hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg09359/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1249 ( 1079 res) mbg09359 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- ArfGap Putative GTPase activating protein for Arf 137.7 2.1e-37 1 PH PH domain 63.5 4.5e-15 1 SH3_1 SH3 domain 48.8 1.2e-10 1 Ank Ankyrin repeat 47.6 2.8e-10 2 SH3_2 Variant SH3 domain 33.4 5.2e-06 1 Extensin_2 Extensin-like region -130.9 0.22 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- PH 1/1 272 363 .. 1 92 [] 63.5 4.5e-15 ArfGap 1/1 386 509 .. 1 137 [] 137.7 2.1e-37 Ank 1/2 547 582 .. 1 33 [] 24.2 0.0031 Ank 2/2 583 615 .. 1 33 [] 23.4 0.0054 Extensin_2 1/1 623 945 .. 1 385 [] -130.9 0.22 SH3_1 1/1 1020 1077 .. 1 58 [] 48.8 1.2e-10 SH3_2 1/1 1021 1077 .. 1 69 [] 33.4 5.2e-06 Alignments of top-scoring domains: PH: domain 1 of 1, from 272 to 363: score 63.5, E = 4.5e-15 *->vikeGwLlkkg..gkkswkkRyfvLfndvLlyykdkkkkpkgsipLs +k+G+Llkk+++ +k w++R + ++n+ L + + + +++L mKIAA1249 272 SEKKGFLLKKSdgIRKVWQRRKCAVKNGILTISHATSNRQPAKLNLL 318 giqvekvpdnkrkncFeirt.dretlllqaeseeerkeWvkaiqsair<- ++qv++ + +k +F +++++r t+++qae+e++ W++ + ++ + mKIAA1249 319 TCQVKPNAE--DKKSFDLIShNR-TYHFQAEDEQDYIAWISVLTNSKE 363 * mKIAA1249 - - ArfGap: domain 1 of 1, from 386 to 509: score 137.7, E = 2.1e-37 *->qrvlqlLrsldpgNkkCfDCgavpnPtWaSvnlGvflCieCSGiHRn ++ ++++++l+ gN C+DCg+ +PtW S nlG++ CieCSGiHR mKIAA1249 386 KAIIEDVQRLP-GNDICCDCGS-SEPTWLSTNLGILTCIECSGIHRE 430 LfGvHiSkVnvRSltLDsWtpeeLrklesckgGNenansfwEsnlddfsl + GvHiS++ Sl LD+ eL + + + GN+ +n + E+nl+ +s mKIAA1249 431 M-GVHISRI--QSLELDKLGTSELLLAK--NVGNNSFNDIMEANLPSPSP 475 kpkdsdaaavKCqddrqkyesfiaaKYeeklf..vlkeeqee<-* kp++s+ d +++++i aKY++++f++ + ++++ mKIAA1249 476 KPTPSS--------DMTVRKEYITAKYVDHRFsrKTCASSSA 509 Ank: domain 1 of 2, from 547 to 582: score 24.2, E = 0.0031 *->dGfTPLHlAalrg...nlevvklLlsqGAdlnaqdd<-* G+T+LHlA++ + +l +v +L+++ +l+ q+ mKIAA1249 547 LGETALHLAVRTAdqtSLHLVDFLVQNCGNLDKQTS 582 Ank: domain 2 of 2, from 583 to 615: score 23.4, E = 0.0054 *->dGfTPLHlAalrgnlevvklLlsqGAdlnaqdd<-* G+T LH+ +++g +e++klLl +++++ mKIAA1249 583 VGNTVLHYCSMYGKPECLKLLLRSKPTVDIVNQ 615 Extensin_2: domain 1 of 1, from 623 to 945: score -130.9, E = 0.22 *->lltlvvalvslslpseasakYsYsSPPPpekpY.............. +++ + a l s+a+ s + P + Y+ + ++++ +++++ mKIAA1249 623 IAKRLKATQCEDLLSQAK---SGKFNPHVHVEYewnlrqdemdesdd 666 vYkSPPpPspkyvykSPPPpkkpYvYsSPPPPsyvykSPPPPkpyvYkSP P P+ ++SP P + sS P + P S mKIAA1249 667 DLDDKPSPIK--KERSPRPQ--SFCHSSSISP-QDKLALPGF------ST 705 PpP..kyvYkSPPpPvykYkSPPPPthsppPpyvykSPPPPpk..kyvyk P+ +++ Y ++ S Pt + + PP Pp++ mKIAA1249 706 PRDkqRLSYGAFTNQIFASTSTDLPT-----SPTSEAPPLPPRnaGKGPT 750 SpPpptPvYkYkSPPPPpyvYkspPpPvkkripyvYkSPPPPpPYvYkSp pP P S k pPpP + ++ + PP P P mKIAA1249 751 GPPSTLPLGTQTSSGSSTLSKKRPPPPPPG-HKRTLSDPPSPLP----HG 795 PppvkkyiyksppppephkYvYkSPPPPpPYvyesvpeqkikYvYkSPPP Pp + + p ++ P+ s + k+ S mKIAA1249 796 PPNK------GAIPWGND-------VGPS-----SSSKTANKFEGLSQQA 827 PkksYkspsppkyVYkSpPpPvipykYkSPPPPkkkyspaPrkpyvYkSP + s k p+ k p v + ++ + mKIAA1249 828 STSSAKTALGPRVLPKLPQK-V-----------ALRKTETSHHLSLDRTN 865 PPPtyvYkSpPpPykpptppkiyksPPPPtPvyvYkspPpippikssspp PP kS + p+ p++ + PP P + +P+ mKIAA1249 866 IPPETFQKSSQLTE-LPQKPPLGELPPKPV-----ELAPK---------- 899 PvyvYkSpPppvysPPPPyvYssPPPPvyvynsaPvykksPPkhhYiYsS + v + pP+p + PP P + PP P + P+++ + mKIAA1249 900 -PQVGELPPKPGELPPKPQLGDLPPKPQ---------LSDLPPKPQMKDL 939 PPPphh<-* PP p mKIAA1249 940 PPKPQL 945 SH3_1: domain 1 of 1, from 1020 to 1077: score 48.8, E = 1.2e-10 *->kkvvALYDYearesdELsFkkGDvitvleksddgWWkgrlkgtgG.. ++v+ +YD +a ++dEL+F +G+vi+v ++d +WW g G++ mKIAA1249 1020 RRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWIGHIE---Gqp 1063 .keGliPsNYVepv<-* +++G +P+++V mKIAA1249 1064 eRKGVFPVSFVHIL 1077 SH3_2: domain 1 of 1, from 1021 to 1077: score 33.4, E = 5.2e-06 *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskdddgwwl ++++i d+ a + +e L++ +G+v+ v+ +++d +ww mKIAA1249 1021 RVKTIYDCQA-DNDDE------LTFIEGEVIIVT----GEEDQEWWI 1056 g.eslgg..GrrrRGlvPssaveel<-* g+ + g++ r+ G++P s+v +l mKIAA1249 1057 GhIE--GqpERK--GVFPVSFVHIL 1077 //