hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mbh/mbh01281/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1060  ( 1115 res)   mbh01281

Scores for sequence family classification (score includes all domains):
Model         Description                               Score    E-value  N 
--------      -----------                               -----    ------- ---
Guanylate_cyc Adenylate and Guanylate cyclase catalyt   576.0   2.4e-169   2
DUF1053       Domain of Unknown Function (DUF1053)      188.3    1.2e-52   1
DUF939        Bacterial protein of unknown function (  -167.6       0.22   1

Parsed for domains:
Model         Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
--------      ------- ----- -----    ----- -----      -----  -------
DUF939          1/1     105   367 ..     1   360 []  -167.6     0.22
Guanylate_cyc   1/2     305   489 ..     1   223 []   246.0  5.2e-70
DUF1053         1/1     501   624 ..     1   127 []   188.3  1.2e-52
Guanylate_cyc   2/2     902  1102 ..     1   223 []   331.7  8.2e-96

Alignments of top-scoring domains:
DUF939: domain 1 of 1, from 105 to 367: score -167.6, E = 0.22
                   *->mkIGyRTiKTalattLAiiIAewLgLdyavSAGIiaILsIqpTkkrS
                                ++ t+LAi++A+++            +++I++  k  
   mKIAA1060   105    ----------TVPTALAIFFAIFI------------LVCIESVFKKL 129  

                   LqaaiqRllacvLalaiavvff..eLfGysPvviGlyllifIPLtvkLKv
                   L++    ++ c+ a+ + +++f++ +     v+++l +++++ +++ ++ 
   mKIAA1060   130 LRVFSLVIWICLVAMGYLFMCFggTVSAWDQVSFFLFIIFVVYTMLPFNM 179  

                   eeGivvSsVlsVlhllvsksENFisffMlllNEllLitvGvgvAlLvNlY
                    + i+ S ++s +h +v ++  + s +  ++  l+  ++  ++ ++    
   mKIAA1060   180 RDAIIASVLTSSSHTIVLSV--YLSATPGAKEHLFWQILANVIIFICGNL 227  

                   MLPPslekkLkeyqqkIEenlkeIlqeiayylRthesewkneedilkLie
                      + + k L e      ++ ++  + i++ + ++ ++ + e  +l+L++
   mKIAA1060   228 A--GAYHKHLME--LALQQTYRDTCNCIKSRIKLEFEKRQQERLLLSLLP 273  

                   eLdklIdkAkslAyRdvnNhffrtenyyyhYfeMReeQfFRQavktikka
                     +    kA+++       ++++         ++ ++ +           
   mKIAA1060   274 AHIAMEMKAEII-------QRLQGP-------KAGQMEN----------- 298  

                   LeiLkrMhphltsiidhtdeqQinideklsnlladl..teelaeqlgken
                          ++++ ++ + +  +        s+l ad+ ++  la+  +++ 
   mKIAA1060   299 -------TNNFHNL-YVKRHT------NVSILYADIvgFTRLASDCSPG- 333  

                   paadlleeldkryKerLrkeFWkekkreqnLPeTreeFlllEtRAmLfql
                       l++ l     ++L+ +F            +++ +   E+       
   mKIAA1060   334 ---ELVHML-----NELFGKF------------DQIAK---EN------- 353  

                   lneLEeyleiKssFytk<-*
                    + ++  ++i  ++y     
   mKIAA1060   354 -ECMR--IKILGDCYYC    367  

Guanylate_cyc: domain 1 of 2, from 305 to 489: score 246.0, E = 5.2e-70
                   *->vyaqrydnVtilFaDIvGFTalssrhsvNngpeevvrlLNdlytrFD
                      +y +r+ nV+il aDIvGFT+l+s +s    p e+v +LN+l+++FD
   mKIAA1060   305    LYVKRHTNVSILYADIVGFTRLASDCS----PGELVHMLNELFGKFD 347  

                   eLldehkfgvyKvKTIGDaYMvasGlppaadqtkLakklqldsaaHaakl
                    ++ e+   + ++K++GD+Y+++sGlp                + Ha  +
   mKIAA1060   348 QIAKEN--ECMRIKILGDCYYCVSGLPIS-------------LPNHAKNC 382  

                   adfALdmveaiqevnvehanrepPtvLyrGlrvRiGiHtGpVvaGviGlt
                   + ++Ldm eai++v+  +++  +       +++R+G+H+G V++GviG  
   mKIAA1060   383 VKMGLDMCEAIKKVRDATGV--D-------INMRVGVHSGNVLCGVIG-- 421  

                   akrprYdvwGdTVNlASRmEStGvpgsekIhvseetyrlLkeeesfefef
                   +++++Ydvw+++V+lA+ mE++Gvpg  ++h+s  t + L++ + +e + 
   mKIAA1060   422 LQKWQYDVWSHDVTLANHMEAGGVPG--RVHISSVTLEHLNGAYKVEEG- 468  

                   aleprgeveVkGkgkpGeietYfLkg<-*
                        ge+  + +++   ++tYf+++   
   mKIAA1060   469 ----DGEIRDPYLKQH-LVKTYFVIN    489  

DUF1053: domain 1 of 1, from 501 to 624: score 188.3, E = 1.2e-52
                   *->knnksqskvadkrrsvsmtrylesWgperPFanLnsresglsaatsi
                       ++++++++a++r+sv+mtrylesWg+++PFa+L++r+s+++++ +i
   mKIAA1060   501    FRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKI 547  

                   lfkrpfrkrhsvaahhqptlhskKgrdEleevdeFlsQAInarSvdcdcw
                   ++ + ++ +h++++++ +t+++kK+++  ee +e++ QAI++ + +++ w
   mKIAA1060   548 STTDVPMGQHNFQNRTLRTKSQKKRFE--EELNERMIQAIDGINAQKQ-W 594  

                   kksEhvdrlTLrFrqsdmEreYhkdfdlgF<-*
                   +ksE+++r++L F+++++E+eY+ +++++F   
   mKIAA1060   595 LKSEDIQRISLFFYNKNIEKEYRATALPAF    624  

Guanylate_cyc: domain 2 of 2, from 902 to 1102: score 331.7, E = 8.2e-96
                   *->vyaqrydnVtilFaDIvGFTalssrhsvNngpeevvrlLNdlytrFD
                      +y+q+yd+V+++Fa+I++F +++++++vN++++e++rlLN+++++FD
   mKIAA1060   902    LYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFD 948  

                   eLldehkf.gvyKvKTIGDaYMvasGlppaadqt..........kLakkl
                   +Ll+++kf+gv+K+KTIG++YM+a Gl+     ++++++ +++++     
   mKIAA1060   949 DLLSKPKFsGVEKIKTIGSTYMAATGLSA----VpsqehaqepeR----- 989  

                   qldsaaHaakladfALdmveaiqevnvehanrepPtvLyrGlrvRiGiHt
                      +++H+ ++++fA ++v  ++ +n++++n  +       +++R+Gi++
   mKIAA1060   990 ---QYMHIGTMVEFAYALVGKLDAINKHSFN--D-------FKLRVGINH 1027 

                   GpVvaGviGltakrprYdvwGdTVNlASRmEStGvpgsekIhvseetyrl
                   GpV+aGviG  a++p+Yd+wG+TVN+ASRm+StGv    kI+v+eet  +
   mKIAA1060  1028 GPVIAGVIG--AQKPQYDIWGNTVNVASRMDSTGVLD--KIQVTEETSLI 1073 

                   LkeeesfefefaleprgeveVkGkgkpGeietYfLkg<-*
                   L++++ +++++    rg+++VkGkg    ++tYf++    
   mKIAA1060  1074 LQTLG-YTCTC----RGIINVKGKGD---LKTYFVNT    1102 

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