hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj15083/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1099  ( 981 res)   mfj15083

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
ArfGap   Putative GTP-ase activating proteins for the   184.3    1.1e-50   1
PH       Pleckstrin homology domain.                     67.4    1.8e-15   1
ANK      ankyrin repeats                                 36.5    3.7e-06   2
RAS      Ras subfamily of RAS small GTPases               7.9    1.6e-08   1
RAB      Rab subfamily of small GTPases                 -33.7    4.3e-06   1

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RAB        1/1     196   356 ..     1   172 []   -33.7  4.3e-06
RAS        1/1     193   356 ..     1   167 []     7.9  1.6e-08
PH         1/1     471   714 ..     1    82 []    67.4  1.8e-15
ArfGap     1/1     733   853 ..     1   139 []   184.3  1.1e-50
ANK        1/2     892   921 ..     1    30 []    26.7   0.0032
ANK        2/2     925   956 ..     1    30 []     9.7  2.3e+02

Alignments of top-scoring domains:
RAB: domain 1 of 1, from 196 to 356: score -33.7, E = 4.3e-06
                   *->FKiilIGDSGVGKSsLLsRFtddkFsedsksTIGVDFktktievdGk
                      +K+ ++G+ + GKS L++R+ ++++ ++ ++  G  Fk k i vdG+
   mKIAA1099   196    LKVGIVGNLASGKSALVHRYLTGTYVQEESPEGG-RFK-KEIVVDGQ 240  

                   rvKLQIWDTAGQERFRSiTssYYRG............AvGalLVYDiTnr
                      L I                 R+++++++ +     +++++V+ + ++
   mKIAA1099   241 SYLLLI-----------------RDeggppeaqfamwVDAVIFVFSLEDE 273  

                   eSFenlknWlkelreyadpppenvvimLVGNKsDLee..qRqVstEeaek
                    SF+ + +  ++   y +   + ++ +LVG     ++++ R+++  +a+k
   mKIAA1099   274 ISFQTVYHYYSRMANYRNT--SEIPLVLVGTQDAISStnPRVIDDVRARK 321  

                   ficDcAeehgllFifETSAKtntNVeeAFeelakkIlkr<-*
                   +     +   + ++ ET A  ++NVe +F+ +a+kI+++   
   mKIAA1099   322 L---SNDLKRCTYY-ETCATYGLNVERVFQDVAQKIVAT    356  

RAS: domain 1 of 1, from 193 to 356: score 7.9, E = 1.6e-08
                   *->mreYKlVVlGgGGVGKSALTiQFiqghFvdeYDPTIEDS.....YRK
                      ++e K+ ++G    GKSAL+ +  +g++v+      E S+++++++K
   mKIAA1099   193    VPELKVGIVGNLASGKSALVHRYLTGTYVQ------EESpeggrFKK 233  

                   qieiDgevalLDILDTAGQeEFsAMRdqYmRtGeGFlLVYSitsrqSFee
                   +i++Dg+ +lL I D  G  E      q+    +  + V+S+ +  SF+ 
   mKIAA1099   234 EIVVDGQSYLLLIRDEGGPPE-----AQFAMWVDAVIFVFSLEDEISFQT 278  

                   ikkfreqIlRVKdrddvPivLVGNKcDLene...RqVsteEGkeLAkqln
                   +  ++  +   + + ++P+vLVG   D  + +++R++    +++L+++l+
   mKIAA1099   279 VYHYYSRMANYRNTSEIPLVLVGT-QDAISStnpRVIDDVRARKLSNDLK 327  

                   .cpFlEtSAKerinVdeaFydLVReirks<-*
                   +c ++Et A +  nV+ +F+d+   i +    
   mKIAA1099   328 rCTYYETCATYGLNVERVFQDVAQKIVAT    356  

PH: domain 1 of 1, from 471 to 714: score 67.4, E = 1.8e-15
                   *->vikeGwLlkks....k.swkkryfvLfngvLlyyksk.......kpk
                      +ik+G Llk+s+++ ++ wkk+y++L+++ +l y+++ ++  ++ + 
   mKIAA1099   471    PIKQGMLLKRSgkslNkEWKKKYVTLCDNGVLTYHPSlhdymqnVHG 517  

                   gsipLsgcsvre.p....................................
                   ++i+L   +v+++ +++++  +   + ++++ ++  ++ ++ + ++++++
   mKIAA1099   518 KEIDLLRTTVKVpGkrppratsacapissprtnglakdmsslhispnsgn 567  

                   ..................................................
                     + +++   ++ +  + ++++++ + ++ + ++ +  ++     ++  +
   mKIAA1099   568 vtsasgsqmasgislvsfnsrpdgmhqrsysvssadqwsdatviansais 617  

                   ..................................................
                   ++ + +++  ++++ +++ +++ +++++++ ++++++++++ ++ + ++ 
   mKIAA1099   618 sdtglgdsvcsspsissstspkldpppsphanrkkhrrkkstsnfkadgl 667  

                   ...........cFeivt.dr.tlllqAeseeereeWvealqsaiaka<-*
                   ++  ++ +++  F iv+ +++t+++ A + eer+ Wv+a++s i  +   
   mKIAA1099   668 sgtaeeqeenlEFIIVSlTGqTWHFEATTYEERDAWVQAIESQILAS    714  

ArfGap: domain 1 of 1, from 733 to 853: score 184.3, E = 1.1e-50
                   *->eealqlLRsikpgNkkCfDCGavpnPtWaSvnlGvflCieCSGiHRs
                      + alq++R+++ gN++C+DC+   nP WaS+nlG++ CieCSGiHR+
   mKIAA1099   733    AMALQSIRNMR-GNSHCVDCDT-QNPNWASLNLGALMCIECSGIHRN 777  

                   LfGvHiSkVnvRSltLDtWteeeLrllesckgGNenansfwesnlddfsl
                   L G+H+S+V  RSl+LD+W+ e ++++    +GNe ans+we     + +
   mKIAA1099   778 L-GTHLSRV--RSLDLDDWPMELIKVMS--SIGNELANSVWEEGSQGRTK 822  

                   kpkdsdaaasvKCeddrqkyesfiaaKYeeklfrvdkesaee<-*
                   ++ ds           r+++e +i+aKYe+klf + ++++ e   
   mKIAA1099   823 PSLDS----------TREEKERWIRAKYEQKLF-LAPLPCTE    853  

ANK: domain 1 of 2, from 892 to 921: score 26.7, E = 0.0032
                   *->dGrTpLHlAaengnlevvklLldkgadina<-*
                      dGrT+LHlA+++gn+ +++lL+ +g+d+ a   
   mKIAA1099   892    DGRTALHLACRKGNVVLAQLLIWYGVDVMA    921  

ANK: domain 2 of 2, from 925 to 956: score 9.7, E = 2.3e+02
                   *->dGrTpLHlAaengnlevvklLldkga..dina<-*
                      +G+T+L +A +  + e++  Ll++g +++  +   
   mKIAA1099   925    HGNTALAYARQASSQECIDVLLQYGCpdERFV    956  

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