hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mfj/mfj07143/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0859 ( 713 res) mfj07143 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- Methyltransf_11 Methyltransferase domain 45.9 8.9e-10 2 Methyltransf_12 Methyltransferase domain 36.2 7.6e-07 2 TPMT Thiopurine S-methyltransferase (TPMT) -65.4 0.016 1 Spermine_synth Spermine/spermidine synthase -108.0 0.88 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- Methyltransf_12 1/2 68 171 .. 1 100 [] 28.5 0.00016 Methyltransf_11 1/2 68 173 .. 1 99 [] 40.9 2.9e-08 TPMT 1/1 27 227 .. 1 230 [] -65.4 0.016 Methyltransf_12 2/2 514 625 .. 1 100 [] 7.7 0.56 Methyltransf_11 2/2 514 627 .. 1 99 [] 5.1 0.21 Spermine_synth 1/1 430 673 .. 1 337 [] -108.0 0.88 Alignments of top-scoring domains: Methyltransf_12: domain 1 of 2, from 68 to 171: score 28.5, E = 0.00016 *->LdiGcGtGrllaalleallnpgaeytgvDiSp.aleiaaaaerladl L iGcG l+ l + + +++ +DiS+ + ++++++ mKIAA0859 68 LVIGCGNSELSEQLYDV---GYQDIVNIDISEvVI------KQMKER 105 gl.va.rvrldvldlidedp...sfDvvvafnvLhhl.......dpedpr ++ +++ + +d +++++ +f vv+ ++L ++ +++++ + ++++ mKIAA0859 106 NGsRRpHMSFLKMDMTQLEFpdaTFQVVLDKGTLDAVltdeeevTLRQVD 155 avLrnlrrlLkPGGvl<-* ++L+++ r+L GG+ mKIAA0859 156 RMLAEVGRVLQVGGRY 171 Methyltransf_11: domain 1 of 2, from 68 to 173: score 40.9, E = 2.9e-08 *->LDvGcGtGllaraLarrvgpgarvtGvDlspemlalArerapeagle L +GcG+ l+++L + + +++ +D+s+ +++ +er+ + + mKIAA0859 68 LVIGCGNSELSEQLYDV--GYQDIVNIDISEVVIKQMKERNGSRRPH 112 n.fvvgDaedLPfpDesFDlVvssevlhhl........aedperalrEia +f+++D+++L fpD++F +V+ ++l + +++++ + ++r l+E+ mKIAA0859 113 MsFLKMDMTQLEFPDATFQVVLDKGTLDAVltdeeevtLRQVDRMLAEVG 162 RVLKPGGklvi<-* RVL GG+ ++ mKIAA0859 163 RVLQVGGRYLC 173 TPMT: domain 1 of 1, from 27 to 227: score -65.4, E = 0.016 *->vdedfWlqrW.segqigFHqeevnplLvrhldaFlalpaglRvLVPL +d W++ ++++g+++F + L l + ++ ++vLV + mKIAA0859 27 GSADYWEKFFqQRGKTAFEWYGTYLELCEVLHK--YIKPKEKVLVIG 71 CGKslDlvWLAeqGhfV.....vGvEiSelAvekFFaEanlsYssPkAGi CG s+ L+eq ++V+ ++ v ++iSe +++ + +++ P+ mKIAA0859 72 CGNSE----LSEQLYDVgyqdiVNIDISEVVIKQMKERNGS--RRPH--- 112 telsffkeFkyraggIellCGDfFtLpaeelGkfdliYDRAALvAl.... sf k D L + f+ + D + L A+ +++ mKIAA0859 113 --MSFLKM-------------DMTQLEFPDA-TFQVVLDKGTLDAVltde 146 .ppemRp..rYakqlyeLLppggrLAgLLiTLdYpqaeheGGPPFsVpda ++ +R+ +r ++ + ++L ggr +L i+L + + +V + mKIAA0859 147 eEVTLRQvdRMLAEVGRVLQVGGR--YLCISLAQAHILKK-----AVGHF 189 EleaLfgggfkvaelerdeDaLepeprfkaaGvsalkEkvyvlkrk<-* e+ ++ + va++ + ++ ep rf l + v ++ mKIAA0859 190 SREGWMVRAHQVASSQDRVSEAEP--RFS------LPVFAFVMTKF 227 Methyltransf_12: domain 2 of 2, from 514 to 625: score 7.7, E = 0.56 *->LdiGcGtGrllaalleallnpgaeytgvDiSp.aleiaaaaerladl L +G G G+l ++ ++ +p +++ +v+i+p++le +a + ++ mKIAA0859 514 LVVGLGGGSLPLFVHDH--FPKSRIDAVEIDPtMLE--VATQWFGFS 556 gl.va.rvrldvldlidedp.....sfDvvv........afnvLhhldpe + + + + +d ld i+ + ++ ++++Dv+ + +++++ + + ++ mKIAA0859 557 QSdRMkVHIADGLDYITSLAgeappHYDVIMfdvdskdpTLGMSCPPPAF 606 dpravLrnlrrlLkPGGvl<-* + +L++++ L +Gv+ mKIAA0859 607 VDQVFLQKVKSILCHDGVF 625 Methyltransf_11: domain 2 of 2, from 514 to 627: score 5.1, E = 0.21 *->LDvGcGtGllaraLarrvgpgarvtGvDlspemlalArerapeagle L vG G+G l ++ ++ +p++r+ +v+++p ml++A + ++ + mKIAA0859 514 LVVGLGGGSLPLFVHDH-FPKSRIDAVEIDPTMLEVATQWFGFSQSD 559 n..fvvgDaedL..Pfp.De..sFDlV.........vssevl...hhlae + +++ +D d + +++++++ +D++ + ++++++ ++ +++ ++ mKIAA0859 560 RmkVHIADGLDYitSLAgEAppHYDVImfdvdskdpTLGMSCpppAFV-- 607 dperalrEiaRVLKPGGklvi<-* + +l+ ++ +L +G++++ mKIAA0859 608 -DQVFLQKVKSILCHDGVFIL 627 Spermine_synth: domain 1 of 1, from 430 to 673: score -108.0, E = 0.88 *->iwfteildqfiyLvldseaiidffglwpglavsykVekvLyeeksey i+++ ++ + + l+++ + k k++ + + mKIAA0859 430 IFLSNRNV----------VQSEARLLKDTSHRAQKKRKKDRKKQRPA 466 QdieifesPIGRDEWLFAktfGkvLvtrqGerLaLyLDGvvQltErDEfi ++ e f ++ + +D ++E mKIAA0859 467 DTSEDFPP----------APGQS-------------IDKSYLCCEHH--- 490 YhEmiaHvpllshpRQDNTNpkkVLIIGGGDVKRTVTGRDINGGWVEEVT + m+a+++ll p p L++G G mKIAA0859 491 -KAMVAGLALLRNPELLLETPLTLLVVGLGG------------------- 520 VEGgvLREvlKHpsVNLVQEAYLKTGKEeitlVeIDekVIelskkyLpkl G + ++ H+ + K +i+ VeID+ + e++ + ++ mKIAA0859 521 --GSL--PLFVHDHF----------PKSRIDAVEIDPTMLEVATQWFGFS 556 aagvqqpLSfdDpRvkvvigDGfkflkdyene.hrkFDvII..vDstDvP + R kv+i DG +++ ++ e + +DvI+ +vDs D P mKIAA0859 557 QSD----------RMKVHIADGLDYITSLAGEaPPHYDVIMfdVDSKD-P 595 v....GpaearDTsLFskeFyellkraLkeDGvfvtQatespwlhleliq + ++p +a + + F + +k L DGvf++ + l mKIAA0859 596 TlgmsCPPPA----FVDQVFLQKVKSILCHDGVFILNL---VCRDVRLKD 638 nilrnlkkvfppvvmpyvvtiPTYpsggwgfavaskkislpevdlkn<-* ++l+ lk +fp +++ + + + ++ + ++++ mKIAA0859 639 SVLAGLKAAFP------LLYVRRIEGEVNEILFCQLH------PEQK 673 //