hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg00857/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA1132 ( 1723 res) mbg00857 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- fn3 Fibronectin type III domain 357.4 1.5e-103 6 ig Immunoglobulin domain 217.7 1.7e-61 7 I-set Immunoglobulin I-set domain 200.7 2.3e-56 7 V-set Immunoglobulin V-set domain 31.7 1.7e-05 4 C2-set_2 CD80-like C2-set immunoglobulin domain 5.4 0.17 1 C1-set Immunoglobulin C1-set domain -10.0 0.32 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- ig 1/7 8 67 .. 1 65 [] 33.0 7e-06 I-set 1/7 1 83 [. 1 97 [] 13.0 0.0011 ig 2/7 101 166 .. 1 65 [] 31.8 1.6e-05 I-set 2/7 87 174 .. 1 97 [] 35.1 1.6e-06 C1-set 1/1 94 177 .. 1 92 [] -10.0 0.32 ig 3/7 189 247 .. 1 65 [] 32.2 1.2e-05 V-set 1/4 175 264 .. 1 130 [] 8.4 0.089 I-set 3/7 175 264 .. 1 97 [] 15.7 0.00066 ig 4/7 280 341 .. 1 65 [] 39.5 7.6e-08 C2-set_2 1/1 267 350 .. 1 101 [] 5.4 0.17 V-set 2/4 268 357 .. 1 130 [] 7.1 0.12 I-set 4/7 266 357 .. 1 97 [] 21.6 0.00022 ig 5/7 374 439 .. 1 65 [] 28.1 0.00021 I-set 5/7 360 456 .. 1 97 [] 49.5 7.7e-11 V-set 3/4 360 456 .. 1 130 [] 9.0 0.077 ig 6/7 473 539 .. 1 65 [] 23.1 0.0066 I-set 6/7 459 555 .. 1 97 [] 21.8 0.00021 fn3 1/6 557 644 .. 1 84 [] 67.6 2.6e-16 fn3 2/6 656 748 .. 1 84 [] 67.8 2.3e-16 fn3 3/6 760 849 .. 1 84 [] 66.9 4.4e-16 fn3 4/6 861 947 .. 1 84 [] 70.6 3.3e-17 ig 7/7 974 1035 .. 1 65 [] 30.0 5.4e-05 I-set 7/7 960 1051 .. 1 97 [] 43.9 3.7e-09 V-set 4/4 959 1062 .. 1 130 [] 7.3 0.11 fn3 5/6 1054 1137 .. 1 84 [] 75.5 1.1e-18 fn3 6/6 1151 1233 .. 1 84 [] 24.5 0.0026 Alignments of top-scoring domains: ig: domain 1 of 7, from 8 to 67: score 33.0, E = 7e-06 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G++v L+C +g+p+ t++W+rn + +g ++ s + ++ t mKIAA1132 8 GSTVILSCAL--TGSPEFTIRWYRNTElVLpG-EAISIRGLSNET-- 49 tsLtitnvtpeDggtYtCvv<-* L i++++++++g Y C + mKIAA1132 50 --LLISSAQKSHSGAYQCFA 67 I-set: domain 1 of 7, from 1 to 83: score 13.0, E = 0.0011 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp k ++ +G+++ ++C tG+Pe t+ W+++ + + + mKIAA1132 1 -------KKLKTGIGSTVILSCALTGSPEFTIRWYRNTELVLP---- 36 sdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtVq ++ ++++ + tL Is +q++ sG Y C At +a +a+ a + mKIAA1132 37 GEAISIRGLS---NETLLISSAQKSHSGAYQCFATRKAQTAQDFAIIVLE 83 <-* mKIAA1132 - - ig: domain 2 of 7, from 101 to 166: score 31.8, E = 1.6e-05 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq Ge ++L C ++ g p++tvtW ++ ++ ++ ++++ ++ + ++ mKIAA1132 101 GEQFSLMCAAK--GAPPPTVTWALDDEpVVrDGSHRTNQYTMSDGTT 145 t.sLtitnvtpeDggtYtCvv<-* +++ ++t + Dgg+Y+C++ mKIAA1132 146 IsHMNVTGPQIRDGGVYRCTA 166 I-set: domain 2 of 7, from 87 to 174: score 35.1, E = 1.6e-06 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P+++ + +V+ Ge ++ C ++G P+PtV+W d++p+ mKIAA1132 87 PRIVSSFSEKVVNPGEQFSLMCAAKGAPPPTVTWALDDEPVVR---- 129 sdrfkvtydg...GsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeL ++ ++ ++G ++ + + q++D G+Y+C+A+Ns+G+ae mKIAA1132 130 DGSHRTNQYTmsdGTTISHMNVTGPQIRDGGVYRCTARNSVGSAE----- 174 tVq<-* mKIAA1132 - --- - C1-set: domain 1 of 1, from 94 to 177: score -10.0, E = 0.32 *->ppgspepelgkpntLvClVtgFyPpdItVtW.lkNGqevtegveste ++ + + g++ +L+C ++g Pp tVtW l + +v +g++ t mKIAA1132 94 SE-KVV-NPGEQFSLMCAAKGAPPP--TVTWaLDDEPVVRDGSHRTN 136 plpkngDgtYqlsSyLtftasepesgdsYtCrVeHesLkvenePlt<-* ++ +Dgt + S+ ++t + ++g +Y C+ + ++ eP mKIAA1132 137 QYT-MSDGT--TISHMNVTGPQIRDGGVYRCTARNSVGSA--EPPS 177 ig: domain 3 of 7, from 189 to 247: score 32.2, E = 1.2e-05 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G + ++C+v g p +++ W+++ l++ +++ ++en++ mKIAA1132 189 GRDTLINCRV--IGYPYYSIKWYKDALlLPdNHRQVVFENGT----- 228 tsLtitnvtpe.DggtYtCvv<-* L +t+v+++ D+g+Y C v mKIAA1132 229 --LKLTDVQKGmDEGEYLCSV 247 V-set: domain 1 of 4, from 175 to 264: score 8.4, E = 0.089 *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss + ++ + r +t++ G + +++C + ++ mKIAA1132 175 PPSIRA--MR----------NITAVAGRDTLINCRVI----GY---- 201 gtgsvyWyrq.qppGekpeliiisyytyysysegngtvserfkgrvrfsg +s+ Wy++ + +++++ f + + mKIAA1132 202 PYYSIKWYKDaLLLPDNHRQVV-------------------FENGT---- 228 npskgdfsLtIsnlqls.DsGtYyCa.........gggtrLtVl<-* L+++++q D+G Y C + + +++++ V+ mKIAA1132 229 --------LKLTDVQKGmDEGEYLCSvliqpqlsiSQSVHVAVK 264 I-set: domain 3 of 7, from 175 to 264: score 15.7, E = 0.00066 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp P ++ +++++ G + C+V+G+P ++ W+Kd l+ mKIAA1132 175 PPSIRAMRNITAVAGRDTLINCRVIGYPYYSIKWYKDALLLPD---- 217 sdrfkvtydgGsgtytLtIsnvqpd.DsGkYtCvAtNs.aGeaeasaeLt +r v ++g tL+ +vq++ D+G+Y C + + + + s+++ mKIAA1132 218 NHRQVVFENG-----TLKLTDVQKGmDEGEYLCSVLIQpQLSISQSVHVA 262 Vq<-* V+ mKIAA1132 263 VK 264 ig: domain 4 of 7, from 280 to 341: score 39.5, E = 7.6e-08 *->GesvtLtCsvsgfgppdvtvtWlrngklt.gvlvtssenngdstyqt G+ + ++C vs +g+ ++++tW+++g+++ + ++ + e++ ++ mKIAA1132 280 GQLLYIPCVVS-SGDMPIRITWRKDGQVIiSGSGVTIESKEFMSS-- 323 sLtitnvtpeDggtYtCvv<-* L+i++v+ ++g+YtC + mKIAA1132 324 -LQISSVSLKHNGNYTCIA 341 C2-set_2: domain 1 of 1, from 267 to 350: score 5.4, E = 0.17 *->peIeppasllegeksenlevvatCvlpysagGkPapritWyldgkel p I+p + ++ +l ++ Cv +++G + ritW++dg+ mKIAA1132 267 PLIQPF-EFPPAS-IGQLLYI-PCV---VSSGDMPIRITWRKDGQVI 307 vpeekteaittsseqdpesglytvtStLklvpsredhgqsltCqvsygal i+ s + ++ ++ ++ + ++ ++ h+ + tC++s+ a mKIAA1132 308 --------ISGSGVTIESKEFMSSLQISSVSLK---HNGNYTCIASNAAA 346 rgsk<-* +s+ mKIAA1132 347 TVSR 350 V-set: domain 2 of 4, from 268 to 357: score 7.1, E = 0.12 *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss ++ + p+ ++ G+ + +pC +s ++ mKIAA1132 268 LIQPFE-FPP-------------ASIGQLLYIPCVVS---SGD---- 293 gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn ++ +++W + +ii +g+ ++ mKIAA1132 294 MPIRITWRK-DGQ-----VII--------------------SGSG-VTIE 316 pskgdfsLtIsnlqlsDsGtYyCa........gggtrLtVl<-* + sL+Is+++l ++G Y+C ++ + + +L+V+ mKIAA1132 317 SKEFMSSLQISSVSLKHNGNYTCIasnaaatvSRERQLIVR 357 I-set: domain 4 of 7, from 266 to 357: score 21.6, E = 0.00022 *->PkFtqkpkdveVqeGesarfeCkV.tGtPePtVsWfKdGqplssvll P +q+ + +++G+ + C V++G+ + ++W KdGq + s mKIAA1132 266 PPLIQPFEFPPASIGQLLYIPCVVsSGDMPIRITWRKDGQVIIS--- 309 psdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLtV ++ + + ++ ++L Is v G YtC+A+N a +++ + +L+V mKIAA1132 310 -GSGVTIESKE--FMSSLQISSVSLKHNGNYTCIASNAAATVSRERQLIV 356 q<-* + mKIAA1132 357 R 357 ig: domain 5 of 7, from 374 to 439: score 28.1, E = 0.00021 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvtssenngdstyq G+ L+Csv g p+++v W++++++ + +++ ++ ++++++ mKIAA1132 374 GKAGVLNCSV--DGYPPPKVMWKHAKGsGNpQQYH--PVPLTGRIQI 416 t...sLtitnvtpeDggtYtCvv<-* +++sL i+ v +eD g+Y C++ mKIAA1132 417 LpnsSLLIRHVLEEDIGYYLCQA 439 I-set: domain 5 of 7, from 360 to 456: score 49.5, E = 7.7e-11 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKd.Gq....... P+F+ +p ++ G++ ++ C V+G+P+P+V W++ +G++++++ + mKIAA1132 360 PRFVVQPNNQDGIYGKAGVLNCSVDGYPPPKVMWKHAkGSgnpqqyh 406 plssvllpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeae p++ ++r+++ + +L I+ v +D G Y C+A+N +G++ mKIAA1132 407 PVPL----TGRIQILPNS-----SLLIRHVLEEDIGYYLCQASNGVGTDI 447 asa.eLtVq<-* ++a +LtV+ mKIAA1132 448 SKAmFLTVK 456 V-set: domain 3 of 4, from 360 to 456: score 9.0, E = 0.077 *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss + v q p + G+ L+C++ ++ mKIAA1132 360 PRFVVQ--PN----------NQDGIYGKAGVLNCSVD----GY---- 386 gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn + v W + + p++ + + ++ gr+++ +n mKIAA1132 387 PPPKVMWKH-AKGSGNPQQYH----------------PVPLTGRIQILPN 419 pskgdfsLtIsnlqlsDsGtYyCa.........gggtrLtVl<-* s L I+++ +D G Y C+ +++ +++ + + LtV+ mKIAA1132 420 SS-----LLIRHVLEEDIGYYLCQasngvgtdiSKAMFLTVK 456 ig: domain 6 of 7, from 473 to 539: score 23.1, E = 0.0066 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvt.ssenngdsty G++ L+C++ g ++ ++W ++++ + ++ + + ++++++ mKIAA1132 473 GHPKELNCTA--RGERPIIIRWEKGDTvIDpDRVMRyAIATKDNGDE 517 qt.sLtitnvtpeDggtYtCvv<-* ++L +++++++D+ +++C++ mKIAA1132 518 VVsTLKLKPADRGDSVFFSCHA 539 I-set: domain 6 of 7, from 459 to 555: score 21.8, E = 0.00021 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKdGqplssvllp +t +p + G + ++ C+++G+ + + W K++ + + mKIAA1132 459 AMITSHPNTTIAIKGHPKELNCTARGERPIIIRWEKGDTVIDP---- 501 sd..rfkvtydg..GsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasae ++ r+ + ++++ +tL+ + ++++Ds +C A Ns+Ge+ ++ mKIAA1132 502 DRvmRYAIATKDngDEVVSTLKLKPADRGDSVFFSCHAINSYGEDRGLIQ 551 LtVq<-* LtVq mKIAA1132 552 LTVQ 555 fn3: domain 1 of 6, from 557 to 644: score 67.6, E = 2.6e-16 *->PsaPtnltvtdvtstsltlsWsppt.gngpitgYevtyRqpkngge. P+ P l +++v + s+ l+W+ ++gn+ itg+ ++y ++k++ ++ mKIAA1132 557 PPDPPELEIREVKARSMNLRWTQRFdGNSIITGFDIEY-KNKSDSWd 602 ..wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* + ++++++t +++++ +L P + Y++r ++ n +G++++S mKIAA1132 603 fkQSTRNISPTINQANIVDLHPASVYSIRMYSFNKIGrSEPS 644 fn3: domain 2 of 6, from 656 to 748: score 67.8, E = 2.3e-16 *->P.saPtnltvtdvtstsltlsWsppt...gngpitgYevtyR..qpk P+++P ++t +vts s++++W++p+++ ng+i gY++ yR+++p mKIAA1132 656 PdGPPMDVTLQPVTSQSIQVTWKAPKkelQNGVIRGYQIGYRenSPG 702 ngge..wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* ++g+ + +e +g++ ytl +Lk +Y v VqA n++G+Gp S mKIAA1132 703 SNGQysIVEMKATGDSEVYTLDNLKKFAQYGVVVQAFNRAGtGPSS 748 fn3: domain 3 of 6, from 760 to 849: score 66.9, E = 4.4e-16 *->PsaP.tnltvtdvtstsltlsWsppt...gngpitgYevtyRqpkng Ps+P++n+++ ++ts+ +++sWs p++++ ng++ gY+v ++ mKIAA1132 760 PSQPpENVRALSITSDVAVISWSEPPrttLNGVLKGYRVIF-WSLYV 805 ge....wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* ++ ++ +++t ++ ++l+g + t+Y+v+V A++++G+G +S mKIAA1132 806 DGewgeMQNVTTTRER--VELRGMEKFTNYSVQVLAYTQAGdGVRS 849 fn3: domain 4 of 6, from 861 to 947: score 70.6, E = 3.3e-17 *->PsaPtnltvtdvtstsltlsWsppt.gngpitgYevtyRqpkngge. P++P ++++ + +++s+++sW ppt++ng+i +Y++ + ++ ++g++ mKIAA1132 861 PGPPAGIKAVPSSASSVVVSWLPPTkPNGVIRKYTIFC-SSPGSGQp 906 .wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* + e+ ++ + y + L+ g +Y ++V+Av+ +G+G S mKIAA1132 907 aPSEYETSPEQLFYRIAHLNRGQQYLLWVAAVTSAGrGNSS 947 ig: domain 7 of 7, from 974 to 1035: score 30.0, E = 5.4e-05 *->GesvtLtCsvsgfgppdvtvtWlrngk.lt.gvlvt.ssenngdsty ++v+L+C + g+p + v W++++ + +v+ ++ ++++t mKIAA1132 974 MKDVRLPCNS--VGDPAPAVKWTKDSEdSAiPVSLDgHRLIHTNGT- 1017 qtsLtitnvtpeDggtYtCvv<-* L +++v+ eD+g+YtC++ mKIAA1132 1018 ---LLLRAVKAEDSGYYTCTA 1035 I-set: domain 7 of 7, from 960 to 1051: score 43.9, E = 3.7e-09 *->PkFtqkpkdveVqeGesarfeCkVtGtPePtVsWfKd..Gqplssvl k++ v+ +++r+ C+ G+P P V W+Kd++++ +++ + mKIAA1132 960 AKIISFGGTVTTPWMKDVRLPCNSVGDPAPAVKWTKDseDSAIPV-S 1005 lpsdrfkvtydgGsgtytLtIsnvqpdDsGkYtCvAtNsaGeaeasaeLt l+ ++ +++ tL + v+ +DsG YtC+AtN +G ++ ++L mKIAA1132 1006 LD--GHRLIHTN----GTLLLRAVKAEDSGYYTCTATNTGGFDTIIVNLL 1049 Vq<-* Vq mKIAA1132 1050 VQ 1051 V-set: domain 4 of 4, from 959 to 1062: score 7.3, E = 0.11 *->qstvtqepprLLLASLfWptsvtvaeGgsvtLpCtysGtfddsssss + + + vt + ++v+LpC +d+ mKIAA1132 959 PAKIIS-FGG----------TVTTPWMKDVRLPCNSV---GDP---- 987 gtgsvyWyrqqppGekpeliiisyytyysysegngtvserfkgrvrfsgn ++ v W + + +s + +++g + + +n mKIAA1132 988 AP-AVKWTK-DSE--------------DSAI------PVSLDGHRLIHTN 1015 pskgdfsLtIsnlqlsDsGtYyCa...................gggtrLt ++ L ++ ++++DsG Y+C +++++ ++ + + rLt mKIAA1132 1016 GT-----LLLRAVKAEDSGYYTCTatntggfdtiivnllvqvpPDQPRLT 1060 Vl<-* V+ mKIAA1132 1061 VS 1062 fn3: domain 5 of 6, from 1054 to 1137: score 75.5, E = 1.1e-18 *->PsaPtnltvtdvtstsltlsWsppt.gngpitgYevtyRqpknggew P++P+ ltv+ ++++s+tl+W p ++g++ i g+ ++y + +n++ew mKIAA1132 1054 PDQPR-LTVSKTSASSITLTWIPGDnGGSSIRGFVLQY-SVDNSEEW 1098 neltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* + + ++++++s+ l Lk gt Y+v+++A n +G+G+ S mKIAA1132 1099 KDVFISSSERSFKLDSLKCGTWYKVKLAAKNSVGsGRIS 1137 fn3: domain 6 of 6, from 1151 to 1233: score 24.5, E = 0.0026 *->PsaPtnltvtdvtstsltlsWsppt.gngpitgYevtyRqpkngge. s+ + l +t ++st ++l+ + +g+ pit ++yR pk g + mKIAA1132 1151 FSKDQHL-FTHINSTHARLNLQGWNnGGCPITAIVLEYR-PK-GTWa 1194 wneltvpgtttsytltgLkPgteYevrVqAvnggG.GpeS<-* w+ ++ ++t ++ lt L++ t Ye+r +A n +G G e+ mKIAA1132 1195 WQGVRANSST-EVFLTELREATWYELRMRACNSAGcGNET 1233 //