hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj00035/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1230  ( 990 res)   mfj00035

Scores for sequence family classification (score includes all domains):
Model         Description                               Score    E-value  N 
--------      -----------                               -----    ------- ---
SAM_1         SAM domain (Sterile alpha motif)          138.8    9.4e-38   2
SAM_2         SAM domain (Sterile alpha motif)          113.4    4.3e-30   3
Integrase_DNA DNA binding domain of tn916 integrase      19.0      0.052   1
GBP_C         Guanylate-binding protein, C-terminal d  -145.0       0.26   1

Parsed for domains:
Model         Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------      ------- ----- -----    ----- -----      -----  -------
GBP_C           1/1       5   221 ..     1   305 []  -145.0     0.26
Integrase_DNA   1/1     197   261 ..     1    67 []    19.0    0.052
SAM_1           1/2     625   689 ..     1    66 []    66.7    5e-16
SAM_2           1/3     624   691 ..     1    72 []    20.1    0.054
SAM_1           2/2     697   760 ..     1    66 []    78.0    2e-19
SAM_2           2/3     696   762 ..     1    72 []    32.1  1.3e-05
SAM_2           3/3     784   856 ..     1    72 []    65.7  9.7e-16

Alignments of top-scoring domains:
GBP_C: domain 1 of 1, from 5 to 221: score -145.0, E = 0.26
                   *->GGiiVTGprLatLVqtYvnAInSGsVPClesavtTLAQiENsaAVqk
                              +L +  ++ ++  +       + +  +L+Q  + +A  k
   mKIAA1230     5    --------PLTS--KKMMSDAS-------DMLAAALEQMDGIIAGSK 34   

                   AiahYeeqMeQrleLPTetlQeLLdvHrdCEkEAlavFmenSFkNVDvkQ
                   A + Y+ +     + PT                    Fm +  +      
   mKIAA1230    35 ALE-YSNGIFD-CQSPTSP------------------FMGSLRA------ 58   

                   kFqrkLvaqLeaakedFcrkNeeaSssrCq...alLedLskdLeelikqG
                        Lv+ L+  +e       e    rCq ++   e L + L  +    
   mKIAA1230    59 ---LHLVEDLRGLLE--MMETDEKEGLRCQipdSTAEVLIEWLQNQMTN- 102  

                   dfsvpGGhrLfleavqeieakYkQvPrKGvkAsevLkefLqDILVHsked
                       pG    + e+++++e++         k s vL+ ++          
   mKIAA1230   103 -GHLPGNGDVYQERLARLEND---------KESLVLQVSVL--------- 133  

                   laDsLlqtdqaLtlkekaiEaerNikkEaAEkaekllrEkQKrhEeamEa
                     D   +   +  + e  +E+ r    E + + e++l +           
   mKIAA1230   134 -TDQVEAQGEKIRDLEFCLEEHR----EKLNATEEMLQQ----------- 167  

                   kEksyqEhkkqLtekmEserkqLmaEqnrm.LEhklkeqeeLleeGFkne
                         E + +    +E  + +LmaE ++++L +   e+ +L  e + + 
   mKIAA1230   168 ------ELLSRTS--LETQKLELMAEISNLkLKLTAVEKDRLDYEDRFRD 209  

                   stllekeIselr<-*
                    + l +eI +lr   
   mKIAA1230   210 TEGLIQEINDLR    221  

Integrase_DNA: domain 1 of 1, from 197 to 261: score 19.0, E = 0.052
                   *->EkrrdekervlrkgEsqrkdlRYlykyvdelgeprFvYsWKLvatda
                      Ek r   e   r  E + +++  l  +v e+  +r +Y+ KL+ t+ 
   mKIAA1230   197    EKDRLDYEDRFRDTEGLIQEINDLRLKVNEMDGERLQYEKKLKSTKD 243  

                   epagkreciaLRekdkEIqK<-*
                   e a ++e+  L ek+ E+++   
   mKIAA1230   244 ELASLKEQ--LEEKECEVKR    261  

SAM_1: domain 1 of 2, from 625 to 689: score 66.7, E = 5e-16
                   *->dgwsvesVgeWLesigllgqYidnFlaagyidgdtllqlteeDLed.
                        w+ e+V+ WL + gl g Y ++  +++ i+g+tllq +++DLe++
   mKIAA1230   625    AKWTKEQVCSWLAEQGL-GSYLSSG-KHWIISGQTLLQASQQDLEKe 669  

                   lGvtllGHrkkIlssIqgLk<-*
                   lG+++  Hrkk+++++q L    
   mKIAA1230   670 LGIKHSLHRKKLQLALQALG    689  

SAM_2: domain 1 of 3, from 624 to 691: score 20.1, E = 0.054
                   *->veswslesvaeWLesiglegqYkdnFsdqgitglellllrlteedLa
                         w+ e+v++WL + gl g Y  + +   i+g + l l+ +++dL 
   mKIAA1230   624    FAKWTKEQVCSWLAEQGL-GSYLSSGKHWIISG-QTL-LQASQQDL- 666  

                   klalGitsvghRkkilskiqelkqq<-*
                   + +lGi    hRkk+  ++q l  +   
   mKIAA1230   667 EKELGIKHSLHRKKLQLALQALGSE    691  

SAM_1: domain 2 of 2, from 697 to 760: score 78.0, E = 2e-19
                   *->dgwsvesVgeWLesigllgqYidnFlaagyidgdtllqlteeDLedl
                      +  +++ V +WL++igl +qY+ +F   g++dg++l  +t +DL++l
   mKIAA1230   697    GKLDFNWVTRWLDDIGL-PQYKTQF-DEGRVDGRMLHYMTVDDLLSL 741  

                   GvtllGHrkkIlssIqgLk<-*
                   +v+++ H + I ++Iq L+   
   mKIAA1230   742 KVVSVLHHLSIKRAIQVLR    760  

SAM_2: domain 2 of 3, from 696 to 762: score 32.1, E = 1.3e-05
                   *->veswslesvaeWLesiglegqYkdnFsdqgitglellllrlteedLa
                      +   +++ v+ WL+ igl +qYk  F +  ++g ++l +++t +dL 
   mKIAA1230   696    YGKLDFNWVTRWLDDIGL-PQYKTQFDEGRVDG-RML-HYMTVDDL- 738  

                   klalGitsvghRkkilskiqelkqq<-*
                   +  l++ sv h + i ++iq l+     
   mKIAA1230   739 L-SLKVVSVLHHLSIKRAIQVLRIN    762  

SAM_2: domain 3 of 3, from 784 to 856: score 65.7, E = 9.7e-16
                   *->veswslesvaeWLesiglegqYkdnFsdqgitglelll.lrlteedL
                      v +w++++v+eWL+s++l ++Y++n+++ g++g+ ++l++r++ e++
   mKIAA1230   784    VQQWTNHRVMEWLRSVDL-AEYAPNLRGSGVHGGLMVLePRFNVETM 829  

                   a.klalGitsvghRkkilskiqelkqq<-*
                   a++l ++++++  R+++ ++++ l++    
   mKIAA1230   830 AqLLNIPPNKTLLRRHLATHFNLLIGA    856  

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