hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg11030/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1256 ( 1539 res) mbg11030 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- SH3_1 SH3 domain 310.7 1.8e-89 5 SH3_2 Variant SH3 domain 217.5 1.9e-61 5 RhoGEF RhoGEF domain 114.3 2.3e-30 1 C2 C2 domain 102.1 1.1e-26 1 PH PH domain 26.0 0.0009 1 efhand EF hand 22.7 0.0087 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- efhand 1/1 163 191 .. 1 29 [] 22.7 0.0087 SH3_2 1/5 603 658 .. 1 69 [] 26.2 0.00078 SH3_1 1/5 602 658 .. 1 58 [] 67.3 3.3e-16 SH3_2 2/5 737 789 .. 1 69 [] 61.6 1.7e-14 SH3_1 2/5 736 789 .. 1 58 [] 52.4 9.7e-12 SH3_2 3/5 827 879 .. 1 69 [] 39.5 7.7e-08 SH3_1 3/5 826 879 .. 1 58 [] 69.5 6.9e-17 SH3_1 4/5 898 957 .. 1 58 [] 45.8 9.3e-10 SH3_2 4/5 899 957 .. 1 69 [] 38.8 1.2e-07 SH3_2 5/5 973 1025 .. 1 69 [] 51.6 1.8e-11 SH3_1 5/5 972 1026 .. 1 58 [] 79.7 5.9e-20 RhoGEF 1/1 1055 1236 .. 1 207 [] 114.3 2.3e-30 PH 1/1 1277 1386 .. 1 92 [] 26.0 0.0009 C2 1/1 1413 1494 .. 1 88 [] 102.1 1.1e-26 Alignments of top-scoring domains: efhand: domain 1 of 1, from 163 to 191: score 22.7, E = 0.0087 *->elkeaFkefDkDgDGkIsfeEfkaalkkl<-* +l ++ ++D DgDG++ eEf+ a++ + mKIAA1256 163 QLATIWTLADIDGDGQLKAEEFILAMHLT 191 SH3_2: domain 1 of 5, from 603 to 658: score 26.2, E = 0.00078 *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskddd..gw +ra+ ++a ++ +e +s+ Gd++ v +k +++gw mKIAA1256 603 NYRALYPFEA-RNHDE------MSFSSGDIIQVD----EKTVGepGW 638 wlgeslggGrrrRGlvPssaveel<-* +g+ G+ G++P ++ve++ mKIAA1256 639 LYGSF--QGKF--GWFPCNYVEKV 658 SH3_1: domain 1 of 5, from 602 to 658: score 67.3, E = 3.3e-16 *->kkvvALYDYearesdELsFkkGDvitvleksdd..gWWkgrlkgtgG ++ALY++ear+ dE+sF GD+i+v ek+ +++gW++g + G mKIAA1256 602 VNYRALYPFEARNHDEMSFSSGDIIQVDEKTVGepGWLYGSFQ---G 645 keGliPsNYVepv<-* k+G++P+NYVe+v mKIAA1256 646 KFGWFPCNYVEKV 658 SH3_2: domain 2 of 5, from 737 to 789: score 61.6, E = 1.7e-14 *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskdddgwwl +++a+++++a ++n+ L++ k+dv+ v+ + +++ww+ mKIAA1256 737 KAQALCSWTA-KKENH------LNFSKHDVITVL-----EQQENWWF 771 geslggGrrrRGlvPssaveel<-* ge+ +G r G++P s+v+ + mKIAA1256 772 GEV--HGGR--GWFPKSYVKLI 789 SH3_1: domain 2 of 5, from 736 to 789: score 52.4, E = 9.7e-12 *->kkvvALYDYearesdELsFkkGDvitvleksddgWWkgrlkgtgGke k++AL +a +++L F k Dvitvle++++ WW+g+++ G + mKIAA1256 736 LKAQALCSWTAKKENHLNFSKHDVITVLEQQEN-WWFGEVH---GGR 778 GliPsNYVepv<-* G++P +YV ++ mKIAA1256 779 GWFPKSYVKLI 789 SH3_2: domain 3 of 5, from 827 to 879: score 39.5, E = 7.7e-08 *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskdddgwwl ++a+ +y + +++ L++++G+ + v+ ++d++ww mKIAA1256 827 DYIALYSYSS-VEPGD------LTFTEGEEILVT-----QKDGEWWT 861 geslggGrrrRGlvPssaveel<-* g+ g r+ G +Ps++v++ mKIAA1256 862 GSI--GERT--GIFPSNYVRPK 879 SH3_1: domain 3 of 5, from 826 to 879: score 69.5, E = 6.9e-17 *->kkvvALYDYearesdELsFkkGDvitvleksddgWWkgrlkgtgGke + ++ALY Y +e+++L+F++G++i v +k+ ++WW+g ++ mKIAA1256 826 EDYIALYSYSSVEPGDLTFTEGEEILVTQKD-GEWWTGSIGE---RT 868 GliPsNYVepv<-* G++PsNYV+p+ mKIAA1256 869 GIFPSNYVRPK 879 SH3_1: domain 4 of 5, from 898 to 957: score 45.8, E = 9.3e-10 *->kkvvALYDYearesdELsFkkGDvitvleksddgWWkgrlkgtgG.. +++++ +Y+a++ + Ls+ +G i +l+k+ +gWW g+l+ + G++ mKIAA1256 898 EIAQVTSAYAASGTEQLSLAPGQLILILKKNTSGWWQGELQAR-Gkk 943 .keGliPsNYVepv<-* +++G++P++ V + mKIAA1256 944 rQKGWFPASHVKLL 957 SH3_2: domain 4 of 5, from 899 to 957: score 38.8, E = 1.2e-07 *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskdddgwwl ++++ y a ++++ Lsl G+++ ++ +k+ gww+ mKIAA1256 899 IAQVTSAYAA-SGTEQ------LSLAPGQLILIL----KKNTSGWWQ 934 geslggGrrr.RGlvPssaveel<-* ge+ +G++r+ G++P+s+v+ l mKIAA1256 935 GELQARGKKRqKGWFPASHVKLL 957 SH3_2: domain 5 of 5, from 973 to 1025: score 51.6, E = 1.8e-11 *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskdddgwwl ++a+ dy a ++++e L++ kG+++ v +kdd++ww+ mKIAA1256 973 QVIAMYDYMA-NNEDE------LNFSKGQLINVM----NKDDPDWWQ 1008 geslggGrrrRGlvPssaveel<-* ge+ +G + Gl+Ps++v ++ mKIAA1256 1009 GET--NGLT--GLFPSNYV-KM 1025 SH3_1: domain 5 of 5, from 972 to 1026: score 79.7, E = 5.9e-20 *->kkvvALYDYearesdELsFkkGDvitvleksddgWWkgrlkgtgGke +v+A YDY+a+++dEL F kG i v +k+d +WW g+ + G + mKIAA1256 972 CQVIAMYDYMANNEDELNFSKGQLINVMNKDDPDWWQGETN---GLT 1015 GliPsNYVepv<-* Gl+PsNYV + mKIAA1256 1016 GLFPSNYVKMT 1026 RhoGEF: domain 1 of 1, from 1055 to 1236: score 114.3, E = 2.3e-30 *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF + El++TE+ Y +dL +++ v+ k++ e+ +lt d+ iF mKIAA1256 1055 YIHELIQTEERYMDDLQLVIEVFQKRMAESG-----FLTEADMALIF 1096 sNiediyefhreFLkssLear....isssqfedlDekkiepsaqrlGdlF N +++ ++ +L+ +L r++++ + + q +Gd++ mKIAA1256 1097 VNWKELIMSNTKLLR-ALRVRkktgGEKM------------PVQMIGDIL 1133 lklkepflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassnt + ++++ q Y ++cs + + +ll + + ++F+efl+++ + + mKIAA1256 1134 AAELSHM-QAYIRFCSCQLNGATLLQQ--KTDEDTDFKEFLKKLASDPRC 1180 gAkddavkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkk L+s+LlkP+qRi+rYpLL++ +L tp ++ d+ +Lk+ mKIAA1256 1181 K------GMPLSSFLLKPMQRITRYPLLIRSILENTPQ--SHVDHSSLKL 1222 aldllqdlaksiNe<-* al+ ++l +++Ne mKIAA1256 1223 ALERAEELCSQVNE 1236 PH: domain 1 of 1, from 1277 to 1386: score 26.0, E = 0.0009 *->vikeGwLlkkggkkswkkRyfvLfndvLlyykdkk............ + ++G L+k s k+ +++Lfnd Ll+ + +++++ mKIAA1256 1277 LLHSGKLYKTK---SNKELHAFLFNDFLLLTYLVRqfaaasgheklf 1320 ........kkpkgsipLsgiqvekvpdn.krkncFeirt.dretlllqae +++++ + +k i L+++ v+ ++d++ ++ +F i++ dr +++l+++ mKIAA1256 1321 nskssaqfRMYKTPIFLNEVLVKLPTDPsSDEPVFHISHiDR-VYTLRTD 1369 seeerkeWvkaiqsair<-* + er+ Wv+ i+ a++ mKIAA1256 1370 NINERTAWVQKIKGASE 1386 C2: domain 1 of 1, from 1413 to 1494: score 102.1, E = 1.1e-26 *->LrVtvieAknLppkDfkngksDPYVkvslggdkkdqkkkTkvikktl L V+vieA L+++ +ngks+PY++vs+g q + T++ +tl mKIAA1256 1413 LMVHVIEATELKACK-PNGKSNPYCEVSMGS----QSYTTRTLQDTL 1454 NPvWNEtFtFevpppdlqe.tLeieVyDydrfgrddflGevs<-* NP+WN ++F dl +++L ++ +D+d f+ ddflG+++ mKIAA1256 1455 NPKWNFNCQFF--IKDLYQdVLCLTMFDRDQFSPDDFLGRTE 1494 //