hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05359/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1232  ( 950 res)   mbg05359

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
GuKc     Guanylate kinase homologues.                   266.6    1.9e-75   1
PDZ      Domain present in PSD-95, Dlg, and ZO-1/2.     263.8    1.4e-74   3
SH3      Src homology 3 domains                          53.0    3.8e-11   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
PDZ        1/3     272   351 ..     1    80 []    84.9  9.8e-21
PDZ        2/3     367   446 ..     1    80 []    93.3  2.8e-23
PDZ        3/3     527   600 ..     1    80 []    98.4  8.4e-25
SH3        1/1     637   703 ..     1    58 []    53.0  3.8e-11
GuKc       1/1     759   938 ..     1   203 []   266.6  1.9e-75

Alignments of top-scoring domains:
PDZ: domain 1 of 3, from 272 to 351: score 84.9, E = 9.8e-21
                   *->gglGfsivg...........gifvssvvpGspAakaGrkslglLkvG
                       glGfsi+g+ ++++ ++++gif+++++pG++Aa +Gr     L v+
   mKIAA1232   272    SGLGFSIAGgidnphvpddpGIFITKIIPGGAAAMDGR-----LGVN 313  

                   DvIleVNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   D +l+VN  ++v+ + h +av++lk+ag+     +v+L+v+R+    
   mKIAA1232   314 DCVLRVNE-VDVSEVVHSRAVEALKEAGP-----VVRLVVRRRQ    351  

PDZ: domain 2 of 3, from 367 to 446: score 93.3, E = 2.8e-23
                   *->gglGfsivg...........gifvssvvpGspAakaGrkslglLkvG
                      +glGfsi+g+ ++++ ++++ i+++++++G++A k+Gr     L++G
   mKIAA1232   367    KGLGFSIAGgignqhipgdnSIYITKIIEGGAAQKDGR-----LQIG 408  

                   DvIleVNGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   D++l+VN+ t++++++heeav+ lk++++      v L+v ++g   
   mKIAA1232   409 DRLLAVNN-TNLQDVRHEEAVASLKNTSD-----MVYLKVAKPG    446  

PDZ: domain 3 of 3, from 527 to 600: score 98.4, E = 8.4e-25
                   *->gglGfsivg.....gifvssvvpGspAakaGrkslglLkvGDvIleV
                       glGf+ivg+++++gifvs +++G+pA+ +G      L+ GD+Il+V
   mKIAA1232   527    TGLGFNIVGgedgeGIFVSFILAGGPADLSGE-----LRRGDRILSV 568  

                   NGetsvegltheeavdllkkaggggvGekvtLtvlRgg<-*
                   NG ++++++the+a+++lk+ag+     +vt++ ++++   
   mKIAA1232   569 NG-VNLRNATHEQAAAALKRAGQ-----SVTIVAQYRP    600  

SH3: domain 1 of 1, from 637 to 703: score 53.0, E = 3.8e-11
                   *->eyvvAlYDyea.....qnedELsFkkGDiitvleksddgWweGelnr
                       yv+Al+Dy+ ++++   ++ LsF+ GDi++v++ sdd+Ww+++l +
   mKIAA1232   637    LYVRALFDYDRtrdscLPSQGLSFSYGDILHVINASDDEWWQARLVT 683  

                   ....tGkeGlfPsnYVeeie<-*
                   +++++ ++G +Ps    e++   
   mKIAA1232   684 phgeSEQIGVIPSKKRVEKK    703  

GuKc: domain 1 of 1, from 759 to 938: score 266.6, E = 1.9e-75
                   *->drRpivLsGpsGvGKstlkakLlqeyPdypkfgfsVshTTRppRpgE
                      + Rp++++Gp    K++++++L++e+P+  kfg +V+hTTRp+R  E
   mKIAA1232   759    YARPVIILGP---MKDRVNDDLISEFPH--KFGSCVPHTTRPRRDNE 800  

                   vnGPvvDYhFvsLkeefeqdiksgkflEwgeysgnlyYGTskesvrqvae
                   v+G  +DYhFv ++e++e+di+++kf+E g++++n +YGTs++svr+vae
   mKIAA1232   801 VDG--QDYHFVVSREQMEKDIQDNKFIEAGQFNDN-LYGTSIQSVRAVAE 847  

                   kGKhclLDidpqgvkqlkkarRkselnpiviFIapPsleeleerlrgaeq
                   +GKhc+LD++ +++k+l++a    +l+pi iFI+p+s+e l+e++r    
   mKIAA1232   848 RGKHCILDVSGNAIKRLQQA----QLYPIAIFIKPKSIEALMEMNRR--- 890  

                   RgteteeriqkrlaaaaqkeaqeyskeahlFdlvivnddledayYkeLke
                    + e++++i ++++   ++e++ey      F++++++d+le++y  ++k+
   mKIAA1232   891 QTYEQANKIFDKAMK-LEQEFGEY------FTAIVQGDSLEEIY-NKIKQ 932  

                   ileaeq<-*
                   i+e++    
   mKIAA1232   933 IIEDQS    938  

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