hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mth/mth00654/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1131  ( 1571 res)   mth00654

Scores for sequence family classification (score includes all domains):
Model        Description                                Score    E-value  N 
--------     -----------                                -----    ------- ---
HECT         HECT-domain (ubiquitin-transferase)        462.6   3.4e-135   1
Sad1_UNC     Sad1 / UNC-like C-terminal                 134.0    2.7e-36   1
MIB_HERC2    Mib_herc2                                  130.6    2.8e-35   1
F5_F8_type_C F5/8 type C domain                          -0.2       0.86   1

Parsed for domains:
Model        Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------     ------- ----- -----    ----- -----      -----  -------
F5_F8_type_C   1/1      60   195 ..     1   163 []    -0.2     0.86
Sad1_UNC       1/1      68   201 ..     1   147 []   134.0  2.7e-36
MIB_HERC2      1/1     238   299 ..     1    69 []   130.6  2.8e-35
HECT           1/1    1140  1571 .]     1   366 []   462.6 3.4e-135

Alignments of top-scoring domains:
F5_F8_type_C: domain 1 of 1, from 60 to 195: score -0.2, E = 0.86
                   *->qitaSseesgsggagrarLwspaaaalDGngntyghsvspstaWsse
                       + +Sse ++ + +        ++ +  +n ++      ++   +s 
   mKIAA1131    60    VVVTSSEGRNLPYGRL------EDILSRDN-SA------LNC--HS- 90   

                   kwsggaknndapqwlqvDLgkpkkitgvvtqgrqdggngyvksYkiqySd
                   +       +d+++w+ +DLg  +  ++ ++ ++++ g    + +++q+S 
   mKIAA1131    91 N-------DDKNAWFAIDLGVWVIPSAYTLRHARGYGRSALRNWVFQVSK 133  

                   DGseevnWttvkdgedilsdsggpkiFgn.dndpvknlfdppikA.....
                   DG +  nWt++++                +d++    l +p  +A+ + +
   mKIAA1131   134 DG-Q--NWTSLYT--------------HVdDCS----LNEPGSTAtwpld 162  

                   .........RYvRivpts..wnggggiasraEl<-*
                   + ++++++ R+vR++   ++ +g  ++ s++ +   
   mKIAA1131   163 pakdekqgwRHVRLKQMGknASGQTHYLSLSGF    195  

Sad1_UNC: domain 1 of 1, from 68 to 201: score 134.0, E = 2.7e-36
                   *->lnyeaksprvilqedkDkympgpCwsfkgsrGfvvieLsepIiveav
                      +n+++ + + il++d   ++  +C+s+++++++++i+L  ++i++a+
   mKIAA1131    68    RNLPYGRLEDILSRD---NSALNCHSNDDKNAWFAIDLGVWVIPSAY 111  

                   tLeHveksvspdGnf.sSAPKdFeVsgserypdeesTeewvlLGeFtYdl
                   tL+H +        +++SA++++++++s++++  ++T+++++++++++++
   mKIAA1131   112 TLRHARG-------YgRSALRNWVFQVSKDGQ--NWTSLYTHVDDCSLNE 152  

                   dgknlQtFqlqnpCpyiekqswvkyVklrilSNy....GnehYTClYrfR
                   +g+++ t++l++  + +ekq  +++V  r+++++++ +G++hY  l++f+
   mKIAA1131   153 PGSTA-TWPLDPA-K-DEKQ-GWRHV--RLKQMGknasGQTHYLSLSGFE 196  

                   VhGts<-*
                   ++Gt+   
   mKIAA1131   197 LYGTV    201  

MIB_HERC2: domain 1 of 1, from 238 to 299: score 130.6, E = 2.8e-35
                   *->GaRVVRGvDWkWedQDGGeGgvGtVteigrwgStesedgwvdVtWDn
                      GaRV+RG DWkW+dQDG + g+GtVt+       e ++gw+dVtWD+
   mKIAA1131   238    GARVIRGLDWKWRDQDGSPQGEGTVTG-------ELHNGWIDVTWDA 277  

                   GsrNsYRmGaeGkyDLklvdsa<-*
                   G +NsYRmGaeGk+DLkl++ +   
   mKIAA1131   278 GGSNSYRMGAEGKFDLKLAPGY    299  

HECT: domain 1 of 1, from 1140 to 1571: score 462.6, E = 3.4e-135
                   *->tLlsrelfnPdygLFeysd.n.seak.see.d.d.sysg.yvedsyt
                       L++ e++++d+g ++++d++++++++  +  ++ +++g yv+ s++
   mKIAA1131  1140    ALVAAEFQRTDLGTWLCDDnFpDDESrHVDlGgGlKPPGyYVQRSCG 1186 

                   lfpnPlsgesnpehervlkyFkflGrilGlAlydgrllDlpFsraFyKkl
                   lf +P++ +s++++ r+ k+F+flG++l+++++d+rl+Dlp s++F+K++
   mKIAA1131  1187 LFTAPFPQDSDELE-RITKLFHFLGIFLAKCIQDNRLVDLPISKPFFKLM 1235 

                   Lm.a.gkp..........................................
                   +m++ +   ++   +++++++ + ++++++ ++++++++ + ++ +++++
   mKIAA1131  1236 CMgDiKSNmskliyesrgdrdlhctesqseasteeghdslsvgsfeedsk 1285 

                   ..............s.igivtleDlesvDPelynSLkwllendgdKk.Ie
                   ++   ++++++++ +  gi+t+eD+e v+P+ +++Lk+++++ + +++I+
   mKIAA1131  1286 sefildppkpkppaWfNGILTWEDFELVNPHRARFLKEIKDLAIKRRqIL 1335 

                   .d.s............L.L.g...s.ledveedLeLtFsveeessvgfea
                   +++s ++++++++ ++L L+++++s+++ ++edL+L+F+ +++s +    
   mKIAA1131  1336 gNkSlsedekntklqeLvLrNpsgSgPPLSIEDLGLNFQFCPSSRI---- 1381 

                   darffGgtktveELkPnGrnipVTneNkeeYvelyvdyrLnkgiekQfeA
                         g++ v+ LkP G++ + T +N eeYv+l+ d+ + +gi+kQ+eA
   mKIAA1131  1382 -----YGFTAVD-LKPSGEDEMITMDNAEEYVDLMFDFCMHTGIQKQMEA 1425 

                   FrkGFsevipsrlLslFdpeELelLicGsp.eeiDvddLkenTeYdggYt
                   Fr+GF++v+p++ Ls F+ eE+++++cG++++ +  +d++++Te++ gYt
   mKIAA1131  1426 FRDGFNKVFPMEKLSSFSHEEVQMILCGNQsPSWAAEDIINYTEPKLGYT 1475 

                   edsplktiqwFWevleeftneeraklLqFvTGssRlPvgGFkaLqgGsnG
                   +dsp   + +F +vl +++++er+++LqF+TG+s lP+gG+++L+     
   mKIAA1131  1476 RDSP--GFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLH----- 1518 

                   pPkFtIvrkegggdddrLPtAhTCFNrLkLPpYsSkeiLrekLllAInEg
                    P++t+vrk ++ +d ++P+++TC+++LkLP+YsS ei+re+Ll A +E 
   mKIAA1131  1519 -PRLTVVRK-VDATDASYPSVNTCVHYLKLPEYSSEEIMRERLLAATME- 1565 

                   seGFgle<-*
                    +GF+l+   
   mKIAA1131  1566 -KGFHLN    1571 

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