hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg04765/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1123  ( 1389 res)   mbg04765

Scores for sequence family classification (score includes all domains):
Model       Description                                 Score    E-value  N 
--------    -----------                                 -----    ------- ---
Ion_trans   Ion transport protein                       441.6   6.7e-129   2
PKD_channel Polycystin cation channel                  -156.9       0.16   1

Parsed for domains:
Model       Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------    ------- ----- -----    ----- -----      -----  -------
Ion_trans     1/2     411   638 ..     1   228 []   238.9  7.4e-68
Ion_trans     2/2     744   952 ..     1   228 []   211.0  1.8e-59
PKD_channel   1/1     602   959 ..     1   458 []  -156.9     0.16

Alignments of top-scoring domains:
Ion_trans: domain 1 of 2, from 411 to 638: score 238.9, E = 7.4e-68
                   *->ileildyvftviFtlEmllkiialgfklhsriafkYlrspwNilDfl
                      +l+  +y+ft++F++Em +k++alg++++    ++Ylrs wN+lD l
   mKIAA1123   411    FLTLSNYIFTAVFLAEMTVKVVALGWCFG---EQAYLRSSWNVLDGL 454  

                   vvlpslislilsllgggsegdlyvreskfsttpe.gsygllsvlrllRll
                    vl+s+i++++s++ +                 +++   +l++lr+lRll
   mKIAA1123   455 LVLISVIDILVSMVSD-----------------SgT--KILGMLRVLRLL 485  

                   RvLRllrlirrapglfRWelrtlGWelnslgrslksllnvllllllllfi
                   R+LR+lr+i+ra+g     l+ +   + +l+ slk+++n++++++ +++i
   mKIAA1123   486 RTLRPLRVISRAQG-----LKLV---VETLMSSLKPIGNIVVICCAFFII 527  

                   faiigvqlFggelnkcc..................npingntnFdsfgna
                   f+i+gvqlF+g+++ c ++++ + ++++++ + + +++  + nFd+ g+a
   mKIAA1123   528 FGILGVQLFKGKFFVCQgedtrnitnksdcaeasyRWVRHKYNFDNLGQA 577  

                   llwlFqtmTteGwgdvmpdtl...........agtvlgkiyfvsfiilgg
                   l++lF++++ +Gw+d+m+d+l+  + ++++  ++++++ +yf+sf ++++
   mKIAA1123   578 LMSLFVLASKDGWVDIMYDGLdavgvdqqpimNHNPWMLLYFISFLLIVA 627  

                   flllNLfiavi<-*
                   f++lN+f++v+   
   mKIAA1123   628 FFVLNMFVGVV    638  

Ion_trans: domain 2 of 2, from 744 to 952: score 211.0, E = 1.8e-59
                   *->ileildyvftviFtlEmllkiialgfklhsriafkYlrspwNilDfl
                      +l+i++y+ftviF+lE ++k++a+gf       +++++++wN lD++
   mKIAA1123   744    ALKICNYIFTVIFVLESVFKLVAFGF-------RRFFQDRWNQLDLA 783  

                   vvlpslislilsllgggsegdlyvreskfsttpe.gsygllsvlrllRll
                   +vl+s+++++l++ +++              ++ ++++++++++r+lR+ 
   mKIAA1123   784 IVLLSIMGITLEEIEVN--------------ASLpINPTIIRIMRVLRIA 819  

                   RvLRllrlirrapglfRWelrtlGWelnslgrslksllnvllllllllfi
                   R   +l+l+++a g     +r l   l +++++l++ +n++ll++ll+fi
   mKIAA1123   820 R---VLKLLKMAVG-----MRAL---LDTVMQALPQVGNLGLLFMLLFFI 858  

                   faiigvqlFggelnkcc...npingntnFdsfgnallwlFqtmTteGwgd
                   fa +gv lFg+ + ++ +++++ +++  F++fg+a+l+lF+++T+++w++
   mKIAA1123   859 FAALGVELFGDLECDEThpcEGLGRHATFRNFGMAFLTLFRVSTGDNWNG 908  

                   vmpdtl.........agtvlgkiyfvsfiilggflllNLfiavi<-*
                   +m dtl++ +++++  +tv++ iyfvsf++   f+l+N++iav+   
   mKIAA1123   909 IMKDTLrdcdqestcYNTVISPIYFVSFVLTAQFVLVNVVIAVL    952  

PKD_channel: domain 1 of 1, from 602 to 959: score -156.9, E = 0.16
                   *->spglltvtdlddiwdwls...svLLpglywtktsnNqstsgnegfih
                       ++ + ++   +  +w+    +++L+ +                 ++
   mKIAA1123   602    GVDQQPIM---NHNPWMLlyfISFLLIVA----------------FF 629  

                   yessllLGvpRLRQvRvrnssctvppdfrdeinevaEIHChavyspgseD
                      +   Gv+      v+n            +       C+   ++++  
   mKIAA1123   630 VL-NMFVGVV------VEN------------FHK-----CRQHQEEEEAR 655  

                   tkdYspsWslPykrmgyndkdwriYspwvPseyspeFLneLLlgawhwGv
                   ++          kr+   +k+ r+              +++  +++++ +
   mKIAA1123   656 RREE--------KRLKRLEKKRRNLML-----------DDV-IASGSSAS 685  

                   lasYpsvgGYvvlLplsreeslkalaeLqdnnWLDrrTRAvFveFtlYNa
                   +as    + Y+++  +sr++ l     L  ++ LD     +F+       
   mKIAA1123   686 AASEAQCKPYYSD--YSRFRLLV--HHLCTSHYLD-----LFI------- 719  

                   ntNLFcvvtLlvEfPpsGgvlpsvsvqsvkLlryvtglslflllceiifl
                                   +G++   + v + ++  y+    l + l  i+ +
   mKIAA1123   720 ----------------TGVI--GLNVVTMAMEHYQQPQILDEAL-KICNY 750  

                   vfvlyFvveeitkirregIlsylrsvWnlLdlaivalsvvvivLhiyRdf
                   +f + Fv e ++k+   g ++ + + Wn+Ldlaiv+ls+           
   mKIAA1123   751 IFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIVLLSI----------- 789  

                   latqlwkqvlkaspvdFidFdrvarldqlyriilAfllFLtwlKlfkvLr
                        + + l ++ + ++++    +   ++r+       L + +++k+L 
   mKIAA1123   790 -----MGITL-EEIEVNASLPINPTIIRIMRV-------LRIARVLKLLK 826  

                   FnrtmslftkTLsralkellgfavmfvIlflAYaqlgyLlfGs.......
                    +  m+ +  T   al+ +  ++++f +lf+ +a+lg+ lfG  + ++++
   mKIAA1123   827 MAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGDlecdeth 876  

                   ......qvdnfsnfvksiltlVGtcyfrgilgdfqp.......teiesg.
                   + ++ + +++f+nf  ++ltl     fr  +gd  ++  +++  ++++++
   mKIAA1123   877 pceglgRHATFRNFGMAFLTL-----FRVSTGDNWNgimkdtlRDCDQEs 921  

                   ...nrvLGpLlfltfvflvifiLLNlflaiIndsYnev<-*
                   +  n+v +p++f++fv+   f+L N+ +a+++   +e    
   mKIAA1123   922 tcyNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEES    959  

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