hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mph/mph00410/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1142  ( 597 res)   mph00410

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Pkinase     Protein kinase domain                       299.1    5.3e-86   1
Pkinase_Tyr Protein tyrosine kinase                      97.2    3.2e-25   1
PBD         P21-Rho-binding domain                       73.6    4.2e-18   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
PBD           1/1      14    71 ..     1    60 []    73.6  4.2e-18
Pkinase       1/1     327   578 ..     1   287 []   299.1  5.3e-86
Pkinase_Tyr   1/1     327   578 ..     1   272 []    97.2  3.2e-25

Alignments of top-scoring domains:
PBD: domain 1 of 1, from 14 to 71: score 73.6, E = 4.2e-18
                   *->eIStPLtnFkHvvHVGfDgdtGfftGlPpeWekllkssgiskpeqkk
                      eIS+P +nF+H+vH+GfD+ + +ftGlP +W++l   s   +p++  
   mKIAA1142    14    EISAP-SNFEHRVHTGFDQHEQKFTGLPRQWQSLIEES-ARRPKPLI 58   

                   npqavldvlkfys<-*
                   +p++++++++  +   
   mKIAA1142    59 DPACITSIQPGAP    71   

Pkinase: domain 1 of 1, from 327 to 578: score 299.1, E = 5.3e-86
                   *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkrkekskkdktarr
                      +    k+G+Gs G V++a+ +++gk+VAvK++++rk+    ++ +++
   mKIAA1142   327    LDNFIKIGEGSTGIVCIATVRSSGKLVAVKKMDLRKQQR--RELLFN 371  

                   rsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdylse
                     E+ i++  +H+N+v+++ ++  +d+l++V+E++egG     L d+++ 
   mKIAA1142   372 --EVVIMRDYRHENVVEMYNSYLVGDELWVVMEFLEGG----ALTDIVT- 414  

                   trrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldengv
                      ++++   e+++  ++l +l++l+ LH++g+iHRD+K++ ILl ++g 
   mKIAA1142   415 ---HTRM--NEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILLTHDGR 459  

                   vdaflKiaDFGlAkklst.sss.lttfvGTpwYmAPEvllggngygtkvD
                   v    K++DFG+++++  +  ++ +++vGTp++mAPE++  + +yg++vD
   mKIAA1142   460 V----KLSDFGFCAQV-SkEVPrRKSLVGTPYWMAPELIS-RLPYGPEVD 503  

                   vWSlGvilyelltGkpPFsgevqds.ldqlqlirkilgpplefdspewds
                   +WSlGv+++e++ G+pP+ +e   ++l  +++ir +l+p+l+     +  
   mKIAA1142   504 IWSLGVMVIEMVDGEPPYFNE---PpLKAMKMIRDNLPPRLKNLHKAS-- 548  

                   isrsefrrlpnlseeakdLikkcLnkDPskRltaeeilqHPwf<-*
                                +++k +++++L +DP++R ta+e+l+HP++   
   mKIAA1142   549 -------------PSLKGFLDRLLVRDPAQRATAAELLKHPFL    578  

Pkinase_Tyr: domain 1 of 1, from 327 to 578: score 97.2, E = 3.2e-25
                   *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtLkeigasseeie
                      l    k+GeG+ G V+ +t +    + +  VAVK++   +   ++  
   mKIAA1142   327    LDNFIKIGEGSTGIVCIATVR----SSGKLVAVKKM---DLRKQQ-- 364  

                   redFlr.EAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegGd
                   r+++l +E+ iM+ + +H+N+V ++   +  g+     l++V+E+ egG 
   mKIAA1142   365 RRELLFnEVVIMRDY-RHENVVEMYNSYLV-GDE----LWVVMEFLEGGA 408  

                   LldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcLV
                   L d   +     + + ++   ++l + ++++ L++++++HRD+    +L+
   mKIAA1142   409 LTDIVTHT----RMNEEQIAAVCLAVLQALAVLHAQGVIHRDIKSDSILL 454  

                   senlvVKIsDFGLaRdiynddyYvrkkgggk.lPvkWmAPEslkygkFts
                   ++++ VK sDFG + ++ +++   + + ++      WmAPE ++   +  
   mKIAA1142   455 THDGRVKLSDFGFCAQV-SKE---VPRRKSLvGTPYWMAPELISRLPYGP 500  

                   kSDVWSFGVlLWEiftlGeqPFYpgmsneevlellyed..GyRLprPenC
                   + D+WS GV+  E++  Ge+P Y + ++   ++++ +d+   RL+  +++
   mKIAA1142   501 EVDIWSLGVMVIEMVD-GEPP-YFNEPPLKAMKMI-RDnlPPRLKNLHKA 547  

                   PdelYdlMlqCWaedPedRPtFsel..verL<-*
                   ++ l     +   +dP++R t +el ++ +L   
   mKIAA1142   548 SPSLKGFLDRLLVRDPAQRATAAELlkHPFL    578  

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