hmmpfam - search a single seq against HMM database HMMER 2.1.1 (Dec 1998) Copyright (C) 1992-1998 Washington University School of Medicine HMMER is freely distributed under the GNU General Public License (GPL). - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - HMM file: /data11/genetics/InterProScan/iprscan/data/Pfam Sequence file: /cdna4/rodent/full/goal/mbg/mbg03869/w3open/interpro/cnk_1/seq.in - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - - Query: mKIAA0828 ( 478 res) mbg03869 Scores for sequence family classification (score includes all domains): Model Description Score E-value N -------- ----------- ----- ------- --- AdoHcyase S-adenosyl-L-homocysteine hydrolase 584.7 5.6e-172 1 AdoHcyase_NAD S-adenosyl-L-homocysteine hydrolase, NA 365.6 5.2e-106 1 TrkA_N TrkA-N domain -7.6 0.27 1 Shikimate_DH Shikimate / quinate 5-dehydrogenase -17.3 0.095 1 ADH_zinc_N Zinc-binding dehydrogenase -18.0 0.89 1 AlaDh_PNT_C Alanine dehydrogenase/PNT, C-terminal d -46.2 0.023 1 2-Hacid_dh_C D-isomer specific 2-hydroxyacid dehydro -85.5 0.15 1 Parsed for domains: Model Domain seq-f seq-t hmm-f hmm-t score E-value -------- ------- ----- ----- ----- ----- ----- ------- AlaDh_PNT_C 1/1 246 356 .. 1 184 [] -46.2 0.023 Shikimate_DH 1/1 245 362 .. 1 163 [] -17.3 0.095 2-Hacid_dh_C 1/1 238 370 .. 1 189 [] -85.5 0.15 TrkA_N 1/1 262 377 .. 1 121 [] -7.6 0.27 ADH_zinc_N 1/1 258 384 .. 1 150 [] -18.0 0.89 AdoHcyase_NAD 1/1 237 398 .. 1 163 [] 365.6 5.2e-106 AdoHcyase 1/1 51 477 .. 1 309 [] 584.7 5.6e-172 Alignments of top-scoring domains: AlaDh_PNT_C: domain 1 of 1, from 246 to 356: score -46.2, E = 0.023 *->lekygggfgmLlggaggVpPAkVvViGgGVaGlqAaatAkgLGAvVt l ++ m+ gg VvV G G +G + +a+ k +G +V+ mKIAA0828 246 LDGLKRTTDMMFGG------KQVVVCGYGEVGKGCCAALKAMGSIVY 286 ilDvrparleqleslfagfvetdrvlsdeekedaeggGYAkemseeflas ++++ p + +l+ ++ gf + mKIAA0828 287 VTEIDP--ICALQACMDGFRLV---------------------------- 306 naeliaeavkeaDlVIgtvLiPGakAPkLVtremvksMkPGSViVDvAid + e ++++D+VI+ + +Vtre++++Mk +S iV + mKIAA0828 307 ---KLNEVIRQVDIVITCTGN-----KNVVTREHLDRMK-NSCIV---CN 344 qGdnGnvEttrptTtiHsdptyvvdGVvhygvaNlPg<-* G + +T + + mKIAA0828 345 MG--------HSNT-----------------EIDVAS 356 Shikimate_DH: domain 1 of 1, from 245 to 362: score -17.3, E = 0.095 *->gavSissaavdeLAkkifgdlk.gkkvLviGAGgmarlvakhLlskG ++ ++++ ++gk+v+v G+G+ +++++ +L++ G mKIAA0828 245 ILDGLKRTTDM---------MFgGKQVVVCGYGEVGKGCCAALKAMG 282 vkkitiaNRTlekAkeLAeeftnggveiealpldeleiellaeaDivisa +++ +++ ++ + l +l+ e++ ++Divi++ mKIAA0828 283 SI-VYVT-----EIDPICALQ---AC-MDGFRLVKLN-EVIRQVDIVITC 321 TsaplppekdespiltkelveralkakrRkrgPlrlfvDiAVPRDiepeV T+ + ++t+e++ r k+ + +++ + mKIAA0828 322 TGNK-N-------VVTREHLDRM---KN----SC-IVCNM---------G 346 geLegvyvYnvddlkli<-* + + + v + ++++ mKIAA0828 347 HSNTEIDVAS-LRTPEL 362 2-Hacid_dh_C: domain 1 of 1, from 238 to 370: score -85.5, E = 0.15 *->laLlLalaRripeyadrqvraGkWrsglvgvesdygdflgreLsGkT L+++R + +d r+ + ++g Gk mKIAA0828 238 ----LYCCRESI--LDGLKRT---TDMMFG--------------GKQ 261 vGIiGlGrIGravArrakaFGmkViay..drypspeeaeelgveetyryv v + G+G +G+ +ka+G V++++ d+ a + +r v mKIAA0828 262 VVVCGYGEVGKGCCAALKAMGSIVYVTeiDPI----CALQACMD-GFRLV 306 sLdeLLaesDvvslhlPLTpeTrhlinaerlakMKpgAiLINtARGglVD L+e++++ D+v+ ++ +++ + +e l +MK++ i+ N++ mKIAA0828 307 KLNEVIRQVDIVITCTG----NKNVVTREHLDRMKNSCIVCNMGHSNTE- 351 EdALieALksGkIaGAgLDVfepEPlpfkadhPLllalpNVilT<-* +DV l + l+ ++V mKIAA0828 352 -----------------IDVA---SLR--TPE---LTWERVRSQ 370 TrkA_N: domain 1 of 1, from 262 to 377: score -7.6, E = 0.27 *->iiiiGlGrvGrslaeeLse....VvvIDkdeerveelreegpdtlyk ++++G+G vG+ + +L++ ++ V v ++d+ + +l mKIAA0828 262 VVVCGYGEVGKGCCAALKAmgsiVYVTEIDP--------IC--AL-- 296 lvvvGDatdeevLeeAgiedAdaviaatgdDieaNilivllakelnpdgv + D+ + L e i d+vi +tg+ N+ + +e+ ++ mKIAA0828 297 -QACMDGFRLVKLNEV-IRQVDIVITCTGNK---NVVT----REHLDR-- 335 kkiiArandpeh......aekLrr.nlG.......ADeVisP<-* k + + h++++ ++ Lr ++l ++ ++++D+Vi P mKIAA0828 336 MKNSCIVCNMGHsnteidVASLRTpELTwervrsqVDHVIWP 377 ADH_zinc_N: domain 1 of 1, from 258 to 384: score -18.0, E = 0.89 *->pGdtVlVhGaGGGvGlaAvqlAkalGAkarViavdgseeklelAkel G+ V+V G G vG ++++ka+G + V+++++++ + +A mKIAA0828 258 GGKQVVVCGYG-EVGKGCCAALKAMG--SIVYVTEIDPICALQACMD 301 GAdhvinsreedsgamKgqrdeaedvverirelTgGGvDvvidcvGa.pa G v ++ + vD+vi c+G++++ mKIAA0828 302 GFRLVKLN--------------------EVIRQ----VDIVITCTGNkNV 327 tleqalellrpgGrvvvvGl..vpfplrdlllkeltilGslvgg.eefee ++ l+ ++ v+ +G +++++++ l elt + ++ + mKIAA0828 328 VTREHLDRMKNSCIVCNMGHsnTEIDVASLRTPELTWERVRSQVdHVIWP 377 alellas<-* + ++++ mKIAA0828 378 DGKRIVL 384 AdoHcyase_NAD: domain 1 of 1, from 237 to 398: score 365.6, E = 5.2e-106 *->NlYGcReSliDGikRaTDvmiaGKvavvcGYGDVGKGcAasLkgqGA NlY+cReS++DG+kR+TD+m++GK++vvcGYG+VGKGc+a+Lk++G+ mKIAA0828 237 NLYCCRESILDGLKRTTDMMFGGKQVVVCGYGEVGKGCCAALKAMGS 283 rVivTEiDPIcALQAaMeGfeVvtleevvkkadifVTtTGnkDiitlehl +V+vTEiDPIcALQA+M+Gf+ v+l+ev++++di++T+TGnk+++t+ehl mKIAA0828 284 IVYVTEIDPICALQACMDGFRLVKLNEVIRQVDIVITCTGNKNVVTREHL 333 ekmkddaIVcNiGHfdnEIdvagLeanpaikkeniKPqvDrytlpdGkki ++mk+++IVcN+GH+++EIdva+L+++ ++++e++++qvD++++pdGk+i mKIAA0828 334 DRMKNSCIVCNMGHSNTEIDVASLRTP-ELTWERVRSQVDHVIWPDGKRI 382 IlLaeGRLlNLGcAtg<-* +lLaeGRLlNL+c+t+ mKIAA0828 383 VLLAEGRLLNLSCSTV 398 AdoHcyase: domain 1 of 1, from 51 to 477: score 584.7, E = 5.6e-172 RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx *->adYkVKDIsLAaFGRkEielAEnEMPGLMalReeYGpsqPLKGArIa d++VK I++A+FGR+Eie+AE EMP LMalR+++ ++PL GA+I+ mKIAA0828 51 SDFCVKNIKQAEFGRREIEIAEQEMPALMALRKRAQGEKPLAGAKIV 97 RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx GCLHMTvQTAVLIETLtALGAeVRWaSCNIFSTQDhAAAAIAkaGvPVFA GC+H T+QTAVL ETL ALGA+ RWa+CNI+ST + +AAA+A++G PVFA mKIAA0828 98 GCTHITAQTAVLMETLGALGAQCRWAACNIYSTLNEVAAALAESGFPVFA 147 RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx WKGETlEEYwWCieraltfkDGqgpnmILDDGGDATlLihkGvevEkeye WKGE + +wWCi+r + +G++pnmILDDGGD+T+ i k mKIAA0828 148 WKGESEDDFWWCIDRCV-NVEGWQPNMILDDGGDLTHWIYK--------- 187 RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx ekealPdpekekNeEercvLtllKkslkkdPkKypqllaaIrGvSEETTT Kyp+++++I+G++EE++T mKIAA0828 188 --------------------------------KYPNMFKKIKGIVEESVT 205 RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx GVhRLYkmskkGkLlfPAINVNDSVTKSKFD................... GVhRLY++sk GkL +PA NVNDSVTK+KFD+ +++ ++ +++++ mKIAA0828 206 GVHRLYQLSKAGKLCVPAMNVNDSVTKQKFDnlyccresildglkrttdm 255 RF .................................................. +++ + ++ +++ + ++ ++ ++ ++ + mKIAA0828 256 mfggkqvvvcgygevgkgccaalkamgsivyvteidpicalqacmdgfrl 305 RF .................................................. + ++ + + + +++++ ++++ ++ +++ + ++++++ + mKIAA0828 306 vklnevirqvdivitctgnknvvtrehldrmknscivcnmghsnteidva 355 RF xxxxxxxx ..........................................HPSFVMSn + ++++ + ++ ++ ++ +++++ +++ + + ++ P FV S mKIAA0828 356 slrtpeltwervrsqvdhviwpdgkrivllaegrllnlscstVPTFVLSI 405 RF xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx SFTNQvLAQiELWtkrdtgkYevgVYvLPKhLDEkVArLHLgkLgvkLTk T+Q+LA+iEL++++ g+Y+ +VY+LPK++DE+VA+LHL +++++LT+ mKIAA0828 406 TATTQALALIELYNAP-EGRYKQDVYLLPKKMDEYVASLHLPTFDAHLTE 454 RF xxxxxxxxxxxxxxxxxxxxxxx LtdkQAeYlGvpveGPFKsdhYR<-* Ltd+QA+YlG++++GPFK+++YR mKIAA0828 455 LTDEQAKYLGLNKNGPFKPNYYR 477 //