hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg05450/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0921 ( 1555 res) mbg05450 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Laminin_G_2 Laminin G domain 659.0 2.5e-194 6 Laminin_G_1 Laminin G domain 267.7 1.5e-76 5 EGF EGF-like domain 51.8 1.5e-11 3 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Laminin_G_2 1/6 102 232 .. 1 141 [] 117.2 3.1e-31 Laminin_G_1 1/5 102 235 .. 1 154 [] 66.2 6.9e-16 EGF 1/3 251 286 .. 1 39 [] 19.7 0.069 Laminin_G_2 2/6 363 497 .. 1 141 [] 117.6 2.4e-31 Laminin_G_1 2/5 363 500 .. 1 154 [] 44.9 1.8e-09 Laminin_G_2 3/6 559 704 .. 1 141 [] 149.5 6e-41 Laminin_G_1 3/5 559 707 .. 1 154 [] 81.3 1.9e-20 EGF 2/3 732 764 .. 1 39 [] 20.7 0.035 Laminin_G_2 4/6 798 928 .. 1 141 [] 88.9 1e-22 Laminin_G_1 4/5 798 931 .. 1 154 [] 6.8 0.0027 Laminin_G_2 5/6 984 1112 .. 1 141 [] 145.5 9.1e-40 Laminin_G_1 5/5 984 1115 .. 1 154 [] 81.4 1.8e-20 EGF 3/3 1138 1170 .. 1 39 [] 27.2 0.00038 Laminin_G_2 6/6 1207 1355 .. 1 141 [] 63.4 4.7e-15 Alignments of top-scoring domains: Laminin_G_2: domain 1 of 6, from 102 to 232: score 117.2, E = 3.1e-31 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl +RT + +lLly+ ++++ +d fl L LvdGrl+lr+ l mKIAA0921 102 LRT-NATRALLLYLDDGgD--------CD-FLELLLVDGRLRLRFTL 138 Gsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgssd ++++l +++++D +WH V ++r+ r+ L VDg+ + + ++ mKIAA0921 139 SCAEpATLQLDtPVADDRWHMVLLTRDARRTALAVDGEaRAaEvRSKRR- 187 tlslnlngplylGGlpessksslltltaaqnlvvvs.gFvGCirdvring +++ ++l++GG+p++ ++s+ltl +++ ++F+G + +++++ mKIAA0921 188 --EMQVASDLFVGGIPPDVRLSALTLSTVKY----EpPFRGLLANLKLGE 231 e<-* + mKIAA0921 232 R 232 Laminin_G_1: domain 1 of 5, from 102 to 235: score 66.2, E = 6.9e-16 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl RT ++ +lLl Y+++ d DFl l LvdGrl++++ l mKIAA0921 102 LRTNATRALLL--YLDDGGDC--------DFLELLLVDGRLRLRFTL 138 GsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdgeervvdges + +pa++ ++ ++D +WH+v l+r r+ L Vdge+r e mKIAA0921 139 SCA---EPATLQLDTP-VADDRWHMVLLTRDARRTALAVDGEAR--AAEV 182 psgpditsenLdldtppiLyvGGlPel..qksvkrrlaaistsFkGCird s++ ++ L+vGG+P++ + + + + ++F+G + + mKIAA0921 183 RSKRRE----MQVASD--LFVGGIPPDvrLSALTLSTVKYEPPFRGLLAN 226 vsingkpld<-* ++++++p mKIAA0921 227 LKLGERPPA 235 EGF: domain 1 of 3, from 251 to 286: score 19.7, E = 0.069 *->CspnngpCsngGtCvdtpg.gytCeCppGdyfllytGkrC<-* C+p +pC ngG C+ + ++ C+C + ++ Gk+C mKIAA0921 251 CAPARNPCANGGLCTVLAPgEVGCDCSHT----GFGGKFC 286 Laminin_G_2: domain 2 of 6, from 363 to 497: score 117.6, E = 2.4e-31 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl FRT q nGl+l++g + + ++ L+L+ G + l+++l mKIAA0921 363 FRT-LQRNGLMLHTGKSaD-----------YVNLSLKSGAVWLVINL 397 G..sgg.vlltsg.klnDGqWHtVsverngrs........vtLsVDgg.v G++ + ++ ++k+nD+ WH+V+v+rn r++ + ++ vt+sVDg + mKIAA0921 398 GsgAFEaLVEPVNgKFNDNAWHDVRVTRNLRQhagighamVTISVDGIlT 447 v.g.spgssdtlslnlngplylGGlpessksslltltaaqnlvvvs.gFv +g +++ + +l + +y+GG p+ +++++ ++ s++F mKIAA0921 448 TtGyTQEDYT--MLGSDDFFYIGGSPNTADLPGSPV---------SnNFM 486 GCirdvringe<-* GC++dv++ ++ mKIAA0921 487 GCLKDVVYKNN 497 Laminin_G_1: domain 2 of 5, from 363 to 500: score 44.9, E = 1.8e-09 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl FRT + +Gl l t + + D++ l L G + + +l mKIAA0921 363 FRTLQRNGLML----HTGKSA--------DYVNLSLKSGAVWLVINL 397 GsghrlrpavvrsgdrvlnDGkWHrvelerngrk........gtLsVdge Gsg ++ v ++++ +nD+ WH v ++rn r++ + ++ +t+sVdg mKIAA0921 398 GSG-AFEALVEPVNGK-FNDNAWHDVRVTRNLRQhagighamVTISVDGI 445 ervvdgespsgpditsenLdldtppiLyvGGlPelqksvkrrlaaistsF ++ ++++ ++++ L d+ +y+GG P ++ ++ ++s F mKIAA0921 446 LTTTGYTQE-DYTM----LGSDDF--FYIGGSP---NTADLPGSPVSNNF 485 kGCirdvsingkpld<-* GC++dv+ + mKIAA0921 486 MGCLKDVVYKNNDFK 500 Laminin_G_2: domain 3 of 6, from 559 to 704: score 149.5, E = 6e-41 *->FRTatqpnGlLlyaggk.g...lp.dtadpksdKflaLeLvdGrlvl FRT t+pnGlLl++ g++ + + ++++++++ d ++a eL dG+l+l mKIAA0921 559 FRT-TEPNGLLLFSQGRrAgagVGsHSSTQRAD-YFAMELLDGYLYL 603 rydlGsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.sp +d+Gsgg l s++k+nDG+W +V + r+gr++++sV+ +++ + mKIAA0921 604 LLDMGSGGiKLRASSrKVNDGEWCHVDFQRDGRKGSISVNSRsTPfLaTG 653 gssdtlslnlngplylGGlpessksslltltaaqn.lvvvs.gFvGCird +s+ l+l+++lylGGlpe++++ l++++ +++ + + g+vGC+rd mKIAA0921 654 ESE---VLDLESELYLGGLPEGGRVDLPLPPEVWTaAL--RaGYVGCVRD 698 vringe<-* ++i+g+ mKIAA0921 699 LFIDGR 704 Laminin_G_1: domain 3 of 5, from 559 to 707: score 81.3, E = 1.9e-20 *->FRTtepsGlLllgYnGtntdrrg....kkeigdDFlaleLvdGrlev FRTtep+GlLl ++ ++g +++ + D++a eL dG l++ mKIAA0921 559 FRTTEPNGLLL--FSQGRRAGAGvgshSSTQRADYFAMELLDGYLYL 603 sydlGsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdgeervv +d Gsg + +r+ r++nDG+W +v r grkg++sV+ + mKIAA0921 604 LLDMGSG----GIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRST-- 647 dgespsgpditsenLdldtppiLyvGGlPel.qksvkrrl....aaists p+ ++++se Ldl+ + Ly+GGlPe + + +++ +aa + + mKIAA0921 648 ----PFLATGESEVLDLESE--LYLGGLPEGgRVDLPLPPevwtAALRAG 691 FkGCirdvsingkpld<-* ++GC+rd+ i+g+ d mKIAA0921 692 YVGCVRDLFIDGRSRD 707 EGF: domain 2 of 3, from 732 to 764: score 20.7, E = 0.035 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C++ pC ngG+C+++++ + C+C ++ G+ C mKIAA0921 732 CASA--PCRNGGICREGWNRFVCDCIGT----GFLGRVC 764 Laminin_G_2: domain 4 of 6, from 798 to 928: score 88.9, E = 1e-22 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl F ++ Gl++ + ++++ d l LeL +G+ +l+++l mKIAA0921 798 FMS-QRAYGLMMATTSReS--------AD-TLRLELDGGQMRLTVNL 834 G........sgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv. + + +s+g+ +l+ g+klnD++WHtV+v+r+g+s++LsVD+ +v + mKIAA0921 835 DclrvgcapSKGpETLFAGhKLNDNEWHTVRVVRRGKSLQLSVDNVtVEg 884 g.spgssdtlslnlngp.lylGGlpessksslltltaaqnlvvvs.gFvG + ++ ++ l+ + + G+ +++ +++ ++F G mKIAA0921 885 QmAGAHT---RLEFHNIeT---GIMTERRFISVV----------PsNFIG 918 Cirdvringe<-* ++++++ng+ mKIAA0921 919 HLSGLVFNGQ 928 Laminin_G_1: domain 4 of 5, from 798 to 931: score 6.8, E = 0.0027 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl F Gl + +t + + D l leL +G+ +++++l mKIAA0921 798 FMSQRAYGLMM----ATTSRESA------DTLRLELDGGQMRLTVNL 834 .........GsghrlrpavvrsgdrvlnDGkWHrvelerngrkgtLsVdg + + + +++g p+++++g + lnD++WH+v ++r g++++LsVd+ mKIAA0921 835 dclrvgcapSKG----PETLFAGHK-LNDNEWHTVRVVRRGKSLQLSVDN 879 eervvdgespsgpditsenLdldtppiLyvGGlPelqksvkrrlaaists v g + g+++ e+ + +t +++ r + ++ + mKIAA0921 880 VT--VEGQMA-GAHTRLEFHNIETG--------I---MTERRFISVVPSN 915 FkGCirdvsingkpld<-* F G + +++ng+p+ mKIAA0921 916 FIGHLSGLVFNGQPYM 931 Laminin_G_2: domain 5 of 6, from 984 to 1112: score 145.5, E = 9.1e-40 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl F+T t+p+GlLl+++g+++ d f+ +eLv G++++++dl mKIAA0921 984 FKT-TAPDGLLLFNSGNgN---------D-FIVIELVKGYIHYVFDL 1019 G.sgg.vlltsg.klnDGqWHtVsverngrs.vtLsVDggvv.g.spgss G+++ + s++++nD+qWH+V+v+r+ ++ tL++D ++v+++s g mKIAA0921 1020 GnGPSlMKGNSDkPVNDNQWHNVVVSRDPGNvHTLKIDSRTVtQhSNGAR 1069 dtlslnlngplylGGlpessksslltltaaqnlvvvs.gFvGCirdvrin +l+l+g+ly+GGl ++++s+l++l a ++gF+GC+ +v +n mKIAA0921 1070 ---NLDLKGELYIGGLSKNMFSNLPKLVAS------RdGFQGCLASVDLN 1110 ge<-* g+ mKIAA0921 1111 GR 1112 Laminin_G_1: domain 5 of 5, from 984 to 1115: score 81.4, E = 1.8e-20 *->FRTtepsGlLllgYnGtntdrrgkkeigdDFlaleLvdGrlevsydl F+Tt+p+GlLl + ++ DF+++eLv+G +++ +dl mKIAA0921 984 FKTTAPDGLLL---FNSGNGN--------DFIVIELVKGYIHYVFDL 1019 Gsghrlrpavvr..sgdrvlnDGkWHrvelerngrkg.tLsVdgeervvd G+g p + ++s ++ +nD++WH v+++r +++tL++d mKIAA0921 1020 GNG----PSLMKgnSDKP-VNDNQWHNVVVSRDPGNVhTLKIDSRT---- 1060 gespsgpditsenLdldtppiLyvGGlPelqksvkrrlaaistsFkGCir +++ s ++ nLdl+++ Ly+GGl ++ +s +++l a++++F GC+ mKIAA0921 1061 VTQHSNGAR---NLDLKGE--LYIGGLSKNMFSNLPKLVASRDGFQGCLA 1105 dvsingkpld<-* +v++ng++ d mKIAA0921 1106 SVDLNGRLPD 1115 EGF: domain 3 of 3, from 1138 to 1170: score 27.2, E = 0.00038 *->CspnngpCsngGtCvdtpggytCeCppGdyfllytGkrC<-* C+++ C n G C++ ++g+tC+C++ +y G+ C mKIAA0921 1138 CTEE--SCANQGVCLQQWDGFTCDCTMT----SYGGPVC 1170 Laminin_G_2: domain 6 of 6, from 1207 to 1355: score 63.4, E = 4.7e-15 *->FRTatqpnGlLlyaggk.glpdtadpksdKflaLeLvdGrlvlrydl F T q +++L + +++g +d +l+L + +G++ + ++ mKIAA0921 1207 FST-HQRSAVLVRVDSAsG-------LGD-YLQLHIDQGTVGVIFNV 1244 Gsgg.vlltsg.klnDGqWHtVsverngrsvtLsVDgg.vv.g.spgssd G+++ ++ ++ ++DG+ H V+++r+g+++tL+VD +v+++ + g++d mKIAA0921 1245 GTDDiTIDEPNaIVSDGKYHVVRFTRSGGNATLQVDSWpVNeRyPAGNFD 1294 tl.............................slnlngplylGGlpessks + +++ + + ++ ++ +++++ +++n + + +GG mKIAA0921 1295 NErlaiarqripyrlgrvvdewlldkgrqltIFNSQAAIKIGGRDQ---- 1340 slltltaaqnlvvvs.gFvGCirdvringe<-* ++F+G ++++++ng mKIAA0921 1341 --------------GrPFQG-VSGLYYNGL 1355 //