hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg08419/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0973 ( 1202 res) mbg08419 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Pkinase Protein kinase domain 268.5 8.6e-77 1 PDZ PDZ domain (Also known as DHR or GLGF) 43.3 5.3e-09 1 Pkinase_C Protein kinase C terminal domain 29.4 8.2e-05 1 APH Phosphotransferase enzyme family -11.4 0.22 1 Pkinase_Tyr Protein tyrosine kinase -24.5 2.4e-10 1 RIO1 RIO1 family -101.7 0.42 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- RIO1 1/1 69 213 .. 1 203 [] -101.7 0.42 APH 1/1 58 241 .. 1 256 [] -11.4 0.22 Pkinase_Tyr 1/1 56 315 .. 1 272 [] -24.5 2.4e-10 Pkinase 1/1 56 329 .. 1 287 [] 268.5 8.6e-77 Pkinase_C 1/1 347 392 .. 1 47 [] 29.4 8.2e-05 PDZ 1/1 649 734 .. 1 82 [] 43.3 5.3e-09 Alignments of top-scoring domains: RIO1: domain 1 of 1, from 69 to 213: score -101.7, E = 0.42 *->nVYhAvsyaedgedptevAv.KiyrtgtteFkkrkkYrdgdfRFrdr +VY ++ d + +A++Ki + + ++ +++ f rd+ mKIAA0973 69 AVYLVRH--RDTRQ--RFAMkKINKQNLI----LRNQIQQAFVERDI 107 ksktswrklvrlWAeKEfrN.LkRLyeaGvpVPkPiavnrh.vLVMEfIg + Ae f ++ + e +rh + VME++ mKIAA0973 108 ----------LTFAENPFVVgMFCSFET----------RRHlCMVMEYVE 137 dedGvpAPrLkdveleldlseeeaeelYdeiirEymrrlYkeagLVHGDL G+ A Lk++ l+ e a+ +++e++ +++ g+VH DL mKIAA0973 138 --GGDCATLLKNIGA---LPVEMARMYFAETVL--ALEYLHNYGIVHRDL 180 SEYNiLvhddgkpviIDvsQaVetdHPnAlefLeRDieNIinFFrrkgvd N+L++ g++ + D++ +++g + mKIAA0973 181 KPDNLLITSMGHIKLTDFG------------------------LSKMGLM 206 krvvdvrel<-* +++++ + mKIAA0973 207 --SLTTNLY 213 APH: domain 1 of 1, from 58 to 241: score -11.4, E = 0.22 *->elrplsgGasnrtylvttgd.gdapryvlrlappgeaaeelerEaav +++ +s Ga +++ylv++ d++ +r+ + +++ +l ++ mKIAA0973 58 TIKLISNGAYGAVYLVRHRDtR--QRFAMKKINKQ----NLILRNQI 98 lrhLaalgipvpvpvPrvlaggtdgeglgl.....pfllleglpGevlsr +++ +++i + P v++ ++ +++++++ ++e+++G + ++ mKIAA0973 99 QQAFVERDILTFAENPFVVG-----MFCSFetrrhLCMVMEYVEGGDCAT 143 pnalspaerpallealarlLarLHqvdppalplarrlerrlkllrqlaaa l ++++ ++ +r a+ mKIAA0973 144 -------------------------------LLKNIGALPVEMARMYFAE 162 larlvaaelldeerglllelaerllaaleallpppvlvHGDlhpgNvlvd +a+e+l ++vH+Dl p+N+l++ mKIAA0973 163 --TVLALEYLH----------------------NYGIVHRDLKPDNLLIT 188 dapdggrvsGvIDfedaglGdpayDlAmllrslfgeefgpefldaylaay + g + Df+ + +G l +l +l+ + + ++ + + mKIAA0973 189 --SMGHIK--LTDFGLSKMG-----LMSLTTNLYEGHIEKDAREFLDKQV 229 grqfaapglerlrel<-* + + p++ + + + mKIAA0973 230 C---GTPEYIAPEVI 241 Pkinase_Tyr: domain 1 of 1, from 56 to 315: score -24.5, E = 2.4e-10 *->lklgkkLGeGaFGeVykGtlkgsgegtkikVAVKtL.ke.igassee + +k + Ga+G Vy+ + + +t++ A K+++k+++ + mKIAA0973 56 FDTIKLISNGAYGAVYLVRHR----DTRQRFAMKKInKQnLILRNQI 98 ieredFlrEAsiMkklGdHpNiVrLlGvctkegePggpglyiVtEymegG +++F + + ++ +p +V + + ++++ l++V+Ey+egG mKIAA0973 99 --QQAFVE--RDILTFAENPFVVGMF-CSFETRRH----LCMVMEYVEGG 139 dLldfLrkhregrpLtlkdLlsfalQiAkGMeYLesknfvHRDLAARNcL d + L++ ++L++++ + ++ ++eYL++ ++vHRDL N L mKIAA0973 140 DCATLLKN---IGALPVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLL 186 VsenlvVKIsDFGLaRdiynddyYvrkkgggklPv............... +++ +++K +DFGL++ ++ l + +++ +++ ++ mKIAA0973 187 ITSMGHIKLTDFGLSKMG-------LMS----LTTnlyeghiekdarefl 225 ........kWmAPEslkygkFtskSDVWSFGVlLWEiftlGeqPFYpgms +++ +++ APE++ + D W+ G+ L+E + + P + g + mKIAA0973 226 dkqvcgtpEYIAPEVILRQGYGKPVDWWAMGIILYEFLVGC-VP-FFGDT 273 neevlellyedGyRL.....prPenCPdelYdlMlqCWaedPedRPtFse +ee++ ++ ++ L ++++++ P + l+ + + +P mKIAA0973 274 PEELFGQV-ISDDILwpegdEAL---PTDAQLLISSLLQTNP-------- 311 lverL<-* + rL mKIAA0973 312 -LVRL 315 Pkinase: domain 1 of 1, from 56 to 329: score 268.5, E = 8.6e-77 *->yelleklGsGsfGtVykakhkgtgkiVAvKiikkr.kekskkdktar + +++ + G++G Vy+ +h++t++++A+K+i+k++ + ++ ++a+ mKIAA0973 56 FDTIKLISNGAYGAVYLVRHRDTRQRFAMKKINKQnLILRNQIQQAF 102 rrsEiqilkrLsHpNIvrlidvfedkdhlylVlEycegGLrlldLfdyls E il p++v ++++fe+++hl++V+Ey+egG d ++l+ mKIAA0973 103 V--ERDILTFAENPFVVGMFCSFETRRHLCMVMEYVEGG----DCATLLK 146 etrrkgpllfsedeakkialQilrgleYLHsngiiHRDLKPeNILldeng + g+l + + a++++ +++ +leYLH+ gi+HRDLKP+N+L+ + g mKIAA0973 147 ---NIGAL--PVEMARMYFAETVLALEYLHNYGIVHRDLKPDNLLITSMG 191 vvdaflKiaDFGlAkkls............t.sss.l..ttfvGTpwYmA ++ K++DFGl+k + +++ +++ ++ +++ ++ ++GTp+Y+A mKIAA0973 192 HI----KLTDFGLSKMGLmslttnlyeghiEkDAReFldKQVCGTPEYIA 237 PEvllggngygtkvDvWSlGvilyelltGkpPFsgevqdsldqlqlirki PEv+l ++gyg++vD+W++G+ilye+l G PF g+ ++ +l+ ++ mKIAA0973 238 PEVIL-RQGYGKPVDWWAMGIILYEFLVGCVPFFGD-----TPEELFGQV 281 lgpplefdspewdsisrsefrrlpnlseeakdLikkcLnkDPskRlt... + + +++ + +l+ +a+ Li+++L+ +P Rl+ ++ mKIAA0973 282 ISDDILWPEGDE------------ALPTDAQLLISSLLQTNPLVRLGagg 319 aeeilqHPwf<-* a e++qH +f mKIAA0973 320 AFEVKQHSFF 329 Pkinase_C: domain 1 of 1, from 347 to 392: score 29.4, E = 8.2e-05 *->kvksptDTsNFDpeFTsepptltpppdsr.lssgkqleFvGFtYvnp +++s++DTs+FD+ ++++++ + d+++ ++++ e ++F+ ++p mKIAA0973 347 HLESEDDTSYFDTRSDRYHHVNS--YDEDdTTEEEPVEIRQFSSCSP 391 e<-* mKIAA0973 392 R 392 PDZ: domain 1 of 1, from 649 to 734: score 43.3, E = 5.3e-09 *->evtlekevkrgglGfsikggsdk.........givvsevlpGsgaAe +t+++ ++ + Gf+++ ++++ + + +v +v +G g+A+ mKIAA0973 649 PITIQR--SGKKYGFTLRAIRVYmgdsdvysvHHIVWHVEEG-GPAQ 692 agGrLkeGDqIlsvNGqdvenlsheravlalkgsggsevtLtil<-* +G L++GD I+ vNG++v ++ h ++v+++ +sg+ +v++t mKIAA0973 693 EAG-LCAGDLITHVNGEPVHGMVHPEVVELILKSGN-KVAVTTT 734 //