hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mic/mic34082/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1268  ( 1024 res)   mic34082

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
PARP     Poly(ADP-ribose) polymerase catalytic domain   178.2    1.3e-49   1
A1pp     Appr-1-p processing enzyme family              135.1    1.2e-36   2
WWE      WWE domain                                      21.9      0.011   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
A1pp       1/2      38   156 ..     1   125 []   118.5  1.3e-31
A1pp       2/2     250   368 ..     1   125 []    15.1  6.8e-05
WWE        1/1     749   824 ..     1    89 []    21.9    0.011
PARP       1/1     840  1024 .]     1   245 []   178.2  1.3e-49

Alignments of top-scoring domains:
A1pp: domain 1 of 2, from 38 to 156: score 118.5, E = 1.3e-31
                   *->VNAANsrllhGgGVcgAIaraaG.kaqrywpeafekarkqqGgdycp
                      VNAAN++l+h  G++ A+ +aaG++    ++ +++++ k  G+  + 
   mKIAA1268    38    VNAANENLKHISGLAQALSKAAGpE----LQTECDQIVKEGGV--VL 78   

                   vGeAvltpgggLpakyVIHaVGPnfsgPvgee..egdelLakAYrailrl
                    G Av++++g+Lp+ +VIHaVGP +++  g++  e+ +lL+k++r +l l
   mKIAA1268    79 PGNAVISKAGKLPCHHVIHAVGP-RWK--GDKvlECVSLLKKVVRQSLSL 125  

                   anengiksVAfPllSTGIYGgpkdraaqsll<-*
                   a+e++++s+A P+ S+GI+ +p++  +  ++   
   mKIAA1268   126 AEEHRCRSIAMPAVSAGIFDFPLELCVANIV    156  

A1pp: domain 2 of 2, from 250 to 368: score 15.1, E = 6.8e-05
                   *->VNAANsrllhGgG.VcgAIaraaG.kaqrywpeafekarkqqGgdyc
                      VN   ++l+   G++  A   +aG+k    ++e+  +    qG+  +
   mKIAA1268   250    VNSISPDLKLNKGpLSQAFLEKAGpK----LQEELTRSG--QGV-SV 289  

                   pvGeAvltpgggLpakyVIHaVGPnfsgPvgeeegdelLakAYrailrla
                   +vG+   t+g++L+ ++V+H+V P  ++ + ++ + +  ++ +r++l+  
   mKIAA1268   290 DVGTILQTSGCNLNSRHVFHVVPP-PWKSNNSAWSLKIMKNIIRDCLKTT 338  

                   nengiksVAfPllSTGIYGgpkdraaqsll<-*
                   +++++ s+AfP+++TG   +pk + a++++   
   mKIAA1268   339 ENLSLQSIAFPAIGTGNLRFPKPEFAKLII    368  

WWE: domain 1 of 1, from 749 to 824: score 21.9, E = 0.011
                   *->svappsnvagikvvvWeyerSvddnggWrpYsphvsrlIEnayaakk
                      s+a++++      v+W+y     d++   +++++++ ++E a++akk
   mKIAA1268   749    SQADYIST----YVEWQYI----DKNITQCFDKMTNMKLEVAWKAKK 787  

                   kGsVtleqvCsicGrpYtidfntmtQlreetgslsttReVrR<-*
                   k       v  i ++ +t+d+ t t +  + +   ++R V+    
   mKIAA1268   788 K---DTV-V-QIHNQDFTVDLSTNTATAPQGQTFTVQRLVKA    824  

PARP: domain 1 of 1, from 840 to 1024: score 178.2, E = 1.3e-49
                   *->LkcklepLdkdSeEykiiekylknThapthggynaYsytildIfrvq
                      L   l+ L   + Ey++++  +++T+          + +i++I+r+q
   mKIAA1268   840    LL--LVNLQTSDPEYNMVASAFRQTCS---------NFFIEKIERIQ 875  

                   rdgewerFqpkkkql.eknglhNinrrLLWHGSrltNfagILsqGLriap
                   ++ +w+r+q  kk+++ekng+   n+++L+HG+  +++   +s+G+  ++
   mKIAA1268   876 NPALWRRYQAYKKSMdEKNGNVR-NEKHLFHGTEASSLPQLNSNGF--NR 922  

                   peapvtGymDGFGkGiYFAdmaSkSa.DnYcptsvsegcphngsglyrst
                   ++a+++++   +GkG+YFA  aS+Sa D+Y+++ +      ng+++    
   mKIAA1268   923 SYAGKNATA--YGKGTYFAVKASYSAcDTYSRP-DT-----NGRKY---- 960  

                   lgmlLceVaLGdemneLtkadysaeklppgkhsvkGlGkttPawkdpses
                     m+  +V++G+                 ++ + + l  +++        
   mKIAA1268   961 --MYYVRVLTGN-----------------YTNGNASLIVPPS-------- 983  

                   fvdlDGvvvPlgklvstlydssvdntllynEYVVYdveQvrlkYLlevkf
                            +  +  ++lyd+++dn  ++ ++VV+ ++Q +++YL+++++
   mKIAA1268   984 --------RDPQNA-ADLYDTVTDNDKNPSIFVVFYDNQTYPEYLITFRQ 1024 

                   <-*
                      
   mKIAA1268     -     -    

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