hmmpfam - search a single seq against HMM database
HMMER 2.1.1 (Dec 1998)
Copyright (C) 1992-1998 Washington University School of Medicine
HMMER is freely distributed under the GNU General Public License (GPL).
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HMM file:                 /data11/genetics/InterProScan/iprscan/data/smart.HMMs
Sequence file:            /cdna4/rodent/full/goal/mfj/mfj18276/w3open/interpro/cnk_1/seq.in
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Query:  mKIAA0846  ( 693 res)   mfj18276

Scores for sequence family classification (score includes all domains):
Model    Description                                    Score    E-value  N 
-------- -----------                                    -----    ------- ---
RasGEF   Guanine nucleotide exchange factor for Ras-l   360.9   7.9e-104   1
C1       Protein kinase C conserved region 1 (C1) dom    71.3    1.2e-16   1
RasGEFN  Guanine nucleotide exchange factor for Ras-l    55.1    8.9e-12   1
EFh      EF-hand, calcium binding motif                  30.8    0.00019   2

Parsed for domains:
Model    Domain  seq-f seq-t    hmm-f hmm-t      score  E-value
-------- ------- ----- -----    ----- -----      -----  -------
RasGEFN    1/1       4   127 ..     1   172 []    55.1  8.9e-12
RasGEF     1/1     150   386 ..     1   261 []   360.9 7.9e-104
EFh        1/2     426   454 ..     1    29 []    20.2     0.29
EFh        2/2     455   483 ..     1    29 []    10.8      7.2
C1         1/1     497   546 ..     1    61 []    71.3  1.2e-16

Alignments of top-scoring domains:
RasGEFN: domain 1 of 1, from 4 to 127: score 55.1, E = 8.9e-12
                   *->ckggliKgGtlekLiehLteardk.gkvdlkaDptfv.etFLlTYRs
                       + gl K++tl+ L+  ++e +d++g    + ++++++++ Ll++R+
   mKIAA0846     4    GSNGLGKAATLDELLSTCIEMFDDnG----DLNDSYLpRIVLLMHRW 46   

                   FittqeLlqkLldrYnaippeivsrSlelkateaseglsfedysknaipv
                   + +++eL +kLl  Y+ ++ e                             
   mKIAA0846    47 YLSSTELAGKLLCMYRNASGE----------------------------- 67   

                   gfaetdiivkekvnprriqnrVlnilrlWvenywedFeedpklnlfLeel
                             ++ ++   ++++++++r+W+ +++ +F +d+ l+++ ee 
   mKIAA0846    68 ----------SCDEF---RLKICYFMRYWILKFPAEFNLDLGLIRMTEE- 103  

                   flelvedkkdkgpglekslanilerls<-*
                   f e++ +    g +++ sl +i    s   
   mKIAA0846   104 FREVASQL---GHEKHISLMDISSVPS    127  

RasGEF: domain 1 of 1, from 150 to 386: score 360.9, E = 7.9e-104
                   *->lllldpeelAeQLTlldfelFrkIepsEllgsvwgkrskkspsplap
                      +++l+p elAe+LT+l++++Fr+I++++++++v++++ +++p     
   mKIAA0846   150    FDHLEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNP----- 191  

                   qnleafierfNevsnwVateIlkqttlkpkkRaevlskFIkVAkhcreLn
                    +le++i++fN +s wV+ ++l++++  +++Raev++kFI+VA+++++L+
   mKIAA0846   192 -TLERSIALFNGISKWVQLMVLSKPS--AQQRAEVITKFINVAQKLLQLK 238  

                   NFnSlmAIvsaLssspIsRLkkTWeklsskykklfeeLeelldpserNfk
                   NFn+lmA+v++Ls+s+IsRLk T+++lss+ +k++ e++el++++ +N++
   mKIAA0846   239 NFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSSN-GNYC 287  

                   nYReaLkscnkspnvqppcvPflGvyLkDLtfidegnpdflengtkglvN
                   nYR+a++ c       ++++P+lGv+LkDL++++  +pd+ e+   ++vN
   mKIAA0846   288 NYRKAFADCD------GFKIPILGVHLKDLIAVHVIFPDWMEE---NKVN 328  

                   FeKrrkiakilreirqlqsacqpynlkpnrndiqellrasrplevlpeee
                     K+++++ +l+e+  lq+  ++++l+pn +d+++ll+ s  l+ +++e+
   mKIAA0846   329 VVKMHQLSVTLSELVSLQN--ASHHLEPN-MDLINLLTLS--LDLYHTED 373  

                   delyelSlriEPrv<-*
                    ++y+lSl +EPr+   
   mKIAA0846   374 -DIYKLSLVLEPRN    386  

EFh: domain 1 of 2, from 426 to 454: score 20.2, E = 0.29
                   *->elkeaFrefDkDgdGkIdfeEfkallksl<-*
                       ++ +Fr +D D+dG+I+ e+f  + +++   
   mKIAA0846   426    LVESVFRNYDHDHDGYISQEDFESIAANF    454  

EFh: domain 2 of 2, from 455 to 483: score 10.8, E = 7.2
                   *->elkeaFrefDkDgdGkIdfeEfkallksl<-*
                       + + F ++DkD dG I+++E++a + +    
   mKIAA0846   455    PFLDSFCVLDKDQDGLISKDEMMAYFLRA    483  

C1: domain 1 of 1, from 497 to 546: score 71.3, E = 1.2e-16
                   *->Hkfvfrtf.kptfCdvCrksiwgsfkqaaksqglrCseCkvkcHkkC
                      H+f++ ++ kptfC++C  ++wg+ kq     g++C +C+ +cHk+C
   mKIAA0846   497    HNFQEMNYlKPTFCEHCAGFLWGIIKQ-----GYKCKDCGANCHKQC 538  

                   aekvpaqshksglsC<-*
                   ++ + +       +C   
   mKIAA0846   539 KDLLVL-------AC    546  

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