hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbj/mbj01002/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1246  ( 833 res)   mbj01002

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
LRR_1    Leucine Rich Repeat                             67.0    4.1e-16   7
I-set    Immunoglobulin I-set domain                     65.2    1.4e-15   1
ig       Immunoglobulin domain                           32.2    1.2e-05   1
fn3      Fibronectin type III domain                     25.2     0.0016   1
V-set    Immunoglobulin V-set domain                      6.6       0.13   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
LRR_1      1/7      98   121 ..     1    25 []     8.0       96
LRR_1      2/7     122   143 ..     1    25 []     8.9       66
LRR_1      3/7     146   169 ..     1    25 []    12.8      8.5
LRR_1      4/7     170   193 ..     1    25 []    14.5      2.5
LRR_1      5/7     195   218 ..     1    25 []    11.5       20
LRR_1      6/7     219   242 ..     1    25 []    13.7      4.3
LRR_1      7/7     243   266 ..     1    25 []    10.9       32
ig         1/1     348   406 ..     1    65 []    32.2  1.2e-05
V-set      1/1     333   420 ..     1   130 []     6.6     0.13
I-set      1/1     334   422 ..     1    97 []    65.2  1.4e-15
fn3        1/1     463   545 ..     1    84 []    25.2   0.0016

Alignments of top-scoring domains:
LRR_1: domain 1 of 7, from 98 to 121: score 8.0, E = 96
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +  eL+L+g N  +  ++   ++ +++   
   mKIAA1246    98    RTVELRLGG-N-FII-HIGRQdFaNMT    121  

LRR_1: domain 2 of 7, from 122 to 143: score 8.9, E = 66
                   *->nLeeLdLsgCNpslsgslppsl.glp<-*
                       L  L Ls+ N  +s +++p ++ l    
   mKIAA1246   122    GLVDLTLSR-N-TIS-HIQP-FsFLD    143  

LRR_1: domain 3 of 7, from 146 to 169: score 12.8, E = 8.5
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L++L+L++ N +l +sl +++l+gl    
   mKIAA1246   146    SLRSLHLDS-N-RL-PSLGEDtLrGLV    169  

LRR_1: domain 4 of 7, from 170 to 193: score 14.5, E = 2.5
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      nL++L +++ N +l g +++++++++    
   mKIAA1246   170    NLQHLIVNN-N-QL-GGIADDaFeDFL    193  

LRR_1: domain 5 of 7, from 195 to 218: score 11.5, E = 20
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +Le LdLs+ N +l   lp ++ + +    
   mKIAA1246   195    TLEDLDLSY-N-NLH-GLPWDsVrRMV    218  

LRR_1: domain 6 of 7, from 219 to 242: score 13.7, E = 4.3
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      nL  L+L++ N  l ++++++++ +l+   
   mKIAA1246   219    NLHQLSLDH-N-LL-DHIAEGtFaDLQ    242  

LRR_1: domain 7 of 7, from 243 to 266: score 10.9, E = 32
                   *->nLeeLdLsgCNpslsgslpps.l.glp<-*
                      +L  LdL + N +l+  lpp+++   +   
   mKIAA1246   243    KLARLDLTS-N-RLQ-KLPPDpIfARS    266  

ig: domain 1 of 1, from 348 to 406: score 32.2, E = 1.2e-05
                   *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq
                      G+ +tL C +   g+p++ ++W   + +l +  + t + +ng+    
   mKIAA1246   348    GQAATLKCKA--IGDPSPLIHWVAPDDrLVgNSSRTAVYDNGT---- 388  

                   tsLtitnvtpeDggtYtCvv<-*
                     L i+ +t++D+g +tC +   
   mKIAA1246   389 --LDILITTSQDSGPFTCIA    406  

V-set: domain 1 of 1, from 333 to 420: score 6.6, E = 0.13
                   *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss
                      +  +tq + +           + v eG+ +tL+C+     +d+    
   mKIAA1246   333    PPLITQ-HTH----------KLLVLEGQAATLKCKAI---GDP---- 361  

                   gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn
                   ++  ++W+   +              + + +          + r+ ++ n
   mKIAA1246   362 SP-LIHWVA-PDD-------------RLVGN----------SSRTAVYDN 386  

                   pskgdfsLtIsnlqlsDsGtYyCa......gggtrLtVl<-*
                   ++     L I   ++ DsG  +C   +  ++   ++ V+   
   mKIAA1246   387 GT-----LDILITTSQDSGPFTCIaanaagEATATVEVS    420  

I-set: domain 1 of 1, from 334 to 422: score 65.2, E = 1.4e-15
                   *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKd.Gqplssvll
                      P +tq+ + + V eG++a++ Ck++G+P P + W   +++ + +   
   mKIAA1246   334    PLITQHTHKLLVLEGQAATLKCKAIGDPSPLIHWVAPdDRLVGN--- 377  

                   psdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV
                    s+r  v  +g     tL I+  ++ DsG  tC+A N aGea+a++e+ +
   mKIAA1246   378 -SSRTAVYDNG-----TLDILITTSQDSGPFTCIAANAAGEATATVEVSI 421  

                   q<-*
                       
   mKIAA1246   422 V    422  

fn3: domain 1 of 1, from 463 to 545: score 25.2, E = 0.0016
                   *->P.saP.tnltvtdvtstsltlsWspptgngpitgYevtyRqpkngge
                      P+s P++ + v+dvt+ts+ + Ws ++    +  Y+++y +++++  
   mKIAA1246   463    PkSTPeRAVLVSDVTTTSALVKWSVSKSAPRVKMYQLQYNCSDDEV- 508  

                   wneltvpgtttsytltgLkPgteYevrVqAvnggGGpeS<-*
                      +++p +   +++++L+ gt Y ++V A  ++    +   
   mKIAA1246   509 LIYRMIPASNKAFVVNNLVSGTGYDLCVLAMWDD--TAT    545  

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