hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/Pfam
Sequence file:            /cdna4/rodent/full/goal/mph/mph01913/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA1010  ( 836 res)   mph01913

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
BAR      BAR domain                                     235.9    5.7e-67   1
RhoGEF   RhoGEF domain                                  120.2      4e-32   1
SH3_2    Variant SH3 domain                              63.9    3.4e-15   2
SH3_1    SH3 domain                                      52.6    8.7e-12   2

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RhoGEF     1/1      47   225 ..     1   207 []   120.2    4e-32
BAR        1/1     256   466 ..     1   264 []   235.9  5.7e-67
SH3_1      1/2     547   605 ..     1    58 []     0.6     0.14
SH3_2      1/2     548   605 ..     1    69 []    30.5    4e-05
SH3_1      2/2     775   833 ..     1    58 []    52.0  1.3e-11
SH3_2      2/2     776   833 ..     1    69 []    33.5    5e-06

Alignments of top-scoring domains:
RhoGEF: domain 1 of 1, from 47 to 225: score 120.2, E = 4e-32
                   *->vlkElleTEkkYvrdLeildnvymkpLreaaisskpvltpddietiF
                      v++Ell+TE+ Y+rdLe+ +   m pL++a+      ++  d e +F
   mKIAA1010    47    VVAELLQTERDYIRDLEMCIERVMVPLQQAQ------VPNVDFEGLF 87   

                   sNiediyefhreFLkssLearisssqfedlDekkiepsaqrlGdlFlklk
                   +N+ + +++ +++L  +Le+   +                  G++Fl++ 
   mKIAA1010    88 GNMQTVIKVSKQLLA-ALEISDAV------------------GPVFLDHR 118  

                   epflqvYgeYcsnkpyAqelleklrqaasnpqFaefldeveassntgAkd
                   ++  + Y+ Yc+n++ A+ lle+    ++ ++ ++ l+++ a  ++   +
   mKIAA1010   119 DELEGTYRVYCQNHDEAISLLEM---YEKDEKTQKHLQDYLAD-LKSLYH 164  

                   ...davkltLqsLLlkPvqRilrYpLLLkeLLkhtpegedqpdredLkka
                   + + +    L s+L+kPvqRi rYpLLL eLL  tpe  ++pd++ L  a
   mKIAA1010   165 ewgCTNYINLGSFLIKPVQRIMRYPLLLMELLNSTPE--SHPDKVPLTNA 212  

                   ldllqdlaksiNe<-*
                     +++++   iNe   
   mKIAA1010   213 VLAVKEINVNINE    225  

BAR: domain 1 of 1, from 256 to 466: score 235.9, E = 5.7e-67
                   *->lkKqAGgffnRasqllkeKvGkaekTkvLDedFeelerrfdtteklv
                      + K+    ++R+s +lk+ +G+a + k  De+Fee e++f+++e+l+
   mKIAA1010   256    IIKK----SSRVSSHLKHLTGFAPQLK--DEVFEETEKNFRMQERLI 296  

                   kklvketklYlqpnpaarakqkvleklskrrgqvkrkgypqPetlLaetm
                   k+++++++lYlq+++++ + ++                      + a+++
   mKIAA1010   297 KSFIRDLSLYLQHIRESACVKV----------------------VAAMSI 324  

                   qeigeelgddsedPfGkaLekygeamkql.aqlleqldervkqnfldPlt
                   +++++e g+ ++       e+++++++++++ql+  ++er++++++ Pl+
   mKIAA1010   325 WDLCMERGHHDL-------EQFEKVHRYIsDQLFTRFKERTERLVINPLN 367  

                   nllekefkeiqkhikKlerKrLDyDakrtrlkkaktkkskkakDekklak
                   +ll ++f+++ k+++K+ +K+LD++++ +r +k+k+kk+           
   mKIAA1010   368 QLL-NMFTGPYKLVQKRFDKLLDFYNCTERAEKLKDKKT----------- 405  

                   AdqleeElrqAqqkfEelneeLkeeLpnlleleveflvnqlqafveaqld
                        eEl+ A++++E+ln +L++eLp++ +++++ ++n+ ++++ea++d
   mKIAA1010   406 ----LEELQSARNNYEALNSQLLDELPKFQQYAQSLFTNCIHGYAEAHCD 451  

                   fhrqsaqlleqlqqqLdk<-*
                   f +q+   leqlq+ L++   
   mKIAA1010   452 FVQQA---LEQLQPLLSL    466  

SH3_1: domain 1 of 2, from 547 to 605: score 0.6, E = 0.14
                   *->kkvvALYDYearesdELsFkkGDvitvleksdd....gWWkgrlkgt
                      k + +   ++a ++ ++s+ +GD + v++k+d  ++++ W + +  t
   mKIAA1010   547    KLFHVQRNFNAAQDLDVSLLEGDLVGVIKKKDPmgsqNRWLVDNGVT 593  

                   gGkeGliPsNYVepv<-*
                      +G++ s+++ p+   
   mKIAA1010   594 ---KGFVYSSFLKPY    605  

SH3_2: domain 1 of 2, from 548 to 605: score 30.5, E = 4e-05
                   *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskddd....
                      ++ + ++++a +   +       sl +Gd+v vi    +k+d+ +++
   mKIAA1010   548    LFHVQRNFNA-AQDLD------VSLLEGDLVGVI----KKKDPmgsq 583  

                   gwwlgeslggGrrrRGlvPssaveel<-*
                   + wl+++  g  +  G+v+ss+++++   
   mKIAA1010   584 NRWLVDN--GVTK--GFVYSSFLKPY    605  

SH3_1: domain 2 of 2, from 775 to 833: score 52.0, E = 1.3e-11
                   *->kkvvALYDYearesdELsFkkGDvitvleksdd....gWWkgrlkgt
                      +++ A+Y ++ar+++ELs   +  + ++e +d +++++WW ++++  
   mKIAA1010   775    QVYFAIYTFKARNPNELSVLANQRLRIHEFKDVtgntEWWLAEVN-- 819  

                   gGkeGliPsNYVepv<-*
                    G++G++PsNY+++    
   mKIAA1010   820 -GRKGYVPSNYIRKT    833  

SH3_2: domain 2 of 2, from 776 to 833: score 33.5, E = 5e-06
                   *->ygraiedyvaAtdknenleeeeLslkkGdvvkvidvggskddd.gww
                      ++ ai  ++a +++ne      Ls+ +++ +++  ++++   +++ww
   mKIAA1010   776    VYFAIYTFKA-RNPNE------LSVLANQRLRIH-EFKDVTGNtEWW 814  

                   lgeslggGrrrRGlvPssaveel<-*
                   l+e+  +Gr+  G+vPs+++++    
   mKIAA1010   815 LAEV--NGRK--GYVPSNYIRKT    833  

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