hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj16286/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1278  ( 1271 res)   mfj16286

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Pkinase     Protein kinase domain                       289.5    4.1e-83   1
Pkinase_Tyr Protein tyrosine kinase                      39.6    2.4e-14   1
HEAT        HEAT repeat                                  29.3    8.9e-05   3

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
Pkinase_Tyr   1/1      41   279 ..     1   272 []    39.6  2.4e-14
Pkinase       1/1      41   311 ..     1   287 []   289.5  4.1e-83
HEAT          1/3     564   599 ..     1    36 []     7.5       22
HEAT          2/3    1099  1130 ..     1    36 []    12.9      3.8
HEAT          3/3    1188  1220 ..     1    36 []     9.3       12

Alignments of top-scoring domains:
Pkinase_Tyr: domain 1 of 1, from 41 to 279: score 39.6, E = 2.4e-14
                   *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtL.keigasseei
                       + ++++GeG+FG+VykG+ k       + VA K ++k  g s++e 
   mKIAA1278    41    YHVLEMIGEGSFGRVYKGRKK----YSAQVVALKFIpKL-GRSEKE- 81   

                   eredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd
                    ++ ++rE++iM+ l  HpNiV +l      ++     + +Vt y+eg  
   mKIAA1278    82 -LRNLQREIEIMRGL-WHPNIVHMLDSFET-DKE----VVVVTDYAEG-E 123  

                   LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV
                   L   L +   +++L+  +   +a+Q  +++ YL+s+++ HRD    N+L+
   mKIAA1278   124 LFQILED---DGKLPEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILL 170  

                   senlvVKIsDFGLaRdiynddyYvrkkgggklPvkWmAPEslkygkFtsk
                   ++++ +K +DFG aR++    +   + ++ k     m+PE   ++ + + 
   mKIAA1278   171 AKGGGIKLCDFGFARAM--STNT-MVLTSIKGTPLYMSPELVEERPYDHT 217  

                   SDVWSFGVlLWEiftlGeqPFYpgmsneevlellyedGyRLprPenCPde
                    D WS G+ L+E+   G +P ++  s ++++ l+      L+ P   P  
   mKIAA1278   218 ADLWSVGCILYELAV-GTPP-FYTTSIFQLVSLI------LKDPVRWPST 259  

                   lYdlMlqCWaedPedRPtFsel....verL<-*
                   +  +       +P+     s+l+++  +rL   
   mKIAA1278   260 ISVI------TEPAG----SDLgtpfTSRL    279  

Pkinase: domain 1 of 1, from 41 to 311: score 289.5, E = 4.1e-83
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      y++le +G+GsfG+Vyk+++k + ++VA+K i+k ++++k+++++ r
   mKIAA1278    41    YHVLEMIGEGSFGRVYKGRKKYSAQVVALKFIPKLGRSEKELRNLQR 87   

                   rsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdylse
                     Ei+i++ L HpNIv ++d+fe+++++ +V++y+eg     +Lf +l  
   mKIAA1278    88 --EIEIMRGLWHPNIVHMLDSFETDKEVVVVTDYAEG-----ELFQILE- 129  

                   trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldengv
                     ++g+l  +ed+++ ia Q++++l+YLHs++i+HRD+KP+NILl + g+
   mKIAA1278   130 --DDGKL--PEDQVQAIAAQLVSALYYLHSHRILHRDMKPQNILLAKGGG 175  

                   vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD
                   +    K++DFG+A+ +  ++   lt++ GTp Ym+PE++   ++y++ +D
   mKIAA1278   176 I----KLCDFGFARAM-StNTMvLTSIKGTPLYMSPELVE-ERPYDHTAD 219  

                   vWSlGvilyelltGkpPFsgevqdsldqlqlirkilgpplefdspewdsi
                    WS+G+ilyel+ G pPF+       + +ql+ +il+ p++++s  +   
   mKIAA1278   220 LWSVGCILYELAVGTPPFYTT-----SIFQLVSLILKDPVRWPSTISVIT 264  

                   srse.fr.r.l.pnlseeakdLikkcLnkDPskRlt........aeeilq
                    +  ++ +++++ +l++e++      L+   + Rl +++++++  +++++
   mKIAA1278   265 EPAGsDLgTpFtSRLPPELQ-----VLKDEQAHRLApkgnqsriLRQACK 309  

                   HPwf<-*
                      +   
   mKIAA1278   310 L--M    311  

HEAT: domain 1 of 3, from 564 to 599: score 7.5, E = 22
                   *->e.lldellplllkllnDpdpeVReaAaeaLgalaevl<-*
                      + +l +ll  ll   +D++   R+ ++ +++ l+e +   
   mKIAA1278   564    SlFL-DLLGKLLAQSDDSEQTFRRDSLMCFAVLCEAV    599  

HEAT: domain 2 of 3, from 1099 to 1130: score 12.9, E = 3.8
                   *->e.lldellplllkllnDpdpeVReaAaeaLgalaevl<-*
                      e+++     +l +ll++++  VR  A   Lg+l+++    
   mKIAA1278  1099    EsYR-----PLRSLLGHSENTVRVRAYGLLGHLLQHS    1130 

HEAT: domain 3 of 3, from 1188 to 1220: score 9.3, E = 12
                   *->e.lldellplllkllnDpdpeVReaAaeaLgalaevl<-*
                      +  +     ll  +++Dp p V+eaA+ aL +l +     
   mKIAA1278  1188    QvPQ----RLLEMACGDPQPTVKEAALIALRSLQQES    1220 

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