hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05359/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1232  ( 950 res)   mbg05359

Scores for sequence family classification (score includes all domains):
Model         Description                               Score    E-value  N 
--------      -----------                               -----    ------- ---
PDZ           PDZ domain (Also known as DHR or GLGF)    272.1    7.3e-78   3
Guanylate_kin Guanylate kinase                          184.8    1.4e-51   1
SH3_2         Variant SH3 domain                         28.9    0.00012   1
SH3_1         SH3 domain                                 28.1    0.00021   1

Parsed for domains:
Model         Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------      ------- ----- -----    ----- -----      -----  -------
PDZ             1/3     264   348 ..     1    82 []    87.9  2.1e-22
PDZ             2/3     359   443 ..     1    82 []    95.0  1.5e-24
PDZ             3/3     519   597 ..     1    82 []   103.2    5e-27
SH3_2           1/1     638   702 ..     1    69 []    28.9  0.00012
SH3_1           1/1     637   703 ..     1    58 []    28.1  0.00021
Guanylate_kin   1/1     793   895 ..     1   107 []   184.8  1.4e-51

Alignments of top-scoring domains:
PDZ: domain 1 of 3, from 264 to 348: score 87.9, E = 2.1e-22
                   *->evtlekevkrgglGfsikggsdk.......givvsevlpGsgaAeag
                      e++le+  +++glGfsi+gg d+++ ++++gi++++++pG gaA+ +
   mKIAA1232   264    EIVLER--GNSGLGFSIAGGIDNphvpddpGIFITKIIPG-GAAAMD 307  

                   GrLkeGDqIlsvNGqdvenlsheravlalkgsggsevtLtil<-*
                   GrL ++D +l vN +dv+ + h rav+alk++g  +v+L+++   
   mKIAA1232   308 GRLGVNDCVLRVNEVDVSEVVHSRAVEALKEAGP-VVRLVVR    348  

PDZ: domain 2 of 3, from 359 to 443: score 95.0, E = 1.5e-24
                   *->evtlekevkrgglGfsikggsdk.......givvsevlpGsgaAeag
                      ev l k  ++ glGfsi+gg  +++ +++++i+++++++G gaA+++
   mKIAA1232   359    EVNLLK--GPKGLGFSIAGGIGNqhipgdnSIYITKIIEG-GAAQKD 402  

                   GrLkeGDqIlsvNGqdvenlsheravlalkgsggsevtLtil<-*
                   GrL++GD++l+vN++++ +++he+av+ lk++++  v L+++   
   mKIAA1232   403 GRLQIGDRLLAVNNTNLQDVRHEEAVASLKNTSD-MVYLKVA    443  

PDZ: domain 3 of 3, from 519 to 597: score 103.2, E = 5e-27
                   *->evtlekevkrgglGfsikggsdk.givvsevlpGsgaAeagGrLkeG
                      +++l+k  +  glGf+i+gg+d++gi+vs +l+G g+A+ +G+L+ G
   mKIAA1232   519    KIILHK--GSTGLGFNIVGGEDGeGIFVSFILAG-GPADLSGELRRG 562  

                   DqIlsvNGqdvenlsheravlalkgsggsevtLtil<-*
                   D+IlsvNG++++n +he+a++alk++g+ +vt++ +   
   mKIAA1232   563 DRILSVNGVNLRNATHEQAAAALKRAGQ-SVTIVAQ    597  

SH3_2: domain 1 of 1, from 638 to 702: score 28.9, E = 0.00012
                   *->ygraiedyva.AtdknenleeeeLslkkGdvvkvidvggskdddgww
                      y+ra++dy+ +  ++ +   +  Ls+  Gd+++vi    + +dd+ww
   mKIAA1232   638    YVRALFDYDRtRDSCLP---SQGLSFSYGDILHVI----NASDDEWW 677  

                   lgeslgg.....GrrrRGlvPssaveel<-*
                   ++++   +++++ +   G++Ps+ + e    
   mKIAA1232   678 QARL-VTphgesEQI--GVIPSKKRVEK    702  

SH3_1: domain 1 of 1, from 637 to 703: score 28.1, E = 0.00021
                   *->kkvvALYDYeare.....sdELsFkkGDvitvleksddgWWkgrlkg
                       +v+AL+DY+ + ++  +s+ LsF  GD+++v++ sdd+WW +rl +
   mKIAA1232   637    LYVRALFDYDRTRdsclpSQGLSFSYGDILHVINASDDEWWQARLVT 683  

                   tgG...keGliPs.NYVepv<-*
                    +G++++ G iPs+  Ve++   
   mKIAA1232   684 PHGeseQIGVIPSkKRVEKK    703  

Guanylate_kin: domain 1 of 1, from 793 to 895: score 184.8, E = 1.4e-51
                   *->TRpPRpgEvdGkDYhFVsSrEemekdIsaneFLEyaefnGNyYGTsk
                      TRp R  EvdG DYhFV SrE+mekdI+ n+F+E+++fn+N+YGTs 
   mKIAA1232   793    TRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSI 839  

                   eaVrqvaksGkiciLDvepQGvkqlrtaelsNPvsvFIaPpSlqelekrL
                   ++Vr+va+ Gk+ciLDv+ +++k+l++a+l+ P+++FI+P+S    e  +
   mKIAA1232   840 QSVRAVAERGKHCILDVSGNAIKRLQQAQLY-PIAIFIKPKS---IEALM 885  

                   rgrnketEEs<-*
                   +++++ t E+   
   mKIAA1232   886 EMNRRQTYEQ    895  

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