIFQLVSLILkdpvrwpstisvitepagsdlgtpfts 277  

                   ..................................................
                   + +++    +++  ++  ++++ ++  +   +   ++ + +++ + ++  
   mKIAA1278   278 rlppelqvlkdeqahrlapkgnqsrilrqacklmaeeakqkedqnagsal 327  

                   ..................................................
                   + +++  + ++++ + ++ + ++ +++   +   ++ ++++++++ ++ +
   mKIAA1278   328 eqedrlckvtpstapvpglkatpqessllagilasemknnwedwgageap 377  

                   ..................................................
                   +++++++ + + + + ++++++  ++ +++  +++++++++++++ +  +
   mKIAA1278   378 rtsrenhinleceqgfpeprpeamgrqstdvvdpeneepdsddewqrlle 427  

                   .....SpeakdLikklLvkdPekRlta.eaLedeldikaHPff<-*
                   ++++++ ++k+ +  l++ d  +R+  +   + +      + +   
   mKIAA1278   428 tsepgPVQLKSPLTLLCNPDFCQRIQSqLRGT-G-----EQIL    464  

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