hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/smart.HMMs Sequence file: /cdna4/rodent/full/goal/mbg/mbg11030/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1256 ( 1539 res) mbg11030 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- SH3 Src homology 3 domains 389.2 2.4e-112 5 RhoGEF Guanine nucleotide exchange factor for Rho/R 202.7 3.4e-56 1 EH Eps15 homology domain 157.8 1.1e-42 1 C2 Protein kinase C conserved region 2 (CalB) 78.7 7.1e-19 1 PH Pleckstrin homology domain. 47.8 1.5e-09 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- EH 1/1 119 214 .. 1 98 [] 157.8 1.1e-42 SH3 1/5 602 659 .. 1 58 [] 86.0 4.4e-21 SH3 2/5 736 790 .. 1 58 [] 74.3 1.5e-17 SH3 3/5 826 880 .. 1 58 [] 80.9 1.5e-19 SH3 4/5 898 958 .. 1 58 [] 60.2 2.7e-13 SH3 5/5 972 1027 .. 1 58 [] 91.2 1.2e-22 RhoGEF 1/1 1055 1236 .. 1 211 [] 202.7 3.4e-56 PH 1/1 1277 1388 .. 1 82 [] 47.8 1.5e-09 C2 1/1 1412 1509 .. 1 92 [] 78.7 7.1e-19 Alignments of top-scoring domains: EH: domain 1 of 1, from 119 to 214: score 157.8, E = 1.1e-42 *->eWaispedkakYdqiFrsldpdqdGtvsGaqakpiflkSgLPqtlLa eWa+++ + kY q F+sld++++G++sG qa++ +l+S+L+qt+La mKIAA1256 119 EWAVPQPSRLKYRQKFNSLDKGMSGYLSGFQARNALLQSNLSQTQLA 165 kIWaLaDidkdGeLdrePEFalAmhLiyrklnGgepiPasLPpelippsk +IW+LaDid+dG+L e EF+lAmhL +++++G +p+P +LPpel+pps+ mKIAA1256 166 TIWTLADIDGDGQLKAE-EFILAMHLTDMAKAG-QPLPLTLPPELVPPSF 213 r<-* r mKIAA1256 214 R 214 SH3: domain 1 of 5, from 602 to 659: score 86.0, E = 4.4e-21 *->eyvvAlYDyeaqnedELsFkkGDiitvleks..ddgWweGelnrtGk + ++AlY++ea+n+dE+sF+ GDii+v ek+ +++gW++G + Gk mKIAA1256 602 VNYRALYPFEARNHDEMSFSSGDIIQVDEKTvgEPGWLYGSFQ--GK 646 eGlfPsnYVeeie<-* G+fP+nYVe++ mKIAA1256 647 FGWFPCNYVEKVL 659 SH3: domain 2 of 5, from 736 to 790: score 74.3, E = 1.5e-17 *->eyvvAlYDyeaqnedELsFkkGDiitvleksddgWweGelnrtGkeG +++Al++++a e++L F+k D+itvle+ ++Ww Ge++ G +G mKIAA1256 736 LKAQALCSWTAKKENHLNFSKHDVITVLEQ-QENWWFGEVH--GGRG 779 lfPsnYVeeie<-* +fP++YV++i+ mKIAA1256 780 WFPKSYVKLIP 790 SH3: domain 3 of 5, from 826 to 880: score 80.9, E = 1.5e-19 *->eyvvAlYDyeaqnedELsFkkGDiitvleksddgWweGelnrtGkeG e ++AlY+y + ++++L+F++G+ i+v++k d++Ww G ++ ++G mKIAA1256 826 EDYIALYSYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIG--ERTG 869 lfPsnYVeeie<-* +fPsnYV++++ mKIAA1256 870 IFPSNYVRPKD 880 SH3: domain 4 of 5, from 898 to 958: score 60.2, E = 2.7e-13 *->eyvvAlYDyeaqnedELsFkkGDiitvleksddgWweGelnr...tG e +++ +y a++ + Ls+ +G+ i++l+k+ +gWw+Gel+ ++++ mKIAA1256 898 EIAQVTSAYAASGTEQLSLAPGQLILILKKNTSGWWQGELQArgkKR 944 keGlfPsnYVeeie<-* ++G+fP+++V+++ mKIAA1256 945 QKGWFPASHVKLLG 958 SH3: domain 5 of 5, from 972 to 1027: score 91.2, E = 1.2e-22 *->eyvvAlYDyeaqnedELsFkkGDiitvleksddgWweGelnrtGkeG ++v+A+YDy a nedEL F+kG+ i v +k+d++Ww+Ge n G +G mKIAA1256 972 CQVIAMYDYMANNEDELNFSKGQLINVMNKDDPDWWQGETN--GLTG 1016 lfPsnYVeeie<-* lfPsnYV+ + mKIAA1256 1017 LFPSNYVKMTT 1027 RhoGEF: domain 1 of 1, from 1055 to 1236: score 202.7, E = 3.4e-56 *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl ++EL+qTE+ Y +dL++++evf+k++ +++ +l++ ++ ++ mKIAA1256 1055 YIHELIQTEERYMDDLQLVIEVFQKRMAESG------FLTEADMALI 1095 FgpNieeiyefHrrFLdeLeerveewl.lskdlKsernsviedsgerigd F N+ e++ ++++L +L r +++ ++++ ++++igd mKIAA1256 1096 FV-NWKELIMSNTKLLRALRVR-KKTGgEKM------------PVQMIGD 1131 vFlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkeies ++ ++ ++++++Y+++cs + + ll++ k++++ +F++flk++ s mKIAA1256 1132 ILAAE---LSHMQAYIRFCSCQLNGATLLQQ--KTDEDTDFKEFLKKLAS 1176 kpncrsksearltLeslLikPvQRltkYpLLLkellkhtppdhedredLk +p+c +++L+s+L+kP+QR+t+YpLL++ +l +tp +h d+ Lk mKIAA1256 1177 DPRCK-----GMPLSSFLLKPMQRITRYPLLIRSILENTPQSHVDHSSLK 1221 kAleaikelasqvNe<-* Ale +el+sqvNe mKIAA1256 1222 LALERAEELCSQVNE 1236 PH: domain 1 of 1, from 1277 to 1388: score 47.8, E = 1.5e-09 *->vikeGwLlkkskswkkryfvLfn..gvLlyyksk............. ++++G L+k + s k+ +++Lfn+ L+y +++++ ++ mKIAA1256 1277 LLHSGKLYKTK-SNKELHAFLFNdfLLLTYLVRQfaaasgheklfns 1322 .......kpkgsipLsgcsvre.p.......cFeivt.drtlllqAesee +++ + + +k +i+L+++ v+ ++++++++++F i++ dr+++l++++ mKIAA1256 1323 kssaqfrMYKTPIFLNEVLVKLpTdpssdepVFHISHiDRVYTLRTDNIN 1372 ereeWvealqsaiaka<-* er+ Wv+ ++ a++++ mKIAA1256 1373 ERTAWVQKIKGASEQY 1388 C2: domain 1 of 1, from 1412 to 1509: score 78.7, E = 7.1e-19 *->tLtvkiisArnLp........DPYVkvs......kTkvvkktlsgfN +L+v++i+A L+ +++++++PY++vs ++++ T++ ++tl N mKIAA1256 1412 RLMVHVIEATELKackpngksNPYCEVSmgsqsyTTRTLQDTL---N 1455 PvWnEesetFeFevpp...s.LeieVyDk......dfiGrvtippnnahq P+Wn ++F + + ++ L+++ +D++ +++df+Gr+++p mKIAA1256 1456 PKWNF---NCQFFIKDlyqDvLCLTMFDRdqfspdDFLGRTEVP------ 1496 hsadglihlsell.ggrh.kl<-* + ++++++++++ mKIAA1256 1497 --------VAKIRtEQESkGP 1509 //