hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mph/mph01913/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1010  ( 836 res)   mph01913

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RhoGEF   Guanine nucleotide exchange factor for Rho/R   141.4    9.5e-38   1
SH3      Src homology 3 domains                          67.3    1.9e-15   2

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RhoGEF     1/1      47   225 ..     1   211 []   141.4  9.5e-38
SH3        1/2     547   606 ..     1    58 []    10.0     0.79
SH3        2/2     775   834 ..     1    58 []    57.4  1.9e-12

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 47 to 225: score 141.4, E = 9.5e-38
                   *->vlkELlqTErnYVrdLkilvevflkpLkkeakssllpllspdevktl
                      v+ ELlqTEr+Y+rdL++++e  + pL++ +       +++ +++ l
   mKIAA1010    47    VVAELLQTERDYIRDLEMCIERVMVPLQQAQ-------VPNVDFEGL 86   

                   FgpNieeiyefHrrFLdeLeerveewllskdlKsernsviedsgerigdv
                   Fg N+++++++++++L++Le                        + +g v
   mKIAA1010    87 FG-NMQTVIKVSKQLLAALEIS----------------------DAVGPV 113  

                   FlklfsaeeffkiYseYcsnhpdalellkkLmkkkknpaFqkflkei...
                   Fl++  + e+  +Y  Yc+nh++a++ll+  +  +k+++ qk+l+    +
   mKIAA1010   114 FLDH--RDELEGTYRVYCQNHDEAISLLEM-Y--EKDEKTQKHLQDYlad 158  

                   eskpncr.sk.searltLeslLikPvQRltkYpLLLkellkhtppdhedr
                    ++ +++ + +      L s+LikPvQR+++YpLLL ell  tp++h+d+
   mKIAA1010   159 LKSLYHEwGCtN--YINLGSFLIKPVQRIMRYPLLLMELLNSTPESHPDK 206  

                   edLkkAleaikelasqvNe<-*
                     L+ A+ a+ke+   +Ne   
   mKIAA1010   207 VPLTNAVLAVKEINVNINE    225  

SH3: domain 1 of 2, from 547 to 606: score 10.0, E = 0.79
                   *->eyvvAlYDyeaqnedELsFkkGDiitvleks....ddgWweGelnrt
                      + + ++ +++a ++ + s+ +GD + v++k ++ ++++ w + ++  
   mKIAA1010   547    KLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKdpmgSQNRWLVDNG-- 591  

                   GkeGlfPsnYVeeie<-*
                     +G++ s+++++++   
   mKIAA1010   592 VTKGFVYSSFLKPYN    606  

SH3: domain 2 of 2, from 775 to 834: score 57.4, E = 1.9e-12
                   *->eyvvAlYDyeaqnedELsFkkGDiitvleks....ddgWweGelnrt
                      +++ A+Y ++a+n++ELs+ +++ ++++e  + +++ +Ww +e+n  
   mKIAA1010   775    QVYFAIYTFKARNPNELSVLANQRLRIHEFKdvtgNTEWWLAEVN-- 819  

                   GkeGlfPsnYVeeie<-*
                   G++G++PsnY+++ e   
   mKIAA1010   820 GRKGYVPSNYIRKTE    834  

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