hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbg/mbg05205/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1070  ( 846 res)   mbg05205

Scores for sequence family classification (score includes all domains):
Model         Description                               Score    E-value  N 
--------      -----------                               -----    ------- ---
COesterase    Carboxylesterase                          712.0   2.8e-210   1
Abhydrolase_3 alpha/beta hydrolase fold                 -76.0       0.06   1

Parsed for domains:
Model         Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------      ------- ----- -----    ----- -----      -----  -------
Abhydrolase_3   1/1     199   380 ..     1   247 []   -76.0     0.06
COesterase      1/1      32   629 ..     1   591 []   712.0 2.8e-210

Alignments of top-scoring domains:
Abhydrolase_3: domain 1 of 1, from 199 to 380: score -76.0, E = 0.06
                   *->lvYfHGGGFvlGsldthYdalcrrLAaragavVvSVDYR......LA
                      +vY+HGG ++ G+ + + d  +   A++ +++V+ V+YR +  + L+
   mKIAA1070   199    MVYIHGGSYMEGTGNLY-DGSVL--ASYGNVIVITVNYRlgvlgfLS 242  

                   PEhpfPA...AvdDayaAlrWlaehavgsggeddpwlelgaDpsriavaG
                          ++  + D   AlrW  e+             +g+Dp ri+v+G
   mKIAA1070   243 TGDQAAKgnyGLLDLIQALRWTSENI---------G-FFGGDPLRITVFG 282  

                   DSAGGNLAaavAqlrardrGgplaeldpdlspvrpagqvLiyPfFggtDl
                     AGG      +                      +  + L +     +  
   mKIAA1070   283 SGAGGS-----C----------------------VNLLTLSHY---SE-- 300  

                   rertesesyrlsreyadgplLtrdamdwfwrlYLpgadrddPaslasPlf
                           +   + ++   l+ r+  + +  l+        +   +s   
   mKIAA1070   301 ------GNR---WSNSTKGLFQRAIAQSGTALSS-------W--AVS-F- 330  

                   apaspdlegLsGLPPalvvvAefDpLrDegeaYAerLra.WaGVpVelve
                             ++ ++ l    ++     + +++ e L+++     V+  +
   mKIAA1070   331 -----Q---PAKYARILATKVGC--NVSDTVELVECLQKkPYKELVDQDV 370  

                   ypGmiHgFll<-*
                    p   H  +    
   mKIAA1070   371 QPARYHIAFG    380  

COesterase: domain 1 of 1, from 32 to 629: score 712.0, E = 2.8e-210
                   *->mllllllllllllflavvataptspedpvVeTsyvgGkvrGlrvkvd
                      + l+ll++ll   ++ ++  ++  p    V T+   Gk+rG++ + +
   mKIAA1070    32    LTLCLLGCLLQTFHVLSQKLDDVDP---LVTTNF--GKIRGIKKELN 73   

                   g.gnkpvyaFlGIPYAkPPvGeLRFkkPqPypepWtgvldATkygpaCpQ
                   +++ +pv +FlG+PYA+PP+Ge+RF++P+P p+pW+++++AT+++p+CpQ
   mKIAA1070    74 NeILGPVIQFLGVPYAAPPTGEHRFQPPEP-PSPWSDIRNATQFAPVCPQ 122  

                   .ndlgfpgFslal.hv.gsemwnkntg......ksmSEDCLYLNVytPkl
                   ++  g      +l++v ++ ++  n+   ++  +++SEDCLYLN+y+P+ 
   mKIAA1070   123 nIIDG------RLpEVmLPVWFTNNLDvvssyvQDQSEDCLYLNIYVPTE 166  

                   asesk.......................klPVmVwIHGGGFqsGsassvt
                   + +  ++++++ +++++ ++++ ++++++ PVmV+IHGG +++G++    
   mKIAA1070   167 DGPLTkkhtddlgdndgaededirdsggPKPVMVYIHGGSYMEGTG---- 212  

                   lddydgpdlaasedVVVVtiNYRLGalGFLstgdselppppGNaGLlDQv
                    ++ydg++la++++V+V+t+NYRLG+lGFLstgd+ ++   GN+GLlD +
   mKIAA1070   213 -NLYDGSVLASYGNVIVITVNYRLGVLGFLSTGDQAAK---GNYGLLDLI 258  

                   lALrWVqeNIaaFGGDPdnVTlFGeSAGAaSVsllllS........ppqs
                   +ALrW  eNI +FGGDP ++T+FG +AG+++V+ll+lS+ +++++   ++
   mKIAA1070   259 QALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLShysegnrwSNST 308  

                   rGLFhrAIlqSGsalspwaits.pearnrakrlAkllGCpgedseelveC
                   +GLF+rAI qSG+als+wa++ +p   ++a+ lA+++GC+ +d  elveC
   mKIAA1070   309 KGLFQRAIAQSGTALSSWAVSFqP--AKYARILATKVGCNVSDTVELVEC 356  

                   LRkksaeelldaqwklllleefgffplfaFgPVvdGdtpdaflpkdPeel
                   L+kk+ +el+d++   +++++   f      PV+dGd    ++p+dP++l
   mKIAA1070   357 LQKKPYKELVDQDV--QPARYHIAFG-----PVIDGD----VIPDDPQIL 395  

                   lkegnfnkvPlliGvtsdEGllflayvl.dp.lsadllseidnedlflel
                   +++g f ++++++Gv++ EGl f+  + + ++ +    s +d+++   ++
   mKIAA1070   396 MEQGEFLNYDIMLGVNQGEGLKFVENIVdSDdGV----SASDFDF-AVSN 440  

                   lpellpgase.ltlklreeiadalkeeYtdd.dd.nseesrdalldllsD
                   ++++l+g++e++     + +++++k++Ytd+ d++n+e+ r+ ll l++D
   mKIAA1070   441 FVDNLYGYPEgK-----DVLRETIKFMYTDWaDRhNPETRRKTLLALFTD 485  

                   ylFvcPilrlaaaraakagapvYlYrFdyrssdsfnqylinllwppwrgv
                   +++v+P +++ a+ ++++g+p+Y+Y F +++         ++  p w  +
   mKIAA1070   486 HQWVAP-AVATADLHSNFGSPTYFYAFYHHCQ--------TDQVPAWADA 526  

                   sHgdelsYvFGnpls.k.ly....steeeeklssrrmmrywtnFAktGnP
                    Hgde++Yv+G p++++++  + ++++ + +ls +++m+ywtnFAktG+P
   mKIAA1070   527 AHGDEVPYVLGIPMIgPtELfpcnFSKNDVMLS-AVVMTYWTNFAKTGDP 575  

                   N.............ngessglpkWppytkeeqkyylpitllnisqk.lre
                   N++ +++++  +++++  ++++ W +y++++q  yl+i+l+++++ ++r+
   mKIAA1070   576 NqpvpqdtkfihtkPNR-FEEVAWTRYSQKDQ-LYLHIGLKPRVKEhYRA 623  

                   ldPrkvkcafw<-*
                   ++     +++w   
   mKIAA1070   624 NK-----VNLW    629  

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